Results 41 to 50 of about 145,803 (246)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Unraveling the dynamics of magnetization in topological insulator-ferromagnet heterostructures via spin-orbit torque

npj Spintronics
Spin–orbit coupling is a relativistic effect coupling the orbital angular momentum with the spin, which determines the physical properties of condensed matter.
Taekoo Oh, Naoto Nagaosa
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Current-induced torques in textured Rashba ferromagnets

, 2012
In systems with small spin-orbit coupling, current-induced torques on the magnetization require inhomogeneous magnetization textures. For large spin-orbit coupling, such torques exist even without gradients in the magnetization direction.
E. I. Rashba, E. van der Bijl, R. A. Duine   +2 more
core   +1 more source

Tunable spin-charge conversion through topological phase transitions in zigzag nanoribbons [PDF]

, 2016
We study spin-orbit torques and charge pumping in magnetic quasi-one dimensional zigzag nanoribbons with hexagonal lattice, in the presence of large intrinsic spin-orbit coupling. Such a system experiences topological phase transition from a trivial band
Li, Hang, Manchon, Aurelien
core   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Collapse of spin-orbit coupled Bose-Einstein condensates

, 2015
A finite-size quasi two-dimensional Bose-Einstein condensate collapses if the attraction between atoms is sufficiently strong. Here we present a theory of collapse for condensates with the interatomic attraction and spin-orbit coupling.
Ban, Yue, Chen, Xi, Mardonov, Sh., Muga, J. G., Sherman, E. Ya., Wang, Hong-Wei   +5 more
core   +1 more source

Transport through a band insulator with Rashba spin-orbit coupling: metal-insulator transition and spin-filtering effects [PDF]

, 2009
We calculate the current-voltage characteristic of a one-dimensional band insulator with magnetic field and Rashba spin-orbit coupling which is connected to nonmagnetic leads.
Hayn, Roland, Japaridze, George, Jonckheere, Thibaut, Martin, Thierry   +3 more
core   +3 more sources

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Spin-relaxation times exceeding seconds for color centers with strong spin–orbit coupling in SiC

New Journal of Physics, 2020
Spin-active color centers in solids show good performance for quantum technologies. Several transition-metal defects in SiC offer compatibility with telecom and semiconductor industries.
Carmem M Gilardoni, Tom Bosma, Danny van Hien, Freddie Hendriks, Björn Magnusson, Alexandre Ellison, Ivan G Ivanov, N T Son, Caspar H van der Wal   +8 more
doaj   +1 more source