Results 141 to 150 of about 1,206,650 (354)

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

open access: yesMolecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić   +31 more
wiley   +1 more source

The local-global principle for integral bends in orthoplicial Apollonian sphere packings [PDF]

open access: yesarXiv, 2014
We introduce an orthoplicial Apollonian sphere packing, which is a sphere packing obtained by successively inverting a configuration of 8 spheres with 4-orthplicial tangency graph. We will show that there are such packings in which the bends of all constituent spheres are integral, and establish the asymptotic local-global principle for the set of ...
arxiv  

Detection rate for ESR1 mutations is higher in circulating‐tumor‐cell‐derived genomic DNA than in paired plasma cell‐free DNA samples as revealed by ddPCR

open access: yesMolecular Oncology, EarlyView.
Analysis of ESR1 mutations in plasma cell‐free DNA (cfDNA) is highly important for the selection of treatment in patients with breast cancer. Using multiplex‐ddPCR and identical blood draws, we investigated whether circulating tumor cells (CTCs) and cfDNA provide similar or complementary information for ESR1 mutations.
Stavroula Smilkou   +11 more
wiley   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

open access: yesMolecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin   +14 more
wiley   +1 more source

Set of the factors influencing development of innovative economy

open access: yesПутеводитель предпринимателя, 2020
In article the role and a place of «the human capital» in aggregate economic resources is defined and analyzed.

doaj  

New constructions of biharmonic polynomial maps between spheres [PDF]

open access: yesarXiv
In this paper, we study diagonal maps between spheres given by two homogeneous polynomial maps between spheres, defined on the same domain sphere. First we find their bitension field, then we give a method for generating proper biharmonic maps between spheres, relying on harmonic homogeneous polynomial maps of different degrees. Further, we establish a
arxiv  

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