Results 191 to 200 of about 732,175 (355)

Expression of Neuronal Nitric Oxide Synthase (nNOS) on Ischemia/reperfusion Injury in Rat Spinal Cord [PDF]

open access: bronze, 2007
Hee Uk Kwon   +6 more
openalex   +1 more source

Synovial Fluid‐derived Micrococcus Luteus G18 Exacerbates Osteoarthritis Progression by Promoting Chondrocyte Degradation via TLR2/JNK/AP‐1 Signaling Pathway

open access: yesAdvanced Science, EarlyView.
Traditionally considered sterile, the articular cavity is now recognized to harbor microbial communities influencing osteoarthritis (OA). Integrating 16S rRNA sequencing and culturomics, Micrococcus luteus is enriched in advanced OA. Notably, M. luteus G18 exacerbates cartilage degeneration via TLR2/JNK/AP‐1‐mediated ECM disruption, revealing intra ...
Tingtao Chen   +6 more
wiley   +1 more source

Targeted delivery of the GPX4 activator via HUCMSC-derived exosomes inhibits ferroptosis in spinal cord injury

open access: yesJournal of Nanobiotechnology
Spinal cord injury (SCI) is a severe and multifaceted neurological trauma characterized by neuronal loss, axonal disruption, and limited regenerative potential, often causing lasting neurological deficits. Ferroptosis promotes neural cell death following
Baoyou Fan   +18 more
doaj   +1 more source

Key genes expressed in different stages of spinal cord ischemia/reperfusion injury

open access: gold, 2016
Tingting Hou   +8 more
openalex   +1 more source

Nanomedicines Against Mitochondrial Dysfunction‐Induced Metabolic Diseases

open access: yesAdvanced Science, EarlyView.
Mitochondrial dysfunction is central to metabolic diseases. Nanomedicine offers transformative approaches for restoring function via targeted delivery, responsive release, and multimodal therapy. This review outlines the pathological basis, nanocarrier design, organelle‐specific targeting, recent advances, and future clinical translation challenges ...
Ke Xu   +9 more
wiley   +1 more source

Gold Nanoturf‐Mediated Wireless Photothermal Upregulation of Human Adipose‐Derived Stem Cell Spheroids for Synergistic Skin‐Wound Closure

open access: yesAdvanced Science, EarlyView.
A wireless skin‐wound care platform for photothermal‐stem cell‐light (PTSCL) therapy, introduced here, leverages a fully wireless and battery‐free optoelectronic module, gold nanoturf‐mediated photothermal interface, and human adipose‐derived stem cell (hADSC) spheroids to synergistically enhance wound healing.
Jong Uk Kim   +17 more
wiley   +1 more source

Functional Outcome of Neurologic-Controlled HAL-Exoskeletal Neurorehabilitation in Chronic Spinal Cord Injury: A Pilot With One Year Treatment and Variable Treatment Frequency

open access: gold, 2017
Oliver Jansen   +8 more
openalex   +1 more source

Disrupting CSPG‐Driven Microglia–Astrocyte Crosstalk Enables Scar‐Free Repair in Spinal Cord Injury

open access: yesAdvanced Science, EarlyView.
This study identifies CSPGs as key drivers of glial scar maturation after spinal cord injury by reprogramming microglial metabolism and inducing astrocyte fibrosis. To address this, a reactive oxygen species‐responsive, reactive astrocyte‐targeted ChABC gene delivery system is designed to locally degrade CSPGs, precisely disrupt maladaptive glial ...
Yufei Zheng   +10 more
wiley   +1 more source

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