Results 21 to 30 of about 1,229,305 (356)

Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury

Nature Communications, 2019
The role of microglia in spinal cord injury (SCI) remains poorly understood and is often confused with the response of macrophages. Here, we use specific transgenic mouse lines and depleting agents to understand the response of microglia after SCI.
V. Bellver-Landete, Floriane Bretheau, Benoit Mailhot, Nicolas Vallières, Martine Lessard, Marie-Ève Janelle, N. Vernoux, M. Tremblay, Tobias Fuehrmann, M. Shoichet, S. Lacroix   +10 more
semanticscholar   +1 more source

Cold evoked potentials elicited by rapid cooling of the skin in young and elderly healthy individuals

Scientific Reports, 2022
Cold-evoked potentials (CEPs) constitute a novel electrophysiological tool to assess cold-specific alterations in somatosensory function. As an important step towards the clinical implementation of CEPs as a diagnostic tool, we evaluated the feasibility ...
Paulina Simonne Scheuren, Natascha Nauer, Jan Rosner, Armin Curt, Michèle Hubli   +4 more
doaj   +1 more source

Moving beyond the glial scar for spinal cord repair

Nature Communications, 2019
Traumatic spinal cord injury results in severe and irreversible loss of function. The injury triggers a complex cascade of inflammatory and pathological processes, culminating in formation of a scar.
E. Bradbury, E. Burnside
semanticscholar   +1 more source

Treatment of spinal cord injury with mesenchymal stem cells

Cell & Bioscience, 2020
Background Spinal cord injury (SCI) is the damage to the spinal cord that can lead to temporary or permanent loss of function due to injury to the nerve. The SCI patients are often associated with poor quality of life.
L. L. Liau, Q. H. Looi, Wui Chuen Chia, Thayaalini Subramaniam, M. Ng, J. Law   +5 more
semanticscholar   +1 more source

Mind your step: Target walking task reveals gait disturbance in individuals with incomplete spinal cord injury

Journal of NeuroEngineering and Rehabilitation, 2022
Background Walking over obstacles requires precise foot placement while maintaining balance control of the center of mass (CoM) and the flexibility to adapt the gait patterns.
Freschta Mohammadzada, Carl Moritz Zipser, Chris A. Easthope, David M. Halliday, Bernard A. Conway, Armin Curt, Martin Schubert   +6 more
doaj   +1 more source

Single-cell transcriptomic analysis of the adult mouse spinal cord reveals molecular diversity of autonomic and skeletal motor neurons

Nature Neuroscience, 2020
The spinal cord is a fascinating structure that is responsible for coordinating movement in vertebrates. Spinal motor neurons control muscle activity by transmitting signals from the spinal cord to diverse peripheral targets.
Jacob A. Blum, Sandy L. Klemm, J. Shadrach, Kevin A. Guttenplan, Lisa Nakayama, Arwa S. Kathiria, Phuong Hoang, Olivia Gautier, Julia A. Kaltschmidt, W. Greenleaf, A. Gitler   +10 more
semanticscholar   +1 more source

Cocaine-related cervical spinal cord infarction: a case report and review of the literature

Journal of Medical Case Reports, 2022
Study design Case report. Objectives To report a clinical case of spinal cord infarction due to cocaine use. Setting Spinal Center, IRCCS Fondazione S. Lucia, Rome (Italy).
F. Pichiorri, M. Masciullo, C. Foti, M. Molinari, G. Scivoletto   +4 more
doaj   +1 more source

Limited Functional Effects of Subacute Syngeneic Bone Marrow Stromal Cell Transplantation after Rat Spinal Cord Contusion Injury

Cell Transplantation, 2016
Cell transplantation might be one means to improve motor, sensory, or autonomic recovery after traumatic spinal cord injury (SCI). Among the different cell types evaluated to date, bone marrow stromal cells (BMSCs) have received considerable interest due
Beatrice Sandner, Mareva Ciatipis, Melanie Motsch, Irina Soljanik, Norbert Weidner, Armin Blesch Ph.D.   +5 more
doaj   +1 more source

Preserved gait kinematics during controlled body unloading

Journal of NeuroEngineering and Rehabilitation, 2017
Background Body weight supported locomotor training was shown to improve walking function in neurological patients and is often performed on a treadmill.
L. Awai, M. Franz, C. S. Easthope, H. Vallery, A. Curt, M. Bolliger   +5 more
doaj   +1 more source

Flumazenil therapy for a gabapentin-induced coma: a case report

Journal of Medical Case Reports, 2021
Background Spasticity and neuropathic pain are common in patients after spinal cord injury and negatively affect patients’ quality of life. Gabapentin and baclofen are frequently used to treat these conditions. We present a flumazenil-reversed gabapentin-
M. Masciullo, F. Pichiorri, G. Scivoletto, C. Foti, M. Molinari   +4 more
doaj   +1 more source