MAGEA6 Engages a YY1‐Dependent Transcription to Dictate Perineural Invasion in Colorectal Cancer
Advanced Science, EarlyView.This study investigates the role of MAGEA6 in perineural invasion (PNI) in colorectal cancer (CRC). MAGEA6 promotes CRC invasiveness by inhibiting YY1 ubiquitination, enhancing CXCL1 secretion, and recruiting Schwann cells. These findings highlight the potential of targeting the MAGEA6/YY1/CXCL1 axis for therapeutic strategies against PNI and tumor ...
Hao Wang +9 more
wiley +1 more source
Modulation of Radiation – Induced tumor necrosis factor α (TNF-α) Gene Expression in the Rats Spinal Cord by Melatonin [PDF]
The spinal cord is the major dose- limiting organ for radiotherapy of cancer in the head and neck region. Understanding the cellular and molecular mechanisms may help to develop strategies to either increase the radiation tolerance or to treat spinal ...
حدادی, غلامحسن +4 more
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Pyogenic infective Diseases of the Brain Spinal Cord; Meningitis; Abscess Brain; Infective Sinus Thrombosis. By Macewen William, M. D. Glasgow: James Maclehose and Sons. 1893. [PDF]
, 1894 D. Norman Grant
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Microenvironmental Modulation for Therapeutic Efficacy of Extracellular Vesicles
Advanced Science, EarlyView.Recent studies highlighted the heterogeneity of EVs and the influence of microenvironmental signals on their therapeutic efficacy. This review offers a comprehensive overview of strategies and mechanisms to optimize the therapeutic efficacy of EVs through physical, biochemical, and mechanical modulation.
Bilu Xiang +4 more
wiley +1 more source
The Locus Coeruleus‐Periaqueductal Gray GABAergic Projection Regulates Comorbid Pain and Depression
Advanced Science, EarlyView.LC‐GABA neurons exhibit elevated activity to noxious and aversive stimuli in chronic pain, and their activation alleviates pain‐ and depression‐like behaviors. While LC‐GABA neurons target LC‐NA neurons and GABA and Glu neurons in the vlPAG, they modulate the pain responses of LC‐NA neurons but regulate pain‐ and depression‐like behaviors through their
Yuan Gao +7 more
wiley +1 more source
ACCOMMODATION AND LOCAL RESPONSE IN MOTONEURONS OF TOAD'S SPINAL CORD
, 1959 Tatsunosuke Araki, Takuzo Otani
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Computational and AI‐Driven Design of Hydrogels for Bioelectronic Applications
Advanced Electronic Materials, EarlyView.This review highlights the role of AI in advancing hydrogel design for bioelectronics, exploring natural, and synthetic gels tailored for applications like wound healing, biosensing, and tissue engineering. It emphasizes the synergy between hydrogels, electronics, and AI in creating responsive, multifunctional systems, showcasing recent innovations ...
Rebekah Finster +2 more
wiley +1 more source
Brain and Behavior, Volume 12, Issue 12, December 2022., 2022 Silencing of NEFL inhibits the inflammatory response and functional recovery following spinal cord injury. Abstract Background Neurofilament light chain (NEFL) has been identified as a biomarker for spinal cord injury (SCI), but its effect and underlying mechanism in SCI remain unclear.
Hui Zhang +4 more
wiley +1 more source
The tactile centers in the spinal cord and brain of the sea robin, prionotus carolinus [PDF]
, 1907 C. Judson Herrick
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Designed Biomaterial‐Enhanced Cell Transplantation for Neural Tissue Engineering
Aggregate, EarlyView.Biomaterials offer a promising solution for cell transplantation in the central nervous system by creating a protective environment that enhances cell survival, integration, and functional recovery in preclinical models of neurological disorders. ABSTRACT Cell transplantation therapy in the central nervous system is hindered by limited survival and ...
Yun Tang +3 more
wiley +1 more source