Results 91 to 100 of about 81,152 (336)

Activation of Kir4.1 Channels by 2‐D08 Promotes Myelin Repair in Multiple Sclerosis

Advanced Science, EarlyView.
Multiple sclerosis causes myelin loss and neurological dysfunction. This study shows that 2‐D08, a small molecule targeting Kir4.1 channels, promotes OPCs differentiation via FYN tyrosine kinase phosphorylation and the FYN/MYRF pathway. It significantly improves myelin repair and motor deficits in EAE mice and marmosets, highlighting its potential as a
Mingdong Liu, Shengyu Jin, Xin Fu, Chong Xie, Yi Chen, Liangtang Chang, Yongheng Fan, Donghua He, Xiaoqi Hong, Xi Shen, Xiaoli Zheng, Qiyue Wang, Dao Shi, Fangyuan Li, Daishun Ling, Yangtai Guan, Neng Gong, Xiaoping Tong   +17 more
wiley   +1 more source

Local anaesthesia efficacy as postoperative analgesia for open shoulder instability surgery. a prospective randomised controlled study [PDF]

, 2012
Background and objectives: The aim of present study was to evaluate for the first time, the clinical effect of local anaesthetic infiltration as postoperative analgesia in open shoulder surgery for anterior-inferior instability.
Caricati Alessio, Costantini Alberto, De Vita Andrea, Di Donato A, Fontana Costantino, Lancia Fabrizio, Rocco Monica   +6 more
core   +1 more source

Long Term High‐Salt Diet Induces Cognitive Impairments via Down‐Regulating SHANK1

Advanced Science, EarlyView.
The study identifies a novel mechanistic link between long‐term HS diet and cognitive impairment, wherein PKA/CREB axis inactivation leads to SHANK1 reduction, synaptic damage, and cognitive deficits. Abstract High‐salt (HS) diet is an established risk factor for cognitive impairment, but the underlying mechanisms remain unclear.
Cuiping Guo, Yuanyuan Li, Wensheng Li, Tongrui Wu, Yi Liu, Yacoubou Abdoul Razak Mahaman, Jianzhi Wang, Rong Liu, Wei Liu, Hui Shen, Xiaochuan Wang   +10 more
wiley   +1 more source

Body image distortions following spinal cord injury [PDF]

, 2012
Background: Following spinal cord injury (SCI) or anaesthesia, people may continue to experience feelings of the size, shape, and posture of their body, suggesting that the conscious body image is not fully determined by immediate sensory signals.
Fuentes, C.T., Haggard, P., Longo, Matthew R., Pazzaglia, M., Scivoletto, G.   +4 more
core   +1 more source

Nano‐Anesthetics Regulate Neuro‐Immune Interaction for Treating Neuropathic Pain

Advanced Science, EarlyView.
Ce‐UiO‐66‐Bupivacaine (CUB) demonstrates triple therapeutic innovation: 1) Sustained analgesia with ROS scavenging synergistically resolves neuropathic pain; 2) Microglia/astrocyte polarization switch reprograms the pro‐regenerative immune microenvironment; 3) CGRP‐TSP‐1 axis activation couples inflammation suppression to axon regeneration, defining a ...
Yue Wang, Xiuru Ji, Yu Sun, Han Wang, Ting Wang, Tao Luo, Yanyong Cheng, Jia Yan, Dalong Ni, Hong Jiang   +9 more
wiley   +1 more source

Functional differences between neurochemically defined populations of inhibitory interneurons in the rat spinal dorsal horn [PDF]

, 2013
In order to understand how nociceptive information is processed in the spinal dorsal horn we need to unravel the complex synaptic circuits involving interneurons, which constitute the vast majority of the neurons in laminae I–III. The main limitation has
Locke, S., Polgár, Erika, Sardella, T.C.P., Tiong, S.Y.X., Todd, A.J., Watanabe, M.   +5 more
core   +1 more source

A Myelin Debris Cleaner for Spinal Cord Injury Recovery: Polycaprolactone / Cell Membrane Assembled Scaffolds

Advanced Science, EarlyView.
pMM‐PCL, made up of pretreated macrophage menbrane and polycaprolactone, boasts the adsorption of harmful myelin debris in the microenvironment of spinal cord injury. Abstract After spinal cord injury (SCI), a mass of myelin debris derived from injured myelin sheath will be consistently generated and induce macrophages to be foam cells.
Yuchen Zhou, Tao Xu, Yiyan Zhou, Nuo Chen, Zhengchao Wu, Zongze Yang, Changwei Yang, Xiaoqing Chen   +7 more
wiley   +1 more source

Ten Years of Experience Training Non-Physician Anesthesia Providers in Haiti. [PDF]

, 2009
Surgery is increasingly recognized as an effective means of treating a proportion of the global burden of disease, especially in resource-limited countries. Often non-physicians, such as nurses, provide the majority of anesthesia; however, their training
AF Ouro-Bang’na Maman, AF Smith, BL Grundy, D Hansen, D Ozgediz, DC Simonson, F Mullan, F Mullan, I Walker, IA Walker, JP Abenstein, K Chu, KA Torgersen, Kathryn Chu, LC Ivers, M Philips, M Zimmerman, Miguel Trelles, MN Cherian, MS McAuliffe, Nathan Ford, Organization PAH, P Adnet, P Chatterjee, PE Farmer, Peter Rosseel, S Jochberger, SC Hodges, Seydouba Guilavogui, T Lokossou, TG Weiser, WA Tweed   +31 more
core   +2 more sources

Sustained‐Release Photothermal Microneedles for Postoperative Incisional Analgesia and Wound Healing via Hydrogen Therapy

Advanced Science, EarlyView.
This study introduces a novel transdermal delivery system of molecular hydrogen for postoperative pain relief and wound healing. This system utilizes sustained‐release photothermal microneedles to integrate hydrogen‐releasing nanoparticles and temperature‐responsive microspheres, achieving acid‐responsive hydrogen release and controlled drug release ...
Aining Zhang, Xue Jiang, Bingrui Xiong, Jiayi Chen, Xin Liu, Siyuan Wang, Bofu Li, Mian Peng, Wei Li   +8 more
wiley   +1 more source

Prophylactic crystalloids or prophylactic crystalloids with ephedrine: Comparison of hemodynamic effects during caesarean section under spinal anaesthesia using 0.5% bupivacaine

Journal of Obstetric Anaesthesia and Critical Care, 2017
Background: Spinal anaesthesia is usually chosen for caesarean section not only because of its faster onset and reliability but also because general anaesthesia is associated with more complications.
Bharath Kumar Hegde, Manjunath Timmappa Bhat   +1 more
doaj   +1 more source