Results 171 to 180 of about 515,416 (354)

Disrupting CSPG‐Driven Microglia–Astrocyte Crosstalk Enables Scar‐Free Repair in Spinal Cord Injury

Advanced Science, EarlyView.
This study identifies CSPGs as key drivers of glial scar maturation after spinal cord injury by reprogramming microglial metabolism and inducing astrocyte fibrosis. To address this, a reactive oxygen species‐responsive, reactive astrocyte‐targeted ChABC gene delivery system is designed to locally degrade CSPGs, precisely disrupt maladaptive glial ...
Yufei Zheng, Zhaowei Zhang, Zezhou Fu, Qingqing Wang, Siwen Zhang, Tingyu Zhang, Meifei Zhu, Shunwu Fan, Youqing Shen, Jiajia Xiang, Xin Liu   +10 more
wiley   +1 more source

Clinical Reasoning: Patient With Prior Spinal Cord Injury Who Developed Altered Mental Status After a Fall [PDF]

, 2022
Alexa Dessy, Dhristie Bhagat, Barry Czeisler   +2 more
openalex   +1 more source

CRISPLD2 Attenuates Intervertebral Disc Degeneration by Suppressing Oxidative Stress‐Induced Ferroptosis through the miR‐548I‐IL17A Axis

Advanced Science, EarlyView.
This study identifies CRISPLD2 as a key protector against IVDD. By regulating ferroptosis through the CRISPLD2–miR‐548I–IL17A axis, CRISPLD2 maintains NPCs homeostasis and reduces oxidative stress. Restoring CRISPLD2 expression effectively alleviates disc degeneration and highlights a promising therapeutic strategy for discogenic low back pain ...
Yangyang Shi, Fudong Li, Tianyi Zhao, Kaiqiang Sun, Danying Zhang, Chen Yan, Ximing Xu, Jingchuang Sun, Xulin Hu, Xin Yong, Jiangang Shi, Yuan Wang   +11 more
wiley   +1 more source

Large-scale reorganization of the somatosensory cortex following spinal cord injuries is due to brainstem plasticity

Nature Communications, 2014
Niranjan A. Kambi, Priyabrata Halder, Radhika Rajan, V. Arora, P. Chand, Manika Arora, N. Jain   +6 more
semanticscholar   +1 more source

Crossing the Blood–Brain Barrier with Molecularly Imprinted Polymeric Nanocarriers: An Emerging Frontier in Brain Disease Therapy

Advanced Science, EarlyView.
Molecularly imprinted polymeric nanocarriers (nanoMIPs) offer robust, antibody‐mimetic platforms to overcome the blood‐brain barrier. The article surveys nanoMIP design and ligand‐directed surface engineering that harness receptor‐mediated transcytosis, and highlights therapeutic and diagnostic applications in neurodegeneration, brain tumors and ...
Ranjit De, Shuliang Shi, Kyong‐Tai Kim
wiley   +1 more source

Facilitators and barriers in the rehabilitation process described by persons with spinal cord injury: a deductive-inductive analysis from the Finnish spinal cord injury study

, 2023
Susanna Tallqvist, Kaarina Eskola, Anni Täckman, Anna-Maija Kauppila, Eerika Koskinen, Heidi Anttila, Marketta Rajavaara, Jari Arokoski, Sinikka Hiekkala   +8 more
openalex   +1 more source

RPS3‐Enriched Extracellular Vesicles Mediate Liver‐Spinal Cord Inter‐Organ Communication

Advanced Science, EarlyView.
Spinal cord injury activates the liver to send extracellular vesicles loaded with RPS3 protein to the lesion site. These vesicles are taken up by neural stem cells and astrocytes, triggering NF‐κB signaling, impairing the regeneration of neurons and myelin, and promotes harmful inflammation, ultimately hindering recovery.
Peiwen Song, Zuomeng Wu, Yixiang Dong, Yunxiong Fang, Shiyu Bian, Daokuan Wang, Huang Fang, Yunlei Liu, Wang Ying, Jun Qian, Tianyu Han, Cailiang Shen   +11 more
wiley   +1 more source

MicroRNA‑138‑5p regulates the development of spinal cord injury by targeting SIRT1

, 2020
Jinchuan Chen, Rujie Qin
openalex   +2 more sources

Spinal Cord Injury Research Program Clinical Trial Award (DOD) [PDF]

, 2023

openalex   +1 more source

Traumatic versus non-traumatic spinal cord injuries: are there differential rehabilitation outcomes?

Spinal Cord, 2013
P. Kennedy, Z. Chessell
semanticscholar   +1 more source