Results 31 to 40 of about 10,835 (274)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Wind-Induced Responses of Nonlinear Angular Motion for a Dual-Spin Rocket

Aerospace
Fin-stabilized guided rockets exhibit ballistic characteristics such as low initial velocity, high flight altitude, and long flight duration, which render their impact point accuracy and flight stability highly susceptible to the influence of wind.
Jianwei Chen, Liangming Wang, Zhiwei Yang   +2 more
doaj   +1 more source

Paradoxical popups: Why are they hard to catch?

, 2008
Even professional baseball players occasionally find it difficult to gracefully approach seemingly routine pop-ups. This paper describes a set of towering pop-ups with trajectories that exhibit cusps and loops near the apex.
A. Terry Bahill, Adair R. K., Alan M. Nathan, David G. Baldwin, Michael K. McBeath, Smits A. J., Tavares G., Watts R. G.   +7 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

The Kinematics of Falling Pterocymbium Tinctorium Seeds

International Scholastic Journal of Science, 2020
Pterocymbium tinctorium (Thai:ปออีเก้ง, Por-Ae-Keang ) is a tree found in Thailand and other Southeast Asian countries. The fruit, containing a single seed with an attached single wing extending to one side and a hollow boat-shaped structure that braces
Akio Ikegami, Napol Pornananrat, Chirapot Vuthipraphan, Thasphol Boonvilai   +3 more
doaj  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

An Approach for Balanced Power and Maneuvering Assistance Using Rotor Sails

Journal of Marine Science and Engineering
Wind-assisted ship propulsion (WASP) systems are gaining importance due to their contribution to reducing greenhouse gases and saving fuel. Existing studies mostly focus on the aerodynamics of sailing systems, the integration of sails and ship dynamics ...
Cem Güzelbulut, Serdar Kaveloğlu
doaj   +1 more source

Kesediaan pelajar dari aspek kemahiran teknikal terhadap pembentukan kebolehkerjaan di Kolej Vokasional Wilayah Selatan [PDF]

, 2015
Graduan yang menganggur terus menjadi masalah yang semakin meruncing di Malaysia. Terdapat majikan yang menganggap kompetensi akademik sahaja tidak mencukupi dan mula meminta institusi pendidikan tinggi untuk menghasilkan graduan yang dilengkapi ...
Hanafi., Suhaili
core  

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source