Results 151 to 160 of about 54,339 (259)

Novel approaches for drug development against chronic primary pain: A systematic review

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus   +5 more
wiley   +1 more source

Preoperative Embolization of a Spinal Metastasis With Obsidio Conformable Embolic: A Case Report. [PDF]

open access: yesStroke Vasc Interv Neurol
Higginbotham A   +7 more
europepmc   +1 more source

Cancer pain: current practice and emerging targets

open access: yesBritish Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye   +5 more
wiley   +1 more source

Frailty and Fitness in Older Adults With Acute Myeloid Leukemia: From Chronological Age to Multiparametric Assessment

open access: yesEuropean Journal of Haematology, EarlyView.
ABSTRACT Acute Myeloid Leukemia predominantly affects older adults, who often present with comorbidities, functional impairment, and frailty, limiting eligibility for intensive chemotherapy or allogeneic transplantation. Historically, treatment options were restricted to hypomethylating agents, low‐dose cytarabine, hydroxyurea, or supportive care, with
Antonella Bruzzese   +11 more
wiley   +1 more source

Extradural spinal neurocysticercosis mimicking epidural abscess: a case report. [PDF]

open access: yesAnn Med Surg (Lond)
Lamichhane S   +6 more
europepmc   +1 more source

Surgical removal of a perirectal melanoma through sphincterotomy and rectal wall resection in a horse

open access: yesEquine Veterinary Education, EarlyView.
Summary Melanomas are among the most frequent neoplasms in grey horses. Deep perirectal melanomas, however, are uncommon and challenging to excise due to their proximity to the peritoneal reflection. This report describes the successful standing removal of a large (16 × 8 × 6 cm) perirectal melanoma firmly adherent to the dorsal rectal wall in a 19 ...
R. Becker, C. Koch, M. de Preux
wiley   +1 more source

Unilateral biportal endoscopy for thoracic intradural meningioma: a two-case technical report and narrative discussion. [PDF]

open access: yesJ Spine Surg
Castillo Rangel C   +7 more
europepmc   +1 more source

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