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Toxicologic Pathology Forum Opinion: Interpretation of Gliosis in the Brain and Spinal Cord Observed During Nonclinical Safety Studies

Toxicologic pathology (Print), 2023
Gliosis, defined as a nonneoplastic reaction (hypertrophy and/or proliferation) of astrocytes and/or microglial cells, is a frequent finding in the central nervous system (CNS [brain and/or spinal cord]) in nonclinical safety studies.
B. Bolon
semanticscholar   +1 more source

Part I: Spinal-cord neoplasms—intradural neoplasms

The Lancet Oncology, 2007
Intradural spinal-cord tumours are an uncommon but important consideration in the differential diagnosis of patients with back pain, radicular pain, sensorimotor deficits, or sphincter dysfunction. Intradural spinal tumours can be divided into intramedullary and extramedullary spinal-cord tumours on the basis of their anatomical relation to the spinal ...
David E, Traul   +2 more
openaire   +2 more sources

[Spinal deformations as a cause for the clinical signs of spinal cord neoplasm].

open access: closedZhurnal voprosy neirokhirurgii imeni N. N. Burdenko, 2003
An attempt was made to explain the unusual clinical manifestations at the example of an observation of a spinal-marrow tumor, which had the neurological lesion symptoms only below the upper-thoracic level. Scoliosis with a minor spinal deformation at the level of the fourth thoracic vertebra was a tumor symptom.
El'ner Am
openaire   +2 more sources

Intramedullary Spinal Cord Malakoplakia Mimicking Malignant Neoplasm on 18F-FDG PET/CT

open access: closedClinical Nuclear Medicine
We report a rare case of intramedullary spinal cord malakoplakia mimicking malignancy on 18F-FDG PET/CT. A 61-year-old man underwent a contrast-enhanced spinal cord MRI to evaluate 1 week of progressive left-sided weakness.
Woo Jung Sung, Byung Wook Choi
openalex   +2 more sources

Recurrent solitary fibrous tumor of the spinal cord: A case report and literature review.

Clinical Neuropathology, 2020
Solitary fibrous tumor (SFT) is a benign mesenchymal neoplasm occurring anywhere in the body, such as the visceral pleura, while it is extremely rare in the central nervous system, especially within the spinal cord.
Yinggao Chen   +3 more
semanticscholar   +1 more source

NEOPLASMS OF THE SPINAL CORD

Journal of the American Medical Association, 1936
There are but few organs in the human body in which neoplastic disease occurs in a more benign form and the results of surgery are more brilliant than in the spinal cord and its membranes. At the same time there is no organ in which total restoration of function following the removal of the neoplasm is so completely dependent on an early diagnosis ...
openaire   +1 more source

Spinal Cord Neoplasms

2010
Spinal cord neoplasms are an uncommon cause of back pain, radicular pain, or sensorymotor defi cits. Primary tumors that involve the spinal cord or nerve roots may arise from glial cells located within the parenchyma of the cord, Schwann cells of the nerve roots, or meningeal cells covering the cord.
Luca Denaro, Domenico D'Avella
openaire   +1 more source

Experimental spinal cord compression by epidural neoplasms

Neurology, 1977
We have developed an experimental model of spinal cord compression in rats. Tumor injected anterior to the T-12 vertebral body grows through the intervertebral foramina to compress the cord and produces paraplegia in 3 to 4 weeks. Evidence for vasogenic edema in spinal cord compressed by tumor includes increased water content, leakage of horseradish ...
Y, Ushio   +3 more
openaire   +2 more sources

FDG PET/CT and MRI in Primary Spinal Cord Glioblastoma.

Clinical Nuclear Medicine, 2019
Glioblastoma is the most common primary malignant tumor of the central nervous system, most of which occur in the brain. Primary spinal cord glioblastoma is extremely rare.
G. Shen   +4 more
semanticscholar   +1 more source

Spinal Cord Neoplasms

Continuum
This article discusses the diagnostic approach to patients with suspected neoplasms of the spinal cord and reviews the most common primary and metastatic spinal neoplasms and their presentations.Neoplasms of the spinal cord are rare entities that can involve the spinal cord parenchyma, the dura and leptomeninges, or the extradural space.
openaire   +2 more sources

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