Results 111 to 120 of about 868,535 (300)

Magnetically Actuated Microrobot for Drug Delivery: Current Progress and Challenges

Advanced Robotics Research, EarlyView.
Magnetically actuated microrobots are reshaping targeted drug delivery through wireless propulsion, programmable materials, and localized therapeutic release. This review examines how fabrication, body material selection, structural architecture, loading mechanisms, and imaging‐guided control converge to enable microrobotic therapies while identifying ...
Yang Yang, David J. Cappelleri
wiley   +1 more source

Criteria codes for unrecognized stroke/TIA patients by Emergency Medical Services dispatchers in Copenhagen, Denmark

BMC Emergency Medicine
Background Early diagnosis is essential in stroke treatment. Medical dispatchers play a key role in ensuring quick assessment, transport, and treatment of stroke patients by recognizing stroke symptoms.
Philip Busch Andreasen, Jonathan Wenstrup, Stig Nikolaj Fasmer Blomberg, Christina Kruuse, Helle Collatz Christensen   +4 more
doaj   +1 more source

Management of spinal injuries in a patient with polytrauma

Journal of Orthopedics, Traumatology and Rehabilitation, 2013
Acute spinal cord injury primarily affects young otherwise healthy people and is a major cause of patient morbidity and a source of significant health care expenditure.
Roop Bhushan Kalia, Alok Chandra Agrawal
doaj   +1 more source

Mesenchymal stem cell grafts promote oligodendroglial differentiation after spinal cord injury [PDF]

, 2012
Transplantation of MSC into the acute injured spinal cord is sufficient to enhance oligodendroglial differentiation of endogenous spinal cord progenitor cells up to one month post-injury.
Bründl, Johannes
core   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

Co‐Delivery of Sustained Release Chondroitinase ABC‐37 With Human iPSC‐Derived Neural Progenitors Promotes Transplant Survival and Functional Recovery in a Rodent Model of Stroke

Advanced Science, EarlyView.
A regenerative strategy for stroke combines human stem cell–derived neural progenitor cells with sustained release of a matrix‐modifying, thermostable chondroitinase ABC‐37 enzyme. In a rat model of stroke, co‐delivery enhanced transplanted cell survival and neuronal differentiation, degraded inhibitory extracellular matrix components, and improved ...
Nitzan Letko Khait, David Xinzheyang Li, Keyi Guo, Hong Cui, Quinton Sirianni, Dhana Abdo, Cindi M. Morshead, Molly S. Shoichet   +7 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Exploring synthetic controls in rare diseases with a proof of concept in spinal cord injury

BMC Medicine
Background Successfully completing clinical trials for rare and heterogeneous disorders, like spinal cord injuries (SCI), remains challenging, thereby reducing the ability to test and translate promising preclinical findings.
Louis P. Lukas, Samuel Håkansson, Miklovana Tuci, Abel Torres-Espín, Rüdiger Rupp, Olga Taran, Norbert Weidner, Fred Geisler, Martin Schubert, Frank Röhrich, Yorck B. Kalke, Rainer Abel, Doris Maier, Harvinder S. Chhabra, Thomas Liebscher, EMSCI study group, John L. K. Kramer, Marc Bolliger, Armin Curt, Catherine R. Jutzeler, Sarah C. Brüningk   +20 more
doaj   +1 more source

SAME-LEVEL FALLS IN OLDER ADULTS: FACTORS ASSOCIATED WITH TRAUMATIC BRAIN AND SPINAL CORD INJURIES

Cogitare Enfermagem, 2018
Objective: to identify factors associated with the occurrence of traumatic brain and spinal cord injuries among older adults who suffered a same-level fall.
Josy Anne Silva, Gustavo Henrique Marques Moreno, Liliana Yukie Hayakawa, Kelly Cristina Inoue, Roberto Kenji Nakamura Cuman   +4 more
doaj   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source