Results 321 to 330 of about 1,533,125 (359)

Mucosal‐associated invariant T cells in rheumatic diseases.

Arthritis &Rheumatology, Accepted Article.
Mucosal‐associated invariant T (MAIT) cells are innate‐like T cells defined by their semi‐invariant T cell receptor (TCR) and restriction by the MHC class I‐related molecule (MR1). These cells are primarily activated by microbial‐derived metabolites presented by MR1 or by cytokines. Upon activation, MAIT cells rapidly produce pro‐inflammatory cytokines,
Manon Lesturgie‐Talarek, Virginie Gonzalez, Lucie Beaudoin, Noémie Sénot, Corinne Miceli‐Richard, Yannick Allanore, Agnès Lehuen, Jerôme Avouac   +7 more
wiley   +1 more source

A novel strategy for spinal cord reconstruction via vascularized allogeneic spinal cord transplantation combine spinal cord fusion. [PDF]

CNS Neurosci Ther
Zhang W, Lan R, Shen T, Qin J, Wang Z, Chen J, Wang J, Wu Z, Xu Y, Shen Y, Lin Q, Chen Y, Wei Y, Liu Y, Ning Y, Zhou Y, Deng L, Han L, Wu X, Deng H, Cao Z, Yao X, Ren X.   +22 more
europepmc   +1 more source

Changes in Pain Sensitization after DMARD therapy are Associated with Changes in Disease Activity in Established Rheumatoid Arthritis

Arthritis &Rheumatology, Accepted Article.
Objective Abnormalities in pain regulatory mechanisms are common in patients with rheumatoid arthritis (RA). We investigated whether pain sensitization changes after treatment with a disease modifying anti‐rheumatic drug (DMARD) and explored associations between changes in pain sensitization and disease activity.
Burcu Aydemir, Andrew C. Heisler, Lutfiyya N. Muhammad, Jing Song, Alyssa Wohlfahrt, Daniel J. Clauw, Wendy Marder, Marcy B. Bolster, Clifton O. Bingham, Tuhina Neogi, Yvonne C. Lee   +10 more
wiley   +1 more source

Paralyzing paradox: Spinal cord infarction, a hidden emergency. [PDF]

Radiol Case Rep
Bhinder KK, Khan KA, Wahla MS, Mehboob A, Shahid A, Ziad A.   +5 more
europepmc   +1 more source

Paracetamol and its metabolites in children and adults with spinal muscular atrophy – a population pharmacokinetic model

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims The aim of the study was to investigate whether differences in paracetamol pharmacokinetics (PK) between spinal muscular atrophy (SMA) patients and healthy controls (HC) could be attributed to specific clinical covariates. Methods Nonlinear mixed‐effects modelling (NONMEM 7.4) was used to develop a population PK model, explore covariates ...
Qiaolin Zhao, Marie Mostue Naume, Brenda C. M. de Winter, Thomas Krag, Sissel Sundell Haslund‐Krog, Karoline Lolk Revsbech, John Vissing, Helle Holst, Morten Hylander Møller, Tessa Munkeboe Hornsyld, Morten Dunø, Christina Engel Hoei‐Hansen, Alfred Peter Born, Per Bo Jensen, Mette Cathrine Ørngreen   +14 more
wiley   +1 more source

Personalized Stem Cell-Based Regeneration in Spinal Cord Injury Care. [PDF]

Int J Mol Sci
Jagadeesan SK, Sandarage RV, Mathiyalagan S, Tsai EC.   +3 more
europepmc   +1 more source

Mitochondria and Endoplasmic Reticulum Contact Site as a Regulator of Proteostatic Stress Responses in Neurodegenerative Diseases

BioEssays, EarlyView.
Recent findings indicate that mitochondria‐associated membranes (MAMs), where the endoplasmic reticulum directly contacts the mitochondria, are a novel microdomain essential for cellular homeostasis, including proteostasis. We summarize the disruption of protein homeostasis and MAM alteration in neurodegenerative diseases, then discuss challenges and ...
Seiji Watanabe, Koji Yamanaka
wiley   +1 more source

Mesenchymal Stem Cells and Their Extracellular Vesicles: Therapeutic Mechanisms for Blood-Spinal Cord Barrier Repair Following Spinal Cord Injury. [PDF]

Int J Mol Sci
Nakazaki M, Yokoyama T, Lankford KL, Hirota R, Kocsis JD, Honmou O.   +5 more
europepmc   +1 more source

A multi-analyte blood test for acute spinal cord injury. [PDF]

J Clin Invest
Azad TD, Ran KR, Materi JD, Raj D, Al-Khindi T, Gabbita S, Li M, Wang ET, Ahmed AK, Parker M, Kalluri AL, Lubelski D, Jackson CM, Sciubba DM, Weingart JD, Bydon A, Witham TF, Nauen DW, Yegnasubramanian S, Theodore N, Bettegowda C.   +20 more
europepmc   +1 more source

Neural electrodes for brain‐computer interface system: From rigid to soft

BMEMat, EarlyView.
Here, we review the development trends of neural electrodes in BCI. This paper highlights the critical role of electrodes in BCI systems, analyzes the limitations of rigid electrodes, and introduces various flexible electrodes. Furthermore, we discuss application scenarios and prospects of BCI electrode technology, aiming to provide valuable references
Dan Yang, Gongwei Tian, Jianhui Chen, Yan Liu, Esha Fatima, Jichuan Qiu, Nik Ahmad Nizam Nik Malek, Dianpeng Qi   +7 more
wiley   +1 more source