Results 51 to 60 of about 25,328 (252)

Sustained oscillations, irregular firing and chaotic dynamics in hierarchical modular networks with mixtures of electrophysiological cell types

Frontiers in Computational Neuroscience, 2014
The cerebral cortex exhibits neural activity even in the absence of externalstimuli. This self-sustained activity is characterized by irregular firing ofindividual neurons and population oscillations with a broad frequency range.Questions that arise in ...
Petar eTomov, Rodrigo Felipe De Oliveira Pena, Michael A Zaks, Antonio C Roque   +3 more
doaj   +1 more source

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source

Modeling cortical synaptic effects of anesthesia and their cholinergic reversal.

PLoS Computational Biology, 2022
General anesthetics work through a variety of molecular mechanisms while resulting in the common end point of sedation and loss of consciousness. Generally, the administration of common anesthetics induces reduction in synaptic excitation while promoting
Bolaji P Eniwaye, Victoria Booth, Anthony G Hudetz, Michal Zochowski   +3 more
doaj   +1 more source

Computing with Spiking Neuron Networks [PDF]

, 2012
Abstract Spiking Neuron Networks (SNNs) are often referred to as the 3rd gener- ation of neural networks. Highly inspired from natural computing in the brain and recent advances in neurosciences, they derive their strength and interest from an ac- curate modeling of synaptic interactions between neurons, taking into account the time of spike firing ...
H. Paugam-Moisy, S.M. Bohte (Sander)
openaire   +3 more sources

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

A Neuron Model for FPGA Spiking Neuronal Network Implementation

Advances in Electrical and Computer Engineering, 2011
We propose a neuron model, able to reproduce the basic elements of the neuronal dynamics, optimized for digital implementation of Spiking Neural Networks. Its architecture is structured in two major blocks, a datapath and a control unit.
BONTEANU, G., TIGAERU, L.
doaj   +1 more source

Mapping cortical mesoscopic networks of single spiking cortical or sub-cortical neurons

eLife, 2017
Understanding the basis of brain function requires knowledge of cortical operations over wide-spatial scales, but also within the context of single neurons.
Dongsheng Xiao, Matthieu P Vanni, Catalin C Mitelut, Allen W Chan, Jeffrey M LeDue, Yicheng Xie, Andrew CN Chen, Nicholas V Swindale, Timothy H Murphy   +8 more
doaj   +1 more source

Communication through Resonance in Spiking Neuronal Networks

PLoS Computational Biology, 2014
The cortex processes stimuli through a distributed network of specialized brain areas. This processing requires mechanisms that can route neuronal activity across weakly connected cortical regions. Routing models proposed thus far are either limited to propagation of spiking activity across strongly connected networks or require distinct mechanisms ...
Hahn, Gerald, Bujan, Alejandro F., Frégnac, Yves, Aertsen, Ad, Kumar, Arvind, Brunel, Nicolas   +5 more
openaire   +5 more sources

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian, Tianjia Zhu, Hao Huang, Shavonne L. Massey, Mark P. Fitzgerald, Darshana Parikh, Arastoo Vossough, Ingo Helbig, Nicholas S. Abend   +8 more
wiley   +1 more source

High-Temperature, but Not High-Pressure, Conditions Alter Neuronal Activity

Journal of Pharmacological Sciences, 2009
.: We describe the effect of high pressure and high temperature on neuronal activity. Increased intracranial pressure is generally a pathological sign observed in intracerebral hemorrhage, brain edema, and brain tumor, yet little is known about how the ...
Mika Mizunuma, Naoya Takahashi, Atsushi Usami, Norio Matsuki, Yuji Ikegaya   +4 more
doaj   +1 more source