Results 181 to 190 of about 514,376 (398)

Large-scale reorganization of the somatosensory cortex following spinal cord injuries is due to brainstem plasticity

Nature Communications, 2014
Niranjan A. Kambi, Priyabrata Halder, Radhika Rajan, V. Arora, P. Chand, Manika Arora, N. Jain   +6 more
semanticscholar   +1 more source

Synovial Fluid‐derived Micrococcus Luteus G18 Exacerbates Osteoarthritis Progression by Promoting Chondrocyte Degradation via TLR2/JNK/AP‐1 Signaling Pathway

Advanced Science, EarlyView.
Traditionally considered sterile, the articular cavity is now recognized to harbor microbial communities influencing osteoarthritis (OA). Integrating 16S rRNA sequencing and culturomics, Micrococcus luteus is enriched in advanced OA. Notably, M. luteus G18 exacerbates cartilage degeneration via TLR2/JNK/AP‐1‐mediated ECM disruption, revealing intra ...
Tingtao Chen, Qingwei Zeng, Tangchang Xu, Xinyue Qi, Kaiyi Li, Jing Wei, Liang Hao   +6 more
wiley   +1 more source

Therapeutic Potential of Olfactory Ensheathing Cells and Mesenchymal Stem Cells in Spinal Cord Injuries [PDF]

, 2017
Anna Zadroga, Katarzyna Jezierska‐Woźniak, Joanna Czarzasta, Monika Barczewska, Joanna Wojtkiewicz, Wojciech Maksymowicz   +5 more
openalex   +1 more source

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

Advanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu, Yunmin Zhu, Xi Wang, Zelin Wu, Zijian Xu, Rongqing Chen, Yanwu Guo   +6 more
wiley   +1 more source

Bone marrow mesenchymal stem cells stimulated with low‐intensity pulsed ultrasound: Better choice of transplantation treatment for spinal cord injury [PDF]

, 2018
Guangzhi Ning, Wenye Song, Hong Xu, Rusen Zhu, Qiuli Wu, Yu Wu, Shibo Zhu, Ji‐Qing Li, Man Wang, Zhigang Qu, Shiqing Feng   +10 more
openalex   +1 more source

A Sensitive and Fast Fiber Bragg Grating-Based Investigation of the Biomechanical Dynamics of In Vitro Spinal Cord Injuries [PDF]

, 2021
Satyendra K. Mishra, Jean‐Marc Mac‐Thiong, Éric Wagnac, Yvan Petit, Bora Ung   +4 more
openalex   +1 more source

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

A Data-Globe and Immersive Virtual Reality Environment for Upper Limb Rehabilitation after Spinal Cord Injury

, 2013
Ana de los Reyes-Guzmán, Iris Dimbwadyo-Terrer, Fernando Trincado-Alonso, Miguel A. Aznar, Cesar Alcubilla, Soraya Pérez‐Nombela, Antonio J. del‐Ama, Begoña Polonio López, Ángel Gil-Agudo   +8 more
openalex   +2 more sources

Traumatic versus non-traumatic spinal cord injuries: are there differential rehabilitation outcomes?

Spinal Cord, 2013
P. Kennedy, Z. Chessell
semanticscholar   +1 more source

Disrupting CSPG‐Driven Microglia–Astrocyte Crosstalk Enables Scar‐Free Repair in Spinal Cord Injury

Advanced Science, EarlyView.
This study identifies CSPGs as key drivers of glial scar maturation after spinal cord injury by reprogramming microglial metabolism and inducing astrocyte fibrosis. To address this, a reactive oxygen species‐responsive, reactive astrocyte‐targeted ChABC gene delivery system is designed to locally degrade CSPGs, precisely disrupt maladaptive glial ...
Yufei Zheng, Zhaowei Zhang, Zezhou Fu, Qingqing Wang, Siwen Zhang, Tingyu Zhang, Meifei Zhu, Shunwu Fan, Youqing Shen, Jiajia Xiang, Xin Liu   +10 more
wiley   +1 more source