Results 101 to 110 of about 1,206,650 (354)

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

open access: yesFEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp   +5 more
wiley   +1 more source

On Limits of Dense Packing of Equal Spheres in a Cube [PDF]

open access: yes, 2015
We examine packing of $n$ congruent spheres in a cube when $n$ is close but less than the number of spheres in a regular cubic close-packed (ccp) arrangement of $\lceil p^{3}/2\rceil$ spheres.
Tatarevic, Milos
core  

Development of a global thermal detection index to prioritize primate research with thermal drones

open access: yesScientific Reports
Thermal Infrared (TIR) drones are emerging as effective tools for wildlife ecology monitoring and are increasingly employed in primate surveys. However, systematic methods for assessing primate detectability are lacking.
Eva Gazagne   +4 more
doaj   +1 more source

PLURIPOTENT STEM CELLS FROM THE ADULT MOUSE UTRICLE

open access: yesScientific Papers Animal Science and Biotechnologies, 2023
Researchers discovered that cochlear epithelia in mice especially the vestibular one, contains stem cells that have the capacity to differentiate in sensorial auditory hair cell progenitors specific to the organ.
ROXANA DANIELA VINTILĂ   +8 more
doaj  

A Reeb sphere theorem in graph theory [PDF]

open access: yesarXiv, 2019
We prove a Reeb sphere theorem for finite simple graphs. The result bridges two different definitions of spheres in graph theory. We also reformulate Morse conditions in terms of the center manifolds, the level surface graphs {f=f(x)} in the unit sphere S(x).
arxiv  

Optimal Finite Homogeneous sphere approximation [PDF]

open access: yesarXiv, 2020
The two dimensional sphere can't be approximated by finite homogeneous spaces. We describe the optimal approximation and its distance from the sphere.
arxiv  

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

open access: yesFEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro   +2 more
wiley   +1 more source

Theoretical assessment of the disparity in the electrostatic forces between two point charges and two conductive spheres of equal radii

open access: yes, 2016
The Coulomb's formula for the force FC of electrostatic interaction between two point charges is well known. In reality, however, interactions occur not between point charges, but between charged bodies of certain geometric form, size and physical ...
Kolikov, Kiril
core   +2 more sources

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

open access: yesFEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt   +4 more
wiley   +1 more source

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

open access: yesFEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel   +2 more
wiley   +1 more source

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