Results 91 to 100 of about 46,554 (341)

Spinal Cord Malformation Containing a Papillary Neoplasm

The FASEB Journal, 2008
A 36‐year‐old man had lower back pain for over one year. MRI revealed an intradural mass with a cystic component, inferior to the spinal cord at L2‐L3, with no bony abnormality of the spine. At surgery, the mass was entirely intradural, inferior to the spinal cord and intimately attached to nerve roots of the cauda equina.
Leroy R. Sharer, Robert F. Heary, Eun‐Sook Cho, Douglas C. Miller   +3 more
openaire   +1 more source

An Implantable Scaffold Sequentially Releasing STING Agonist and B7‐H3 Antibody for Bone Metastasis Immunotherapy

Advanced Science, EarlyView.
We developed an implantable dual‐drug depot using GelMA for bone metastasis treatment, co‐delivering MSA‐2 and αB7‐H3‐loaded CaCO3 microparticles. Sustained release from GelMA scaffold enables MSA‐2 to activate STING signaling and enhance T‐cell infiltration and activation, while sequentially released αB7‐H3 blocks MSA‐2‐induced B7‐H3 upregulation ...
Qijun Lin, Hong Xiao, Shuai Fan, Kaimin Cai, Yanteng Xu, Xinwen Wang, Guanhong Chen, Chuandong Lang, Xinsheng Peng, Mingqiang Li, Yuhu Dai   +10 more
wiley   +1 more source

Clinical characteristics and molecular mechanisms underlying bladder cancer in individuals with spinal cord injury: a systematic review

BMC Urology
Background Patients with spinal cord injury have a relatively high risk for bladder cancer and often complicated with bladder cancer in advanced stages, and the degree of aggressiveness of malignancy is high.
Xin-Lei Wang, Yi-Xuan Wang, Jun-Zhi Chen, Xin-Yu Liu, Xing Liu, Qi-Kai Zhong, Zi-Lin Zhao, Zhen-Duo Shi, Cong-Hui Han   +8 more
doaj   +1 more source

Multiple sclerosis and syringomyelia – a case report

Aktualności Neurologiczne, 2019
Syringomyelia is associated with more than two-thirds of Chiari malformation type I cases, and rarely with intramedullary neoplasm or post-traumatic cavitations.
Katarzyna Kapica-Topczewska, Joanna Tarasiuk, Piotr Szydlik, Eugeniusz Tarasow, Jan Kochanowicz, Alina Kułakowska   +5 more
doaj   +1 more source

Fully Humanized Bispecific T Cell Engager Shows Potent Activity in Central Nervous System and Peripheral Tumors

Advanced Science, EarlyView.
This study reports the development of a fully humanized bispecific T cell engager targeting IL13RA2, a tumor‐associated antigen enriched in glioblastoma. This off‐the‐shelf immunotherapy drives potent, antigen‐dependent T cell activation and tumor killing, and prolongs survival in experimental GBM and other solid tumors models without detectable off ...
Joseph T. Duffy, Angela Martin‐Regalado, Benedikt E. Haupt, Jacob R. Pogue, Aditi Thakur, Manuel Fierro Cota, Markella Zannikou, Sol Misener, Vera P. Krymskaya, Kathleen McCortney, Jason Miska, Craig Horbinski, Dmitri Simberg, Maciej S. Lesniak, Charles D. James, Roger Stupp, Irina V. Balyasnikova   +16 more
wiley   +1 more source

Microscopy with ultraviolet surface excitation for rapid slide-free histology. [PDF]

, 2017
Histologic examination of tissues is central to the diagnosis and management of neoplasms and many other diseases, and is a foundational technique for preclinical and basic research.
Bishop, John, Borowsky, Alexander D, Demos, Stavros G, Fereidouni, Farzad, Harmany, Zachary T, Kintner, John A, Lechpammer, Mirna, Levenson, Richard, McPherson, John D, Tian, Miao, Todd, Austin   +10 more
core   +2 more sources

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Cervical Intramedullary Ganglioma [PDF]

, 2008
A 48 year male presented to the ER with severe headaches which were episodic in nature and which had been present for several weeks. Patient had a history of traumatic head injury (TBI) several years prior.
Ratliff MD, John K., Sharan MD, Ashwini, Singh MD, Harminder   +2 more
core   +1 more source

Cellular deconvolution of GTEx tissues powers discovery of disease and cell-type associated regulatory variants. [PDF]

, 2020
The Genotype-Tissue Expression (GTEx) resource has provided insights into the regulatory impact of genetic variation on gene expression across human tissues; however, thus far has not considered how variation acts at the resolution of the different cell ...
D'Antonio, Matteo, D'Antonio-Chronowska, Agnieszka, Donovan, Margaret KR, Frazer, Kelly A   +3 more
core  

Rudimentary meningocele: remnant of a neural tube defect? [PDF]

, 2001
Background: Rudimentary meningocele, a malformation in which meningothelial elements are present in the skin and subcutaneous tissue, has been described in the past, under a variety of different terms and has also been referred to as cutaneous meningioma.
El Shabrawi-Caelen, Laila, Frieden, Ilona J., Kim, Bang-Soon, McCalmont, Timothy H., Soyer, Hans Peter, White, Wain L.   +5 more
core   +1 more source