Results 51 to 60 of about 4,781,385 (251)

Maximum likelihood decoding of neuronal inputs from an interspike interval distribution [PDF]

, 2009
An expression for the probability distribution of the interspike interval of a leaky integrate-and-fire (LIF) model neuron is rigorously derived, based on recent theoretical developments in the theory of stochastic processes.
You, Gongqiang, Feng, Jianfeng, Zhang, Xuejuan, Chen, Tianping   +3 more
core   +1 more source

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source

Co-learning synaptic delays, weights and adaptation in spiking neural networks

Frontiers in Neuroscience
Spiking neural network (SNN) distinguish themselves from artificial neural network (ANN) because of their inherent temporal processing and spike-based computations, enabling a power-efficient implementation in neuromorphic hardware.
Lucas Deckers, Laurens Van Damme, Werner Van Leekwijck, Ing Jyh Tsang, Steven Latré   +4 more
doaj   +1 more source

Sustained oscillations, irregular firing and chaotic dynamics in hierarchical modular networks with mixtures of electrophysiological cell types

Frontiers in Computational Neuroscience, 2014
The cerebral cortex exhibits neural activity even in the absence of externalstimuli. This self-sustained activity is characterized by irregular firing ofindividual neurons and population oscillations with a broad frequency range.Questions that arise in ...
Petar eTomov, Rodrigo Felipe De Oliveira Pena, Michael A Zaks, Antonio C Roque   +3 more
doaj   +1 more source

Goodness-of-fit tests for neural population models: the multivariate time-rescaling theorem [PDF]

, 2010
Poster Presentation from Nineteenth Annual Computational Neuroscience Meeting: CNS*2010 San Antonio, TX, USA. 24-30 July 2010 Statistical models of neural activity are at the core of the field of modern computational neuroscience.
Haslinger Robert, Gerhard, Felipe, Pipa, Gordon, Pipa Gordon, Felipe Gerhard, Gordon Pipa, Haslinger, Robert, Gerhard Felipe, Robert Haslinger   +8 more
core   +2 more sources

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Modeling cortical synaptic effects of anesthesia and their cholinergic reversal.

PLoS Computational Biology, 2022
General anesthetics work through a variety of molecular mechanisms while resulting in the common end point of sedation and loss of consciousness. Generally, the administration of common anesthetics induces reduction in synaptic excitation while promoting
Bolaji P Eniwaye, Victoria Booth, Anthony G Hudetz, Michal Zochowski   +3 more
doaj   +1 more source

Real-time inference in a VLSI spiking neural network [PDF]

, 2012
The ongoing motor output of the brain depends on its remarkable ability to rapidly transform and fuse a variety of sensory streams in real-time.
Matthew Cook, Neftci, Emre O; https://orcid.org/, Corneil, Dane, Dane Corneil, Neftci, Emre, Emre Neftci, Sonnleithner, Daniel, Rodney Douglas, Chicca, Elisabetta; https://orcid.org/, Giacomo Indiveri, Elisabetta Chicca, Indiveri, Giacomo; https://orcid.org/, Indiveri, Giacomo, Chicca, Elisabetta ; https://orcid.org/, Cook, Matthew, Daniel Sonnleithner, Douglas, Rodney   +16 more
core   +1 more source

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian, Tianjia Zhu, Hao Huang, Shavonne L. Massey, Mark P. Fitzgerald, Darshana Parikh, Arastoo Vossough, Ingo Helbig, Nicholas S. Abend   +8 more
wiley   +1 more source

Mapping cortical mesoscopic networks of single spiking cortical or sub-cortical neurons

eLife, 2017
Understanding the basis of brain function requires knowledge of cortical operations over wide-spatial scales, but also within the context of single neurons.
Dongsheng Xiao, Matthieu P Vanni, Catalin C Mitelut, Allen W Chan, Jeffrey M LeDue, Yicheng Xie, Andrew CN Chen, Nicholas V Swindale, Timothy H Murphy   +8 more
doaj   +1 more source