Results 41 to 50 of about 24,432 (235)

Switchable genome editing via genetic code expansion [PDF]

, 2018
Multiple applications of genome editing by CRISPR-Cas9 necessitate stringent regulation and Cas9 variants have accordingly been generated whose activity responds to small ligands, temperature or light.
Asami, Maki, Luk, Louis Y. P., Patel, Sanjay G., Perry, Anthony C. F., Suzuki, Toru, Tsai, Yu-Hsuan   +5 more
core   +2 more sources

Pregnancy outcomes in women with systemic sclerosis before and/or after diagnosis, and by parity ‐ A Swedish population‐based cohort study

Arthritis &Rheumatology, Accepted Article.
Objective To assess risks of adverse pregnancy outcomes (APO) in a contemporary cohort of women with systemic sclerosis (SSc) in relation to the timing of SSc diagnosis and by parity. Methods From the nationwide Swedish Medical Birth Register, we assembled pregnancies with births in women with SSc and in comparator women from the general population ...
Weng Ian Che, Luigi Annicchiarico, Laura Andreoli, Olof Stephansson, Marie Holmqvist, Karin Hellgren   +5 more
wiley   +1 more source

The Type of Follicle‐Stimulating Hormone Medication Given for In Vitro Fertilization Impacts Oocyte Retrieval: A Systematic Review and Meta‐Analysis

Clinical Pharmacology &Therapeutics, EarlyView.
Understanding the variability in ovarian response following administration of follicle‐stimulating hormone medications in women undergoing in vitro fertilization may help inform prescribing decisions. A systematic review was conducted to compare the number of retrieved oocytes and fertility outcomes following the administration of different follicle ...
Toni J.F. Michael, Ranita Kirubakaran, Tanay Parab, Rui Wang, Mark Grosser, Beverley J. Vollenhoven, Vinayak Smith, Sophie L. Stocker, on behalf of the LIFE Consortium, Beverley Vollenhoven, Franca Agresta, Mian Bi, Emanuel Birru, David Coman, Nicholas Devereaux, David Gardner, Mark Grosser, Grant Hatamosa, Fabrizzio Horta, Hua Lin, David Listijono, Gavin Sacks, Vinayak Smith, Kate Stern, Sophie Stocker, Steven Tipper, Deon Venter, Rui Wang   +27 more
wiley   +1 more source

Sperm retrieval by microdissection testicular sperm extraction and intracytoplasmic sperm injection outcomes in nonobstructive azoospermic patients with Klinefelter syndrome

Andrologia, 2018
Klinefelter syndrome is the most frequent chromosomal abnormality in patients with nonobstructive azoospermia. The development of advanced assisted reproductive techniques, such as testicular sperm extraction and intracytoplasmic sperm injection, has ...
Cevahir Özer, P. Aytac, M. Goren, S. Toksoz, Umit Gul, T. Turunç   +5 more
semanticscholar   +1 more source

TUBA1A‐related tubulinopathy associated with the infantile epileptic spasms syndrome and atypical absence seizures

Epileptic Disorders, EarlyView.
Abstract Patients with TUBA1A pathogenic variants may present with complex brain malformation, intellectual disability, and epilepsy. The epilepsy phenotype is varied, ranging from mild to severe, with epileptic spasms and focal seizures being the most common seizure types.
Andy Cheuk‐Him Ng, Morris H. Scantlebury   +1 more
wiley   +1 more source

Phenotypic continuum and poor intracytoplasmic sperm injection intracytoplasmic sperm injection prognosis in patients harboring HENMT1 variants

Andrology
Small RNAs interacting with PIWI (piRNAs) play a crucial role in regulating transposable elements and translation during spermatogenesis and are essential in male germ cell development.
Zeina Wehbe, A. Barbotin, Angèle Boursier, Caroline Cazin, J. Hograindleur, M. Bidart, Emeline Fontaine, Pauline Plouvier, Florence Puch, V. Satre, C. Arnoult, Selima Fourati Ben Mustapha, R. Zouari, Nicolas Thierry-Mieg, P. Ray, Z. Kherraf, C. Coutton, G. Martinez   +17 more
semanticscholar   +1 more source

