Results 181 to 190 of about 29,285 (251)

Compound heterozygous SLC12A5 variants expand the molecular and functional spectrum of KCC2‐developmental and epileptic encephalopathy

Epilepsia, EarlyView.
Overview of the multimodal experimental approach integrating clinical, genetic, in silico, and in vitro investigations. Clinical: Representative EEG recording setup and ictal traces from affected patients. Genetic: Pedigrees for Families A and B highlighting the inheritance of the four identified SLC12A5 variants (A1, A2, B1, B2).
Mira Hamze, Robyn Whitney, Dorothée Ville, Nathalie Villeneuve, Anna‐Maria Hartmann, Lisa Becker, Jens Hausmann, Jinwei Zhang, Cathy Brier, Lucie I. Pisella, Perrine Friedel, Audrey Labalme, Eudeline Alix, Nicolas Chatron, Damien Sanlaville, Sylvie Gory‐Fauré, Eric Denarier, Christophe Porcher, Gaetan Lesca, Igor Medina   +19 more
wiley   +1 more source

No increased risk of spinal cerebrospinal fluid leak after spinal manipulative therapy: A retrospective cohort study. [PDF]

PM R
Trager RJ, Labak CM, Baumann AN, Snodgrass TH, Cupler ZA.   +4 more
europepmc   +1 more source

Genetic epilepsies with myoclonic seizures: Mechanisms and syndromes

Epilepsia Open, EarlyView.
Abstract Genetic epilepsy with myoclonic seizures encompasses a heterogeneous spectrum of conditions, ranging from benign and self‐limiting forms to severe, progressive disorders. While their causes are diverse, a significant proportion stems from genetic abnormalities.
Antonietta Coppola, Marica Rubino, Antonella Riva, Pasquale Striano   +3 more
wiley   +1 more source

Impact of lower extremity amputation on spinal health: a cohort study of back pathologies in transfemoral and transtibial amputees. [PDF]

J Spine Surg
Amirouche F, Lami E, Mungalpara N, Mzeihem M.   +3 more
europepmc   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Bridging the gap: The experiences and needs of people with spinal cord injury when transitioning out of inpatient rehabilitation. [PDF]

S Afr J Physiother
Floudiotis C, Pilusa SI.
europepmc   +1 more source

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

Equine Veterinary Journal, EarlyView.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska, Jowita Grzędzicka‐Agko, Paula Kiełbik, Michał Trela, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Glucagon-like peptide-1 receptor agonist use and clinical outcomes after posterior cervical spinal fusion for degenerative pathologies: A large cohort retrospective analysis. [PDF]

N Am Spine Soc J
Rajkovic C, Jain A, Shafi M, Omobhude O, Azad T, Carpenter A, Witham TF, Kinon MD, Wainwright JV.   +8 more
europepmc   +1 more source

AI‐enabled biomimetic flexible pressure sensors for high‐precision gait monitoring and rehabilitation assessment

FlexMat, EarlyView.
A biomimetic multilayer capacitive sensor‐integrated insole enables high‐resolution plantar pressure mapping for intelligent gait analysis. Featuring ultrahigh sensitivity, wide detection range, and long‐term stability, the system leverages AI algorithms to decode spatiotemporal pressure signals, achieving accurate recognition of postoperative ...
Yingchun Li, Yarong Ding, Kaixin Lei, Yuze Zhang, Zhenhua Lin, Jiachun Sun, Kaitai Guo, Yang Zheng, Shaozhe Tan, Xuesi Zhang, Xinyue Li, Yue Hao, Xiangning Li, Yannan Liu, Jingjing Chang   +14 more
wiley   +1 more source

'There's No Improvement. I'm Still Bedridden': Recovery After Hospital Admission for Low Back Pain and Alignment With Patient Expectations. [PDF]

Musculoskeletal Care
Orlando JF, Beard M, Burke ALJ, Guerin M, Kumar S.   +4 more
europepmc   +1 more source