Results 211 to 220 of about 193,351 (379)

Cryopreservation practices in clinical and preclinical iPSC‐based cell therapies: Current challenges and future directions

open access: yesBiotechnology Progress, EarlyView.
Abstract Induced pluripotent stem cells (iPSCs) offer significant therapeutic potential, but cryopreservation challenges, particularly the reliance on cytotoxic Dimethyl Sulfoxide (Me2SO), hinder their clinical application. This review examines current cryopreservation practices in clinical and preclinical iPSC‐based therapies, highlighting the ...
Michael Dobruskin   +2 more
wiley   +1 more source

Nerve growth factor receptors in equine synovial membranes vary with osteoarthritic disease severity

open access: yesJournal of Orthopaedic Research, Volume 41, Issue 2, Page 316-324, February 2023., 2023
Abstract Nerve growth factor (NGF) is a neurotrophin that has been implicated in pain signaling, apoptosis, inflammation and proliferation. The resultant effects depend on interaction with two different receptors; tyrosine kinase A (TrkA) and p75NTR. NGF increases in synovial fluid from osteoarthritic joints, and monoclonal antibody therapy is trialed ...
Anna Kendall   +2 more
wiley   +1 more source

Copper in cancer: friend or foe? Metabolism, dysregulation, and therapeutic opportunities

open access: yesCancer Communications, EarlyView.
Abstract Copper, one of the essential nutrients for the human body, acts as an electron relay in multiple pathways due to its redox properties. Both deficiencies and excesses of copper lead to cellular fragility. Therefore, it can manifest pro‐ and anti‐cancer properties in tumors. Therefore, it is crucial to clarify the copper activity within the cell.
Dan Shan   +13 more
wiley   +1 more source

Implementation of a best‐practice guideline: Early enteral nutrition in a neuroscience intensive care unit

open access: yesJournal of Parenteral and Enteral Nutrition, Volume 47, Issue 1, Page 87-91, January 2023., 2023
Abstract Current evidence suggests that early enteral nutrition is a best practice and leads to improved clinical outcomes. An evidence‐based practice project was implemented in a busy neurointensive care unit in a midwestern tertiary care facility that was designed to improve care by implementing the early nutrition portion of Guidelines for the ...
Sunshine Barhorst   +2 more
wiley   +1 more source

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