Results 41 to 50 of about 66,319 (312)

Protocol to prepare mouse spinal cord for patch-clamp and histology experiments

STAR Protocols, 2023
Summary: The spinal cord is a part of the central nervous system located within the spinal canal of the vertebrae. Here, we present a protocol to prepare mouse spinal cord sections for patch-clamp and histology experiments.
Sang-Hyeon Ju, Jong-Woo Sohn
doaj   +1 more source

Activation of Spinal Astrocyte α2A Adrenoceptors Protects Against Sepsis‐Induced Heart Injury Through Inhibition of GABAergic Neuronal Necroptosis

Advanced Science, EarlyView.
The study in this paper found that activating the α2A receptors of astrocytes in the thoracic spinal cord can reduce the release of inflammatory factors, thereby decreasing the necroptosis of GABAergic neurons and consequently alleviating myocardial injury caused by sepsis.
Ruilin He, Bin Wu, Liuhu Han, Mingde Li, Wenli Guo, Jiajing Fu, Bin Mei, Eric R. Gross, Xuesheng Liu, Yao Lu   +9 more
wiley   +1 more source

Three-dimensional simulation of the lumbar spine under lumbar spinal stenosis with different sizes of spinal canal

Partial Differential Equations in Applied Mathematics
In this paper, we investigate the effect of body weight on the lumbar spine with different spinal canal sizes when humans bend down by using the finite element method. Lumbar spinal stenosis is the narrowing of the spinal canal.
Din Prathumwan, Inthira Chaiya, Kamonchat Trachoo   +2 more
doaj   +1 more source

Foxj1a is expressed in ependymal precursors, controls central canal position and is activated in new ependymal cells during regeneration in zebrafish [PDF]

Open Biology, 2017
Zebrafish are able to regenerate the spinal cord and recover motor and sensory functions upon severe injury, through the activation of cells located at the ependymal canal.
Ana Ribeiro, Joana F. Monteiro, Ana C. Certal, Ana M. Cristovão, Leonor Saúde   +4 more
doaj   +1 more source

Cancer Neuroscience: Decoding Neural Circuitry in Tumor Evolution for Targeted Therapy

Advanced Science, EarlyView.
This review highlights the pivotal role of the nervous system in cancer progression, emphasizing how neural–tumor interactions—via synaptic signaling, neurotransmitters, and paracrine factors—reshape the tumor microenvironment. It introduces cancer neuroscience as an emerging field and proposes integrating advanced tools such as AI and optogenetics to ...
Mengyu Yuan, Rongjiao Xi, Yong Kang, Ming‐jie Kuang, Xiaoyuan Ji   +4 more
wiley   +1 more source

Directed Self‐Assembly of Magnetic Bioceramic Deep Inside Dentinal Tubules May Alleviate Dental Hypersensitivity

Advanced Science, EarlyView.
Magnetically guided bioceramic nanoparticles (“CalBots”) achieve deep dentinal tubule occlusion via directed self‐assembly under externally applied magnetic field. Various visualization techniques and a novel mouse behavioral assay indicate that CalBot‐induced plugs may reduce dentinal sensitivity, offering a promising strategy for future dentin ...
Shanmukh Peddi, Prajwal Hegde, Prannay Reddy, Anaxee Barman, Arnab Barik, Debayan Dasgupta, Ambarish Ghosh   +6 more
wiley   +1 more source

Developmental Lumbar Spinal Canal Stenosis and Severity of Radiculopathy

The Annals of African Surgery, 2019
Background: The severity of radiculopathy is varied and may not concur with MRI findings. Large disc bulges may elicit fewer symptoms than smaller bulges. This was postulated to be due to the size of the canal.
Muthuuri Jamlick
doaj  

Efficacy of OLIF combined with pedicle screw internal fixation for lumbar spinal stenosis on spinal canal changes before and after surgery

Journal of Orthopaedic Surgery and Research, 2023
Purpose The purpose of the study was to evaluate the efficacy of OLIF combined with pedicle screw internal fixation in the treatment of lumbar spinal stenosis by assessing the changes in spinal canal before and after surgery.
Wangbing Xu, Weibing Liu, Faming Zhong, Yu Peng, Xin Liu, Liangkun Yu   +5 more
doaj   +1 more source

Single‐Cell Dissection of the Biological Function and Molecular Features Underlying the Micropeptide LSMEM1 in Kidney

Advanced Science, EarlyView.
LSMEM1, an evolutionarily conserved micropeptide with extreme hydrophobicity (aliphatic index═113) and dynamic amphiphilicity (GRAVY═0.017), features a strong α‐helical transmembrane anchor (residues 64‐86). Single‐cell analysis reveals its critical role in renal lipid homeostasis.
Peimin Liu, Hong Zhang, Shanzhi Yang, Jiaoqing Li, Danfeng Wu, Haosen Xu, Huan Jiang, Yi Jing, Guoxiang Jin, Ruobing Liu, Ning Fan, Xiaoyan Bai   +11 more
wiley   +1 more source

Clinical features of ligamentosis in lumbar spinal stenosis in patients of different agе

Ukrainian Neurosurgical Journal, 2012
Introduction. Ligamentosis of lumbar spinal canal are rare and not well investigated pathology.Materials and methods. From our patients with lumbar spinal stenosis we took that, which had changes in spinal ligamentsResults.
Yuriy Pedachenko, Elena Krasilenko
doaj   +1 more source