Results 161 to 170 of about 1,229,305 (356)

Inhibition of SLC11A1‐Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke

Advanced Science, EarlyView.
Genetic and pharmacological inhibition of SLC11A1 functioning as an H+/Fe2+ antiporter–mediated lysosomal iron accumulation in microglia promotes lysosomal lumen acidification, increases CTSD expression, enhances lysosomal myelin debris uptake and degradation, and promotes repair following white matter stroke. ABSTRACT White matter stroke (WMS) results
Lingling Qiu, Yajie Zhang, Yushi Tang, Hongli Hu, Ying Zhang, Junwen Xue, Hao Wang, Yecheng Wang, Chunfeng Liu, Jia Jia, Jian Cheng, Yongjun Cao   +11 more
wiley   +1 more source

The 2019 revision of the International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)—What’s new?

Spinal Cord, 2019
R. F. S. P. W. D. E. J. L. S. A. M. J. M. G. M. Rüdig Betz Biering-Sørensen Burns Donovan Graves Guest J, R. Betz, F. Biering-Sørensen, S. Burns, W. Donovan, D. Graves, J. Guest, L. Jones, S. Kirshblum, A. Krassioukov, M. Mulcahey, M. Schmidt Read, G. Rodriguez, R. Rupp, C. Schuld, K. Tansey, K. Walden   +16 more
semanticscholar   +1 more source

Intraoperative Neurophysiological Monitoring for Spinal Cord Surgery [PDF]

, 2008
Karl F. Kothbauer, Chief, Division of Neurosurgery, Luzerner Kantonsispital, Lucerne   +1 more
openalex   +1 more source

Spinal cord monitoring [PDF]

Anaesthesia, 1998
openaire   +2 more sources

Parabiosis, Assembloids, Organoids (PAO)

Advanced Science, EarlyView.
This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong, Lavonda Li, Lijie Yan, Long Bai, Jiacan Su, Xingcai Zhang   +5 more
wiley   +1 more source

The Effectiveness of Various Types of Electrical Stimulation of the Spinal Cord for Chronic Pain in Patients with Postherpetic Neuralgia: A Literature Review [PDF]

, 2023
E D Isagulyan, Vasily Tkachenko, Denis Semenov, Svetlana Asriyants, Е В Дорохов, Elizaveta Makashova, K S Aslakhanova, Alexei Tomskiy   +7 more
openalex   +1 more source

Microglial HVCN1 Deficiency Improves Movement and Survival of SOD1G93A ALS Mice by Enhancing Microglial Migration and Neuroprotection

Advanced Science, EarlyView.
Hydrogen voltage gated channel 1 (HVCN1) is upregulated in microglia of both ALS patients and its mouse model. HVCN1 deficiency enhances microglial migration via suppressing Akt signaling, promotes neurotrophic capacity and motor function, and prolongs survival of the SOD1G93A ALS mice. This study identifies HVCN1 as a novel, promising druggable target
Fan Wang, Ke‐Yu Zhang, Lang‐Jian Zhu, Wei‐Jue Li, Yang Wu, Xiang Gao, Xiao‐Ru Ma, Xiu‐Hua Yin, Jian‐Bin Wu, Xiao‐Kang Ye, Zhao‐Jun Dong, Di‐Xian Wang, Zhe Zhou, Shao‐Dong Wang, Lei Han, Zhi‐Nong Jiang, Jing‐Wei Zhao   +16 more
wiley   +1 more source

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

Advanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu   +15 more
wiley   +1 more source

Comparative outcomes of spinal cord stimulation for neuropathic pain: peripheral nerve versus spinal cord lesions. [PDF]

Neurosurg Rev
Fitzrol DN, Sitthinamsuwan B, Jirachaipitak S, Euasobhon P, Zinboonyahgoon N, Nunta-Aree S.   +5 more
europepmc   +1 more source

Interplay between subthalamic nucleus and spinal cord controls parkinsonian nociceptive disorders [PDF]

Keri‐Ann Charles, Elba Molpeceres Sierra, Rabia Bouali‐Benazzouz, Houyam Tibar, Khalid Oudaha, Frédéric Naudet, Alexia Duveau, Pascal Fossat, Abdelhamid Benazzouz   +8 more
openalex   +1 more source