Results 131 to 140 of about 1,533,125 (359)

A Brain–Spinal Interface Alleviating Gait Deficits after Spinal Cord Injury in Primates

Nature, 2016
Spinal cord injury disrupts the communication between the brain and the spinal circuits that orchestrate movement. To bypass the lesion, brain–computer interfaces have directly linked cortical activity to electrical stimulation of muscles, and have thus ...
M. Capogrosso, T. Milekovic, D. Borton, Fabien B. Wagner, E. M. Moraud, Jean-Baptiste Mignardot, Nicolas Buse, Jérôme Gandar, Q. Barraud, David Xing, Elodie Rey, S. Duis, Jianzhong Yang, W. K. D. Ko, Qin Li, P. Detemple, T. Denison, S. Micera, E. Bézard, J. Bloch, G. Courtine   +20 more
semanticscholar   +1 more source

Engineering the Future of Restorative Clinical Peripheral Nerve Surgery

Advanced Healthcare Materials, EarlyView.
What if damaged nerves could regenerate more effectively? This review unveils cutting‐edge strategies to restore nerve function, from biomaterial scaffolds and bioactive molecules to living engineered tissues. By accelerating axonal regrowth, preserving Schwann cells, and enhancing connectivity, these approaches are reshaping nerve repair—offering new ...
Justin C. Burrell, Zarina S. Ali, Eric L. Zager, Joseph M. Rosen, Mykhailo M. Tatarchuk, D. Kacy Cullen   +5 more
wiley   +1 more source

Impaired transmission in the corticospinal tract and gait disability in spinal cord injured persons [PDF]

, 2010
Rehabilitation following spinal cord injury is likely to depend on recovery of corticospinal systems. Here we investigate whether transmission in the corticospinal tract may explain foot drop (inability to dorsiflex ankle) in persons with spinal cord ...
Barthélemy, Dorothy, Barthélemy, Dorothy, Biering-Sørensen, Fin, Biering-Sørensen, Fin, Conway, Bernard A, Conway, Bernard A., Holm-Nielsen, Jens Bo, Knudsen, Hanne, Knudsen, Hanne, Lundell, Hans Magnus Henrik, Lundell, Henrik, Nielsen, Jens Bo, Willerslev-Olsen, Maria, Willerslev-Olsen, Maria   +13 more
core   +1 more source

Case of a 16‐Year‐Old Boy With Headache, Vomiting, and Behavioral Changes

Annals of Clinical and Translational Neurology, EarlyView.
Kundian Guo, Zhen Hong
wiley   +1 more source

Engineered Chitosan‐Derived Nanocarrier for Efficient siRNA Delivery to Peripheral and Central Neurons

Advanced Healthcare Materials, EarlyView.
This study introduces a novel chitosan‐based nanocarrier functionalized with a neurotropic protein for efficient siRNA delivery to neurons. The polyplexes demonstrate enhanced neuronal binding, retrograde transport, and PTEN silencing, promoting axonal outgrowth.
Ana P. Spencer, Adriana Vilaça, Miguel Xavier, Rafael Santos, Ariel Ionescu, María Lázaro, Victoria Leiro, Eran Perlson, Sofia C. Guimarães, Ben M. Maoz, Ana P. Pêgo   +10 more
wiley   +1 more source

Exploring the relationship of clinical walking tests with 8-months inertial measurement unit (IMU)-based real world mobility tracking in stroke and spinal cord injury survivors

Neurological Research and Practice
Background Mobility is crucial for participation and quality of life in individuals with sensorimotor impairments, yet scientific evidence on its course in real-world settings is limited.
Andreas Hug, Tamara Spingler, Viola Pleines, Laura Heutehaus, Mircea Ariel Schoenfeld, Björn Hauptmann, Jürgen Moosburger, Roland Thietje, Oliver Pade, Wolfgang Rössy, Klaus Stecker, Jochen Klucken, Tiziana Daniel, Michel Wensing, Cornelia Hensel, Rüdiger Rupp, Norbert Weidner   +16 more
doaj   +1 more source

Generative diffeomorphic atlas construction from brain and spinal cord MRI data [PDF]

arXiv, 2017
In this paper we will focus on the potential and on the challenges associated with the development of an integrated brain and spinal cord modelling framework for processing MR neuroimaging data. The aim of the work is to explore how a hierarchical generative model of imaging data, which captures simultaneously the distribution of signal intensities and
arxiv  

Electrophysiological Guidance of Epidural Electrode Array Implantation over the Human Lumbosacral Spinal Cord to Enable Motor Function after Chronic Paralysis. [PDF]

, 2019
Epidural electrical stimulation (EES) of the spinal cord has been shown to restore function after spinal cord injury (SCI). Characterization of EES-evoked motor responses has provided a basic understanding of spinal sensorimotor network activity related ...
Beck, Lisa A, Brown, Desmond A, Calvert, Jonathan S, Edgerton, V Reggie, Gerasimenko, Yury P, Gill, Megan L, Grahn, Peter J, Lavrov, Igor A, Lee, Kendall H, Linde, Margaux B, Lopez, Cesar, Sayenko, Dimitry G, Strommen, Jeffrey A, Van Straaten, Meegan G, Veith, Daniel D, Zhao, Kristin D   +15 more
core  

Biomimetic Scaffolds Enhance iPSC Astrocyte Progenitor Angiogenic, Immunomodulatory, and Neurotrophic Capacity in a Stiffness and Matrix‐Dependent Manner for Spinal Cord Repair Applications

Advanced Healthcare Materials, EarlyView.
Through tuning biomimetic scaffold stiffness and matrix composition the reparative capacity of astrocyte progenitors is enhanced. Soft, collagen‐IV/fibronectin‐functionalized scaffolds promote progenitor growth while improving angiogenic, immunomodulatory, and neurotrophic capacity in a stiffness and matrix‐dependent manner, demonstrating the impact of
Cian O'Connor, Ian Woods, Sarah F. McComish, Sean Kerr, Matthew McGrath, Juan Carlos Palomeque Chávez, Jack Maughan, Tara McGuire, Maeve A. Caldwell, Adrian Dervan, Fergal J. O'Brien   +10 more
wiley   +1 more source

Increased Incidence of Depression and Chronic Pain in Traumatic Spinal Cord Injury Patients With Pre-Injury Alcohol Use Disorder: Longitudinal Analysis of Insurance Claim Database

Neurotrauma Reports
Alcohol use disorder (AUD) increases risk of traumatic spinal cord injury (SCI) and is associated with depression, anxiety, and chronic pain. Given that these neuropsychiatric morbidities are frequently observed in SCI patients, the effects of pre-injury
Beatrice Ugiliweneza, Dengzhi Wang, Benjamin Rood, Maxwell Boakye, Camilo Castillo, Michal Hetman   +5 more
doaj   +1 more source