The association between levonorgestrel intrauterine devices and female fertility compared to other contraceptive methods: A historical cohort study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective This study aimed to investigate whether the use of levonorgestrel intrauterine devices (LNG‐IUD) is associated with an increased need for medically assisted reproductive (MAR) treatment compared to other contraceptive methods. Methods This register‐based historical cohort study included 733 875 Danish women aged 18–42 years between ...
Mette Peters Michaelsen, Laura Cæcilie Nielsen, Michelle Poulsen, Regitze Gyldenholm Skals, Søren Lundbye‐Christensen, Ulrik Schiøler Kesmodel   +5 more
wiley   +1 more source

Cancer and fertility management: FIGO best practice advice

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Cancer diagnoses in patients of reproductive age require balancing urgent oncological treatment with the need to preserve fertility. This FIGO Best Practice Advice outlines key considerations for fertility management in this population given the rising cancer incidence among young women and the reproductive risks posed by cancer treatments ...
Nikhil Purandare, Francisco Ruiloba, Long Nguyen‐Hoang, Sarikapan Wilailak, Nozomu Yanaihara, Jacqueline P. W. Chung, Jaideep Malhotra, Edgar Mocanu, Frédéric Amant, Orla McNally, Inge Peters, Katie Flynn, Aya El Helali, Cynthia Maxwell, Sumaiya Adam, Lina Bergman, Surabhi Nanda, Valerie Tiempo Guinto, Fionnuala M. McAuliffe, Catherine Nelson‐Piercy, Melanie Nana, Graeme Smith, Jonathan Berek, Sharleen O'Reilly, Pat O'Brien, Bo Jacobsson, Liona C. Poon, on behalf of the FIGO Committee on the Impact of Pregnancy on Long‐term Health and the FIGO Division of Maternal and Newborn Health and in collaboration with the FIGO Committee on Women's Cancer and the FIGO Committee on Reproductive Medicine, Endocrinology and Infertility   +28 more
wiley   +1 more source

FIGO good practice recommendations on preconception care: A strategy to prevent preterm birth

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Preterm birth (PTB) remains one of the leading causes of neonatal mortality and long‐term morbidity worldwide, with minimal progress being made in reducing its incidence, particularly in low‐resource settings. Preconception care is recognized as an effective strategy for PTB prevention; however, the fact that more than half of pregnancies ...
Leticia Irma Ojeda, Catalina M. Valencia, Natalia Cardozo Buitrago, Dilly Anumba, Wondimu Gudu, Ana Bianchi, Bo Jacobsson, on behalf of the FIGO Committee for Preterm Birth, Catalina M. Valencia González, Dilly Anumba, Wondimu Gudu, Bo Jacobsson, Nancy Sierra Lozada, Leticia Ojeda, Madhuri Patel, Andrew Shennan, Rodrigo Rigoni, Priya Soma‐Pillay, Sherri Ann Suplido, Ana Daneva, Sikolia Wanyonyi, Haim Abenhaim   +21 more
wiley   +1 more source

Functional parameters of spermatozoa obtained by a new selection device. [PDF]

FEBS Open Bio
This study compares density gradient centrifugation and the LensHooke CA0™ device for sperm separation. DGC requires multiple steps, specialized equipment, and technical expertise. In contrast, the CA0 device offers key practical and methodological advantages, resulting in a faster, simpler, and more affordable sperm selection method.
Chávez JC, Torres P, Carrasquel-Martínez G, Figueroa-Méndez MG, Flores D, Villar L, Maldonado I, Trevino MB, Treviño C.   +8 more
europepmc   +2 more sources