Results 111 to 120 of about 211,971 (348)

Extracellular LCN2 Binding to 24p3R in Astrocytes Impedes α‐Synuclein Endocytosis in Parkinson's Disease

Advanced Science, EarlyView.
24p3R is an astrocytic receptor for α‐Syn uptake. When LCN2 is secreted from astrocytes, it binds to its receptor 24p3R in astrocytes and this binding impedes the α‐Syn PFF binding to 24p3R. This in turn inhibits 24p3R‐mediated α‐Syn PFF uptake and reduces the clearance of extracellular α‐Syn by astrocytes, which contributes to α‐Syn spread and ...
Ying‐Ying Jiao, Tian Tian, Zhu Zhu, Lei Cao, Yang Liu, Rui‐An Wang, Zhi‐Yong Zhou, Cong Wang, Ke‐Zhong Zhang, Xiao Lu, Wen‐Wei Yun, Ying‐Mei Lu, Gang Hu, Ren‐Hong Du, Ming Lu   +14 more
wiley   +1 more source

Determination of the burden of spinal cord injury and limb amputation as a result of the bam earthquake in 2004

Archives of Trauma Research, 2018
Background and Objectives: This study aimed at investigating the burden of injuries, including spinal cord injuries and limb amputation, caused by the Bam earthquake.
Salman Daneshi, Ali Akbar Haghdoost, Mohamadreza Baneshi, Farzaneh Zolala   +3 more
doaj   +1 more source

Seatbelt use and risk of major injuries sustained by vehicle occupants during motor-vehicle crashes: A systematic review and meta-analysis of cohort studies [PDF]

, 2018
BackgroundIn 2004, a World Health Report on road safety called for enforcement of measures such as seatbelt use, effective at minimizing morbidity and mortality caused by road traffic accidents.
A Akobeng, A Baker, A Renson, A Sen, Abdul-Razak Abubakari, AF Hefny, AK Abbas, Antony R. Morgan, B Fréchède, BT McMullin, C-Y Kuo, CS Crandall, DA Hyman, DC Viano, DF Stroup, DM Stein, F Hillary, F O’Kelly, FM Abu-Zidan, G-M Han, H Yasuoka, J Inamasu, J Inamasu, J IntHout, JK Kuan, JR Funk, JS Cummins, K Dalal, L Evans, Leopold Ndemnge Aminde, M Peden, M-S Lin, MA Bjurlin, MA Reed, N Kulvatunyou, N McGrath, Nicole Fouda Mbarga, O Achildi, OJ Ogundele, P Raychaudhuri, PA Anderson, PM Ho, RD Rao, RH Friis, S Biswas, S Blows, S Wotherspoon, Seat-belts and child restraints, SM Blake, T Sugimoto, TB Dinh-Zarr, V O’Dowd, VM Nantulya, Y Matsui   +53 more
core   +1 more source

A Peripheral Mechanism of Depression: Disturbed Intestinal Epithelial Per2 Gene Expression Causes Depressive Behaviors in Mice with Circadian Rhythm Disruption via Gut Barrier Damage and Microbiota Dysbiosis

Advanced Science, EarlyView.
Circardian rhythm disorder (CRD) causes abnormal expression of intestinal Period 2 (Per2) gene, which compromising intestinal barrier integrity and altering the gut microenvironment. Microbiota dysbiosis and aberrant metabolites production drive central inflammation, impair neurogenesis, and promote functional deficits, ultimately facilitating the ...
Huiliang Zhang, Xuan Qin, Haiyue Song, Jieru Zhou, Hui Wei, Lun Zhang, Yi Liu, Zhuoqun Wang, Yiren Zhang, Yiwen Lai, Jiayu Yang, Wenting Hu, Zhongshan Chen, Ji Zeng, Yu Jin, Xiaochuan Wang, Rong Liu   +16 more
wiley   +1 more source

DIFFERENT TYPES OF INSPIRATORY MUSCLE TRAINING PROVIDES BETTERMENT IN ALTERED PULMONARY FUNCTIONS IN UPPER THORACIC SPINAL CORD INJURIES

International Journal of Physiotherapy, 2016
Background: Respiratory problems are usual in upper thoracic spinal cord injuries when compared to Lower thoracic spinal cord injuries. Generally there are frequent respiratory complications in the individuals with spinal cord injuries. The complications
Muruganandam Periyasamy, Paul Chandanshive, Pasupuleti Visweswara Rao   +2 more
doaj   +1 more source

Is the vagus nerve our neural connectome? [PDF]

, 2018
What are the implications of the vagus nerve being able to mediate the time-dependent plasticity of an array of sensorimotor ...
Alvarez-Dieppa, De Ridder, Edelman, Gad, Ganzer, Hays, He, Hulsey   +7 more
core   +1 more source

Potentiating Cerebral Perfusion Normalizes Glymphatic Dynamics in Systemic Inflammation

Advanced Science, EarlyView.
LPS‐induced systemic inflammation increases glymphatic influx but delays cervical lymphatic drainage, accompanied by AQP4 depolarization and impaired glymphatic clearance. Enhancing cerebral blood flow via the inotropic agent levosimendan effectively restored AQP4 polarization, improving glymphatic flux and amyloid‐β clearance.
Ruoyu Zhao, Bin Sun, Pengju Wei, Yingying Sun, Qianyan He, Kejia Zhang, Jun Lu, Shoujun Zhu, Yi Yang, Zhenni Guo   +9 more
wiley   +1 more source

Neurophysiological, histological, and behavioral characterization of animal models of distraction spinal cord injury: a systematic review

Neural Regeneration Research
Distraction spinal cord injury is caused by some degree of distraction or longitudinal tension on the spinal cord and commonly occurs in patients who undergo corrective operation for severe spinal deformity.
Bo Han, Weishi Liang, Yong Hai, Duan Sun, Hongtao Ding, Yihan Yang, Peng Yin   +6 more
doaj   +1 more source

The Distribution of Paralysis and Anaesthesia in Injuries of the Cervical Region of the Spinal Cord [PDF]

, 1888
William Thorburn
openalex   +1 more source