Results 191 to 200 of about 117,222 (310)

How the HTAR will contribute to a value‐based decision‐making for medicinal products across the EU

British Journal of Clinical Pharmacology, EarlyView.
The European Union Health Technology Regulation 2021/2282 (HTAR) introduces joint assessment of health technologies (including medicinal products and medical devices) across EU Member States. It was signed into law in 2021 and came into full force in January 2025.
Roisin Adams, Michal Stanak
wiley   +1 more source

Neural integrator and orchestrator communities shape spontaneous signaling in the human brain. [PDF]

PNAS Nexus
Pini L, Dugo R, Pigato P, Corbetta M.
europepmc   +1 more source

Evaluating the (comparative) safety profile of the novel oral polio vaccine type 2 using individual case safety reports in VigiBase

British Journal of Clinical Pharmacology, EarlyView.
Aim Novel oral polio vaccine type 2 (nOPV2) was used under the WHO emergency use listing for circulating vaccine‐derived polio virus (cVDPV) outbreaks from 2021 to 2023. We assessed nOPV2 adverse events following immunization (AEFIs) and compared its safety profile to other vaccines using VigiBase.
Comfort Kunak Ogar, Malede Mequanent Sisay, Leonardo Roque‐Pereira, Christine Leopold, Patrick C. Souverein, Aukje K. Mantel‐Teeuwisse, Marie L. De Bruin   +6 more
wiley   +1 more source

Cultural practices, wildlife trade dynamics, and climate-migration interactions: an integrated one health approach to reducing zoonotic spillover risks in Africa. [PDF]

Front Vet Sci
Emikpe BO, Kong JD, Nsagha DS, Adesina S, Ayana G, Niyukuri D, Badjo E, Folitse RD, Yakubu AR, Takyi PN, Yeboah S, Ochai SO, Meyir ZY, Dzasi KK.   +13 more
europepmc   +1 more source

Defining a comprehensive set of value assessment criteria for funders of drug repurposing initiatives

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aims to develop a structured list of value assessment criteria for drug repurposing (DR) projects designed to support consistent, evidence‐informed decision‐making by funders. The assessment criteria were developed within the REMEDi4ALL project, a multi‐stakeholder Horizon Europe funded initiative to advance DR and were validated ...
Dalma Hosszú, Kristóf Gyöngyösi, András Perényi, Helene G. van der Meer, Dunja Huijbers, Pan Pantziarka, András Inotai, Donald C. Lo, Rick Thompson, Zoltán Kaló, Marcell Csanádi   +10 more
wiley   +1 more source

Effective methods for increasing levels of political self‐efficacy for girls and disadvantaged students in England

British Educational Research Journal, EarlyView.
Abstract This study addresses the gap in rigorous evaluation of inclusive Citizenship Education methods in reducing gender and socioeconomic inequalities in political self‐efficacy. This article tests the effectiveness of two pedagogical approaches: counter‐narratives and think‐pair‐share.
Bryony Hoskins, Khuyen Dinh, Christian Christrup Kjeldsen   +2 more
wiley   +1 more source

Origins of pandemics: Why ecological disruption is central to global health security and the imperative for proactive prevention. [PDF]

One Health
Mahmood S, Naden P, Thapa S, Gibbs P.
europepmc   +1 more source

Characterization of Immune Responses to RBD‐SD1 Nanoparticle Vaccines Derived From ACE2‐Capable HKU5‐CoV‐2, NeoCoV, and HKU5 Merbecoviruses

Biotechnology and Bioengineering, EarlyView.
SpyCatcher‐mi3 nanoparticles presenting HKU5, NeoCoV, and HKU5‐CoV‐2 RBD‐SD1 induced strong, cross‐reactive IgG responses in immunized mice. The surrogate virus neutralization test demonstrated strong activity in sera from homologous vaccination. ABSTRACT Recent discoveries of merbecoviruses such as HKU5, NeoCoV, and HKU5‐CoV‐2 that use angiotensin ...
Peter J. Halfmann, Jeong Soo Lee, Augustine Duffy, Tong Wang, Bingcheng Huang, James Z. Kurdi, Ajay Inampudi, Natasha Chen, Elizabeth Frimpong, Carmen Rai, Yoshihiro Kawaoka, Ravi S. Kane   +11 more
wiley   +1 more source

Hydrogen Spillover from Pt, Pd, and Au Evaluated with MnO _<i>x</i> Temperature-Programmed Reduction. [PDF]

JACS Au
Hamidizirasefi M, Battiste AM, Pathickal Abraham A, Dimon AP, Chandler BD.   +4 more
europepmc   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source