Results 111 to 120 of about 158,895 (307)

TEAD1 Enhances Exosome Secretion and Promotes Exosome‐Mediated Tissue Regeneration

Advanced Science, EarlyView.
TEAD1 functions as a crucial molecular switch regulating exosome secretion in various cell types. TEAD1 enhances exosome secretion by upregulating key proteins associated with exosome secretion, including RAB11, CD9, and SNAP23. This study reveals a novel role for TEAD1 in regulating exosome secretion and tissue regeneration, particularly in diabetic ...
Yan Pu, Yi Wan, Wenhao Shi, Bin Li, Haiyue Zhang, Jun Wu, Lingling Li, Wenjia Guo, Chen Ding, Wenjun Yang   +9 more
wiley   +1 more source

SAME-LEVEL FALLS IN OLDER ADULTS: FACTORS ASSOCIATED WITH TRAUMATIC BRAIN AND SPINAL CORD INJURIES

Cogitare Enfermagem, 2018
Objective: to identify factors associated with the occurrence of traumatic brain and spinal cord injuries among older adults who suffered a same-level fall.
Josy Anne Silva, Gustavo Henrique Marques Moreno, Liliana Yukie Hayakawa, Kelly Cristina Inoue, Roberto Kenji Nakamura Cuman   +4 more
doaj   +1 more source

The Role of Ionic Liquids at the Biological Interfaces in Bioelectronics

Advanced Science, EarlyView.
Ionic liquids (ILs) are highlighted as key artificial ionic materials that bridge biological ion‐based signaling and electronic devices. By understanding their composition, structure, function relationships, and mechanisms, ILs can advance from high performance electrolyte to core materials enabling integrated, multifunctional bioelectronics for ...
Yeong‐sinn Ye, Young Jin Jo, Ji Yeon Oh, Ju Yeon Jeong, Lili Guo, Tae‐il Kim   +5 more
wiley   +1 more source

Exploring synthetic controls in rare diseases with a proof of concept in spinal cord injury

BMC Medicine
Background Successfully completing clinical trials for rare and heterogeneous disorders, like spinal cord injuries (SCI), remains challenging, thereby reducing the ability to test and translate promising preclinical findings.
Louis P. Lukas, Samuel Håkansson, Miklovana Tuci, Abel Torres-Espín, Rüdiger Rupp, Olga Taran, Norbert Weidner, Fred Geisler, Martin Schubert, Frank Röhrich, Yorck B. Kalke, Rainer Abel, Doris Maier, Harvinder S. Chhabra, Thomas Liebscher, EMSCI study group, John L. K. Kramer, Marc Bolliger, Armin Curt, Catherine R. Jutzeler, Sarah C. Brüningk   +20 more
doaj   +1 more source

Determination of the burden of spinal cord injury and limb amputation as a result of the bam earthquake in 2004

Archives of Trauma Research, 2018
Background and Objectives: This study aimed at investigating the burden of injuries, including spinal cord injuries and limb amputation, caused by the Bam earthquake.
Salman Daneshi, Ali Akbar Haghdoost, Mohamadreza Baneshi, Farzaneh Zolala   +3 more
doaj   +1 more source

Deciphering and Targeting the Schwannoma‐Neuron‐Macrophage Crosstalk for the Treatment of Schwannomatosis and Associated Pain

Advanced Science, EarlyView.
We established patient‐derived SWN cell lines and orthotopic PDX models that recapitulate patient pain phenotypes, alongside a novel intravital DRG imaging platform to track macrophage infiltration and neuronal pain responses. Using these models, we define HMGB1–CCL2–IL‐6 signaling crosstalk driving pain and identify EGF signaling as a key regulator of
Zhenzhen Yin, Limeng Wu, Yanling Zhang, Yao Sun, Grace Y. Lee, Simeng Lu, Xing Gao, John W. Chen, Sonu Subudhi, William Ho, Chao Zhu, Jun Ren, Gino B. Ferraro, Alona Muzikansky, Anat Stemmer‐Rachamimov, Jianren Mao, Scott R. Plotkin, Lei Xu   +17 more
wiley   +1 more source

Neurophysiological, histological, and behavioral characterization of animal models of distraction spinal cord injury: a systematic review

Neural Regeneration Research
Distraction spinal cord injury is caused by some degree of distraction or longitudinal tension on the spinal cord and commonly occurs in patients who undergo corrective operation for severe spinal deformity.
Bo Han, Weishi Liang, Yong Hai, Duan Sun, Hongtao Ding, Yihan Yang, Peng Yin   +6 more
doaj   +1 more source

A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia

Advanced Science, EarlyView.
A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun, Jia‐Jia Wang, Xiang‐Yu Li, Xin‐Yi Lin, Juan Li, Qiu‐Tong Yu, Zi‐Han Wang, Xue‐Ping Gao, Lei Jin, Wei‐Ke Li, Tian‐Lin Cheng, Juan Deng   +11 more
wiley   +1 more source

Cervicomedullary Spinal Cord Injury

Journal of Orthopaedic Case Reports
Introduction: Spinal cord injury (SCI) is most common following trauma, typically involving motor vehicle incidents. The clinical prognosis depends on many factors, most importantly the initial grade of injury. Case Report: We present a 26-year-old male who presents to the emergency department after a motor vehicle accident.
Noah King, Andrew Waack, Ethan Kosco, Aastha Bhavsar, Jason Schroeder, Alastair Hoyt   +5 more
openaire   +3 more sources