Results 151 to 160 of about 1,038,908 (406)

PIEZO1‐GPX4 Axis Mediates Mechanical Stress‐Induced Vertebral Growth Plate Dysplasia via Ferroptosis Activation

Advanced Science, EarlyView.
Mechanical stress activates PIEZO1 in vertebral growth plate chondrocytes, triggering ferroptosis through direct binding and inhibition of GPX4. This axis promotes lipid peroxidation and pathological ossification, accelerating spinal deformities. Clinical and genetic evidence (Piezo1‐cKO) confirms its role in scoliosis progression.
Fei Chen, Fushuai Peng, Shuqing Chen, Yukun Du, Jianyi Li, Yuanyuan Fan, Zichen Cui, Guanghui Gu, Han Zhang, Zhensong Jiang, Guodong Wang, Xingzhi Jing, Jun Dong, Tao Li, Yongming Xi   +14 more
wiley   +1 more source

Neural Substrates of Chronic Pain in the Thalamocortical Circuit [PDF]

, 2011
Chronic pain (CP), a pathological condition with a large repertory of signs and symptoms, has no recognizable neural functional common hallmark shared by its diverse expressions.
Antonio G. Zippo, Gabriele E. M. Biella, Gian Carlo Caramenti, Maurizio Valente, Riccardo M. Storchi   +4 more
core   +1 more source

Long Term High‐Salt Diet Induces Cognitive Impairments via Down‐Regulating SHANK1

Advanced Science, EarlyView.
The study identifies a novel mechanistic link between long‐term HS diet and cognitive impairment, wherein PKA/CREB axis inactivation leads to SHANK1 reduction, synaptic damage, and cognitive deficits. Abstract High‐salt (HS) diet is an established risk factor for cognitive impairment, but the underlying mechanisms remain unclear.
Cuiping Guo, Yuanyuan Li, Wensheng Li, Tongrui Wu, Yi Liu, Yacoubou Abdoul Razak Mahaman, Jianzhi Wang, Rong Liu, Wei Liu, Hui Shen, Xiaochuan Wang   +10 more
wiley   +1 more source

Correlative factors of post-dural puncture backache in cesarean section

فصلنامه دانشگاه علوم پزشکی جهرم, 2013
Introduction: Spinal anesthesia is an optional method chosen for cesarean section. One main reason for the decline of this method is backache. This study was conducted to investigate the factors associated with post-dural puncture backache in cesarean ...
Saeed Pasban Noghabi, Aarash Hamzei, Hossein Nazemi, Hossein Kamran Bilandy   +3 more
doaj  

Apprehension of paraplegia after undergoing spinal anesthesia in the central region population of Saudi Arabia: A cross-sectional study

Journal of Pharmacy and Bioallied Sciences
Aim: The aim of the present study was to determine the prevalence of paraplegia-related fear in spinal anesthesia among the general population in the central region of Saudi Arabia.
Faris Suleiman Saleh Aldobekhi, Manal M Almutairi, Mohammed H Alanazi, Badah M Aldawsari, Sarah S Almutairi, Abdulkarim K Alenazi, Abdulazizludba N Binmuhareb, Ghadi A Alfadhil, Shouq Y Alaoufi, Abdullah O Alqahtani   +9 more
doaj   +1 more source

Epigenetic Regulation of DAPK1 and Netrin‐1 Drives Diabetic Encephalopathy

Advanced Science, EarlyView.
This study identifies a microRNA (miR)‐216a‐5p/death‐associated protein kinase 1 (DAPK1)/hepatocyte nuclear factor 1 homeobox A (HNF1A)/Netrin‐1 signaling axis in diabetic encephalopathy (DE). In leptin receptor‐deficient (db/db) and streptozotocin (STZ)‐induced diabetic mice, reduced miR‐216a‐5p increases DAPK1 expression, disrupting HNF1A binding to ...
Yang Zhou, Jia‐Xin Kou, Kai Zheng, Zi‐Xuan Guo, Hong‐Wei Fan, Wen‐Lian Li, Lu‐Lu Chu, Jing‐Wen Yin, Li‐Jie Liu, Nadezhda Brazhe, Zhi‐Gao Xiang, Feng Hu, Kai Shu, Ling‐Qiang Zhu, Dan Liu   +14 more
wiley   +1 more source

Effect of Spinal Anesthesia on Blood Pressure During Cesarean Section in Private Indonesian Hospital

Majalah Kedokteran Bandung
The 2018 Indonesian Basic Health Research Data presented an increase in the number of cesarean sections from the previous years, with an increase of 17.6%.
Nassya Putri Nanmi, Husnul Lailly, Ita Armyanti, Poppy Novitarini, Willy Handoko   +4 more
doaj   +1 more source

THE SPREAD OP DRUGS USED FOR SPINAL ANESTHESIA [PDF]

, 1956
Tetsuo Kitahara, Shinnosuke Kuri, Jun Yoshida   +2 more
openalex   +1 more source

Cationic Peptoids for Systemic In Vivo Cartilage‐Targeting

Advanced Science, EarlyView.
Systemically‐dosed Cy5‐labeled cationic peptoid probe (NlysO)7 (yellow) binds to the cartilage's glycosaminoglycan content in vivo across the entire body of a neonatal mouse imaged by light sheet fluorescence microscopy, revealing fluorescence uptake in generic cartilage as well as the developing and ossifying bones.
Chaonan Zhang, Rongmao Qiu, Yongjie Huang, Yinghua Liu, Kui Huang, Suwen Zhao, Yang Li   +6 more
wiley   +1 more source

Circulatory Responses to Spinal and Caudal Anesthesia in Hypertension [PDF]

, 1948
A. C. Corcoran, R. Taylor, Irvine H. Page   +2 more
openalex   +1 more source