Results 91 to 100 of about 189,667 (257)

Dual-directional regulation of spinal cord injury and the gut microbiota

Neural Regeneration Research
There is increasing evidence that the gut microbiota affects the incidence and progression of central nervous system diseases via the brain-gut axis.
Yinjie Cui, Jingyi Liu, Xiao Lei, Shuwen Liu, Haixia Chen, Zhijian Wei, Hongru Li, Yuan Yang, Chenguang Zheng, Zhongzheng Li   +9 more
doaj   +1 more source

Enhancing Maturation of Human Neuromuscular Organoids via Electrical Stimulation

Advanced Science, EarlyView.
A framework for on‐demand and non‐invasive exposure of human neuromuscular organoids (NMOs) to electrical stimuli is established to promote their maturation. The robustness and effectiveness of different stimulation regimes are evaluated via thorough characterization of organoid tissue structure and contraction capacity. Chronic electrical stimulation,
Chrysanthi‐Maria Moysidou, Inês Afonso Martins, Ismail Amr El‐Shimy, Iacopo Bicci, Donatella Cea, Christina Bukas, Isra Mekki, Mara‐Camelia Rusu, Aylin Nebol, Ines Lahmann, Marie Piraud, Enrico Klotzsch, Mina Gouti   +12 more
wiley   +1 more source

Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain

Advanced Science, EarlyView.
Cellular senescence promotes inflammation, tissue degeneration, and chronic back pain. In sparc‐null mice, early oral administration of the senolytic agents o‐vanillin and RG‐7112 reduced senescent cell burden and pro‐inflammatory SASP signaling across intervertebral discs, endplates, vertebral bone, and spinal cord.
Saber Ghazizadeh, Hosni Cherif, Matthew Mannarino, Juiena Sagir, Magali Millecamps, Jean A. Ouellet, Laura S. Stone, Lisbet Haglund   +7 more
wiley   +1 more source

VDAC1 Upregulation Induces Hyperexcitability of Nociceptive Sensory Neurons Via Enhanced Mitochondrial Atp Efflux in Neuropathic Pain

Advanced Science, EarlyView.
The mechanism diagram of VDAC1 mediating neuronal excitability and neuropathic pain. Briefly, VDAC1 is expressed in DRG neurons and is upregulated following CCI‐induced neuropathic pain. This upregulation enhances ATP transport from mitochondria to the cytoplasm in sensory neurons, leading to increased neuronal excitability and pain behavior.
Fengrun Sun, Ning Yu, Liang Yu, Xiaofen Tian, Yujia Ma, Yikuan Xie, Tao Wang, Chao Ma   +7 more
wiley   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair

Advanced Science, EarlyView.
We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing, Yang Yang, Zichen Hong, Chunhui Tian, Huiyu Chu, Susanne Clara Prokop, Hongwei Cai, Mingxia Gu, Jason Tchieu, Ken Mackie, Feng Guo   +10 more
wiley   +1 more source

Engineering Neuronal Network Connectivity Through Precise and Scalable Electrical Modulation

Advanced Science, EarlyView.
This study presents a scalable all‐electrical method for precise neuronal‐circuit reconfiguration based on high‐density microelectrode arrays. By employing biologically inspired plasticity rules, targeted connectivity changes were successfully induced and quantified across diverse neuronal preparations.
Sreedhar S. Kumar, Yannaël Bossard, Rachel Sava, Tobias Gänswein, Lorenca Sadiraj, Jean‐Samuel Dupré, Manuel Schröter, J. Gray Camp, Fernando Cardes, Julian Bartram, Andreas Hierlemann   +10 more
wiley   +1 more source

Veins of Deception: An Intriguing Case of Extradural Spinal AVF Mimicking Longitudinal Extensive Transverse Myelitis

Journal of Clinical Interventional Radiology ISVIR
Longitudinally extensive transverse myelitis (LETM) is a rapidly progressing demyelinating disease affecting the spinal cord over three or more vertebral segments.
Ujjwal Agarwal, Vipul Gupta, Pallav Bhatter, D. S. Rao, Rajsrinivas Parthasarathy   +4 more
doaj   +1 more source

Wavelength‐Dependent Photobiomodulation Regulates Macrophage Polarization via Mitochondrial Dynamics and Metabolic Reprogramming

Advanced Science, EarlyView.
Light wavelength encodes distinct macrophage fates through mitochondrial and metabolic remodeling. Red 625 nm irradiation induces glycolysis, mitochondrial fission, and M1 polarization, whereas near‐infrared 850 nm irradiation promotes fatty acid oxidation, mitochondrial fusion, and M2 polarization.
Qiusheng Shi, Hao Jia, Jianfei Dong, Linhao Li, Jingqi Cao, Xun Chen, Zhenzhen Jia, Jing Na, Zhijie Yang, Xinyuan Chen, Yubo Fan, Shuhua Yue, Lisha Zheng   +12 more
wiley   +1 more source

A new paradigm of bidirectional regulation of the gut–spinal cord axis

Neural Regeneration Research
The bidirectional interactions of spinal cord injury, multiple sclerosis, and amyotrophic lateral sclerosis with the gut operate through a distinct gut–spinal cord axis, rather than being fully explained by the conventional gut–brain axis.
Songzhi Ni, Kai Chen, Haojue Wang, Shenyuan Chen, Yuanyu Qiu, Tianjiao Wang, Fengfeng Mo, Shige Wang, Bo Li, Yushu Bai, Jiulong Zhao, Xiao Zhai, Zhaoshen Li   +12 more
doaj   +1 more source