Results 11 to 20 of about 1,183,713 (344)

Neonatal microglia-organized scar-free spinal cord repair

Nature, 2020
It is thought that spinal cord injury triggers scar formation with little axon regeneration in mammals1–4. Here we report that in neonatal mice, a crush injury to the spinal cord leads to a scar-free healing that permits the growth of long projecting ...
Yi Li, Xuelian He, R. Kawaguchi, Yu Zhang, Qing Wang, Aboozar Monavarfeshani, Zhiyun Yang, Bo Chen, Zhongju Shi, Huyan Meng, Songlin Zhou, Junjie Zhu, A. Jacobi, Vivek Swarup, Phillip G. Popovich, Daniel H. Geschwind, Zhigang He   +16 more
semanticscholar   +1 more source

Spinal Cord Stimulation

Definitions, 2020
A highly invasive form of electroanalgesia used to treat various chronic pain syndromes, which resist treatment by more common means. It is also used to treat peripheral ischemia, peripheral vascular disease, complex regional pain syndrome, intractable ...

semanticscholar   +1 more source

Delayed lumbar plexus palsy due to giant psoas hematoma associated with vertebral compression fracture and direct oral anticoagulants: a case report

BMC Musculoskeletal Disorders, 2021
Background Osteoporotic vertebral compression fractures (VCFs) are commonly observed in elderly people and can be treated by conservatively with minimal risk of complications in most cases.
Chikako Ishii, Miki Komatsu, Kota Suda, Masahiko Takahata, Satoko Matsumoto Harmon, Masahiro Ota, Takamasa Watanabe, Mitsuru Asukai, Norimasa Iwasaki, Akio Minami   +9 more
doaj   +1 more source

Aquaporins in the Spinal Cord [PDF]

International Journal of Molecular Sciences, 2016
Aquaporins (AQPs) are water channel proteins robustly expressed in the central nervous system (CNS). A number of previous studies described the cellular expression sites and investigated their major roles and function in the brain and spinal cord. Among thirteen different mammalian AQPs, AQP1 and AQP4 have been mainly studied in the CNS and evidence ...
Michal Oklinski, Mariusz Skowronski, Agnieszka Skowronska, Michael Rützler, Kirsten Nørgaard, John Nieland, Tae-Hwan Kwon, Søren Nielsen   +7 more
openaire   +3 more sources

Treatment of spinal cord injury with mesenchymal stem cells

Cell & Bioscience, 2020
Background Spinal cord injury (SCI) is the damage to the spinal cord that can lead to temporary or permanent loss of function due to injury to the nerve. The SCI patients are often associated with poor quality of life.
L. L. Liau, Q. H. Looi, Wui Chuen Chia, Thayaalini Subramaniam, M. Ng, J. Law   +5 more
semanticscholar   +1 more source

Effects of gabapentin on muscle spasticity and both induced as well as spontaneous autonomic dysreflexia after complete spinal cord injury

Frontiers in Physiology, 2012
We recently reported that the neuropathic pain medication, gabapentin (GBP; Neurontin), significantly attenuated both noxious colorectal distension (CRD)-induced autonomic dysreflexia (AD) and tail pinch-induced spasticity compared to saline-treated ...
Alexander G. Rabchevsky, Alexander G. Rabchevsky, Samir P. Patel, Travis S. Lyttle, Khalid C. Eldahan, Christopher R. O'Dell, Yi eZhang, Yi eZhang, Phillip G. Popovich, Phillip G. Popovich, Patrick H. Kitzman, Patrick H. Kitzman, Kevin D. Donohue   +12 more
doaj   +1 more source

Acute and non-resolving inflammation associate with oxidative injury after human spinal cord injury

Brain : a journal of neurology, 2020
In spinal cord injury, the initial mechanical insult may be followed by progressive cord atrophy and neurodegeneration. Zrzavy et al. characterize innate and adaptive inflammatory responses in human spinal cord injury, and show that oxidative injury is a
Tobias Zrzavy, C. Schwaiger, I. Wimmer, T. Berger, J. Bauer, O. Butovsky, J. Schwab, H. Lassmann, R. Höftberger   +8 more
semanticscholar   +1 more source

Spinal Cord Electrophysiology [PDF]

Journal of Visualized Experiments, 2010
The neonatal mouse spinal cord is a model for studying the development of neural circuitries and locomotor movement. We demonstrate the spinal cord dissection and preparation of recording bath artificial cerebrospinal fluid used for locomotor studies. Once dissected, the spinal cord ventral nerve roots can be attached to a recording electrode to record
Benjamin W. Gallarda, Benjamin W. Gallarda, William A. Alaynick, Samuel L. Pfaff, Allyn Meyer   +4 more
openaire   +3 more sources

Traumatic Spinal Cord Injury: An Overview of Pathophysiology, Models and Acute Injury Mechanisms

Frontiers in Neurology, 2019
Traumatic spinal cord injury (SCI) is a life changing neurological condition with substantial socioeconomic implications for patients and their care-givers. Recent advances in medical management of SCI has significantly improved diagnosis, stabilization,
Arsalan Alizadeh, Scott Dyck, Soheila Karimi-Abdolrezaee   +2 more
semanticscholar   +1 more source

Highlight article: Neural stem cell-derived exosomes facilitate spinal cord functional recovery after injury by promoting angiogenesis

Experimental biology and medicine, 2020
Acute traumatic spinal cord injury is a devastating event without effective therapeutic approach. The feeble plasticity of spinal cord microvascular endothelial cells (SCMECs) after trauma is one of the major causes for the exacerbation of spinal cord ...
D. Zhong, Yong Cao, Chengjun Li, Miao Li, Zi-Jie Rong, Liyuan Jiang, Zhu Guo, Hongbin Lu, Jianzhong Hu   +8 more
semanticscholar   +1 more source