Results 161 to 170 of about 1,104,726 (307)

Profiling of HCAR1 signalling reveals Gαi/o and Gαs activation without β‐arrestin recruitment and the discovery of an allosteric agonist

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Lactate, historically viewed as a metabolic by‐product, has emerged as a signalling molecule via the G protein–coupled receptor Hydroxycarboxylic Acid Receptor 1 (HCAR1). The receptor is primarily expressed in adipocytes but also found in various other tissues.
Simon Lind   +6 more
wiley   +1 more source

Homo sapiens, industrialisation and the environmental mismatch hypothesis

open access: yesBiological Reviews, EarlyView.
ABSTRACT For the vast majority of the evolutionary history of Homo sapiens, a range of natural environments defined the parameters within which selection shaped human biology. Although human‐induced alterations to the terrestrial biosphere have been evident for over 10,000 years, the pace and scale of change has accelerated dramatically since the onset
Daniel P. Longman, Colin N. Shaw
wiley   +1 more source

Occurrence and evolution of cannibal behaviour in extant snakes

open access: yesBiological Reviews, EarlyView.
ABSTRACT Extant snakes (Serpentes) are a highly diverse group of squamate reptiles, which have independently evolved key morphological adaptations to consume a large variety of vertebrate and invertebrate prey. While these predator–prey interactions have been widely addressed by several studies, little is known regarding the occurrence of cannibal ...
Bruna B. Falcão   +2 more
wiley   +1 more source

Vulnerability of marine megafauna to global at‐sea anthropogenic threats

open access: yesConservation Biology, EarlyView.
Abstract Marine megafauna species are affected by a wide range of anthropogenic threats. To evaluate the risk of such threats, species’ vulnerability to each threat must first be determined. We build on the existing threats classification scheme and ranking system of the International Union for Conservation of Nature (IUCN) Red List of Threatened ...
Michelle VanCompernolle   +309 more
wiley   +1 more source

Between Exclusion and Legitimacy: Identity Negotiation and Ethical Dilemmas of Chinese Lesbians in the Assisted Reproduction System

open access: yesDeveloping World Bioethics, EarlyView.
ABSTRACT In China's current assisted reproduction system, marriage and sexual orientation serve as key entry barriers, leaving lesbians facing institutional exclusion under the dual identities of “unmarried” and “non‐heterosexual.” The marriage system, heterosexual norms, and technical regulations jointly construct the institutional structure that ...
Yuan Liu
wiley   +1 more source

Solving the trophic puzzle: Host–parasite associations in Neotropical fig wasps associated with fig trees of section Americanae

open access: yesEcological Entomology, EarlyView.
We determined the trophic associations among fig wasp species associated with Ficus citrifolia by integrating gall morphology, the temporal sequence of wasp colonization, and oviposition behaviour. Dissection of galls produced by four gall‐inducing species at a late developmental phase enabled direct identification of occupants and inference of host ...
Leví Oliveira Barros   +2 more
wiley   +1 more source

Environmental stress influences reproductive success in male spider mites

open access: yesEcological Entomology, EarlyView.
This experiment explores how male juvenile food stress impacts reproductive traits in the haplodiploid spider mite Tetranychus urticae. Males exposed to juvenile food stress had lower reproductive success and females mated to these males also suffered reduced fitness as they were not able to produce optimal offspring sex ratios. The negative effects of
Elsa Noël   +4 more
wiley   +1 more source

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