Results 161 to 170 of about 316,592 (249)
TREX1, a predator for treating MSI‐H tumors?
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya +2 more
wiley +1 more source
Continuous and Scalable Production of Uniform Au Nanocrystals Capped by Citrate Species in Flow Reactors for Lateral Flow Tests. [PDF]
He J, Li KK, Huang Q, Xia Y.
europepmc +1 more source
Terms of professional self-perfection of specialists of social sphere are in resource centerc [PDF]
Наталія Євгенівна Тимошенко
openalex
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Regioselective synthesis of novel spiro-isoxazolines congeners as antimicrobial agents: <i>in vitro</i> and <i>in-silico</i> assessments. [PDF]
Bouzammit R +13 more
europepmc +1 more source
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
A self-assembled two-dimensional hypersonic phononic insulator. [PDF]
Moronta P +6 more
europepmc +1 more source
Business-elite as the Special Subject of the Manipulation in the Political Sphere
Zulfia Sergeeva
openalex +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source

