Results 231 to 240 of about 403,301 (348)

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome

Advanced Science, EarlyView.
Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel, Anna Meurer, Badeel Kh. Q. Zaghla, Bilge Atay, Daniel Steiert, Luca V. Hummel, Konstandina Isaakidis, Chuanbing Zang, Michael Korenkov, Marlon Schielin, Schayan Yousefian, Shima Mecklenbräuker, Marieluise Kirchner, Simon Haas, Antonia Busse, Philipp Mertins, Stefan Müller, Matthias Wirth, Martin G. Klatt, Ulrich Keller   +19 more
wiley   +1 more source

Aptamer-based approaches for sensitive detection and epitope mapping of SARS-CoV-2 spike protein. [PDF]

Mol Ther Nucleic Acids
Poolsup S, Yaghoobi E, Radchanka A, Mulloo N, Uguccioni S, Pezacki JP, Khraibah A, Jawad A, Uppal GK, Gu Y, Lapointe BP, Hüttmann N, Minic Z, Artyushenko PV, Shchugoreva IA, Rogova AV, Tomilin FN, Morozov D, Kichkailo AS, Kolovskaya OS, Berezovski MV.   +20 more
europepmc   +1 more source

Structural analysis of COVID-19 spike protein in recognizing the ACE2 receptor of different mammalian species and its susceptibility to viral infection

, 2021
Tirthankar Koley, Shivani Madaan, Sanghati Roy Chowdhury, Manoj Kumar, Punit Kaur, T.P. Singh, A.S. Ethayathulla   +6 more
openalex   +2 more sources

A Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses

Advanced Science, EarlyView.
Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng, Jing Sun, Chun Lu, Qian Yu, Yiyun He, Bingqing Wu, Deshan Ren, Shuai Ding, Jincun Zhao, Yan Li   +9 more
wiley   +1 more source

Spike protein-induced VSIR-ISX signaling disrupts metabolic homeostasis and promotes COVID-19-related immune dysfunction. [PDF]

Cell Biol Toxicol
Wang LT, Wang SN, Chiou SS, Chai CY, Hsu SH.   +4 more
europepmc   +1 more source

Nanoparticle Adjuvant Design Enhances Germinal Center Responses Targeting Conserved Subdominant Epitopes for Pan‐Coronavirus Vaccine Development

Advanced Science, EarlyView.
Current SARS‐CoV‐2 vaccines generate short‐lived, strain‐specific immunity. A polymeric TLR7 agonist nanoparticle (TLR7‐NP) adjuvant enhances lymph node targeting and promotes early and sustained germinal center responses toward conserved S2 epitopes of the spike protein.
Sijin Huang, Kanella M. Cohen, Liqiang Chen, Xiaowo Kang, Chang Liu, Megan E. Demouth, Wenxia Jiang, Alexander R. Maldeney, Rong Tong, Zunlong Ke, Kartik Chandran, Wei Luo, Qian Yin   +12 more
wiley   +1 more source

Correction: de Melo et al. SARS-CoV-2 Spike Protein and Long COVID-Part 1: Impact of Spike Protein in Pathophysiological Mechanisms of Long COVID Syndrome. <i>Viruses</i> 2025, <i>17</i>, 617. [PDF]

Viruses
de Melo BP, da Silva JAM, Rodrigues MA, Palmeira JDF, Saldanha-Araujo F, Argañaraz GA, Argañaraz ER.   +6 more
europepmc   +1 more source

Adenylyl Cyclase 8 in Dorsal CA1 Neurons Prevents Depressive‐Like Behaviors by Maintaining Neuronal Excitability and Glutamatergic Neurotransmission Through TIP39‐PTH2R Signaling

Advanced Science, EarlyView.
Depression, a prevalent neuropsychiatric disorder with unclear pathogenesis, involves dysfunctional adenylyl cyclase 8 (Adcy8) as a key risk factor. Chronic stress selectively reduces Adcy8 expression in the dorsal CA1 (dCA1) neurons. Depletion of Adcy8 in dCA1 excitatory neurons induces depressive‐like behaviors by impairing neuronal excitability and ...
Zi‐Jie Liu, Jia‐Rui Bi, Zong‐Yan Yu, Meng Tian, Zhi‐Yue Chen, Ran Wei, Miao‐Miao Wang, Hai‐Wei Zha, Yu‐Qing Zhang, Hong‐Jing Wang, Bang‐You Qiang, Shuang‐Shuang Sun, Xiao‐Juan Zhu, Wen‐Bing Chen, Dong Sun   +14 more
wiley   +1 more source

Molecular Insights into the Interaction between CD147 and the SARS-CoV‑2 Spike Protein. [PDF]

ACS Omega
Gonzalez-Serrano MS, Chen LY, Desai H, Ho TH, Heinrich D, Trinh TT, Nguyen TH.   +6 more
europepmc   +1 more source

Spike Frequency Decoding and Autonomous Activation of Ca²⁺–Calmodulin-Dependent Protein Kinase II in Dorsal Root Ganglion Neurons [PDF]

, 2001
Feleke Eshete, R. Douglas Fields
openalex   +1 more source