Results 121 to 130 of about 506,543 (349)

Exciting innovations for the spinally injured [PDF]

, 2002
Spinal injury can be devastating, resulting, as it often does, in some paralysis and loss of sensation. Engineering plays an important role in spinal cord injury rehabilitation.
Hunt, K.J., McLean, A.N.
core  

Optogenetic Interrogation of Functional Synapse Formation by Corticospinal Tract Axons in the Injured Spinal Cord [PDF]

, 2016
To restore function after injury to the CNS, axons must be stimulated to extend into denervated territory and, critically, must form functional synapses with appropriate targets. We showed previously that forced overexpression of the transcription factor
Balle, Eric, Blackmore, Murray G., Hoeynck, Brian, Jayaprakash, Naveen, Kramer, Audra A., Krueger, Nicholas, Wang, Zimei, Wheeler, Daniel S., Wheeler, Robert A.   +8 more
core   +2 more sources

Pharmacological Microglial Inhibition Remodels the Scar Microenvironment to Support Reticulospinal Circuit Reconstruction After Spinal Cord Injury

Advanced Science, EarlyView.
This study establishes pharmacological microglial inhibition as a therapeutic strategy, demonstrating its capacity to remodel the lesion microenvironment through significant reduction of extracellular matrix deposition. This permissive environmental transformation facilitates robust regeneration of the reticulospinal tract, and reconstructs functional ...
Run Li, Hongyuan Xing, Yifan Shen, Meng Chen, Bowen Lyu, Xiaofeng Yang, Li Sun, Chao Jiang, Jianyu Lv, Xin Ding, Zhongyang Gao, Yue Wang   +11 more
wiley   +1 more source

Epidural Spinal Cord Stimulation Acutely Modulates Lower Urinary Tract and Bowel Function Following Spinal Cord Injury: A Case Report

Frontiers in Physiology, 2018
Regaining control of autonomic functions such as those of the cardiovascular system, lower urinary tract and bowel, rank among the most important health priorities for individuals living with spinal cord injury (SCI).
M. Walter, Amanda H. X. Lee, Alex G Kavanagh, A. Phillips, A. Krassioukov   +4 more
semanticscholar   +1 more source

Tissue‐Resident Macrophage‐Derived E3 Ligase SMURF2 Restricts Autoimmune Inflammation by Mediating the Degradation of p‐TBK1

Advanced Science, EarlyView.
Dysregulated Tissue resident macrophage (TRMs) link to autoimmune inflammation. SMURF2 mediates Lys‐27 (K27)‐linked ubiquitination of p‐TBK1 and its degradation, which inhibits CSF1R signaling‐triggered TRM proliferation, thereby restraining the autoimmune inflammation.
Xiang An, Jun Li, Lingling Wang, Chengyuan Li, Zhenpeng Jin, Yushi Yao, Minmin Jiang, Wenlong Lin, Xiaojian Wang   +8 more
wiley   +1 more source

Enhancing Nervous System Recovery through Neurobiologics, Neural Interface Training, and Neurorehabilitation. [PDF]

, 2016
After an initial period of recovery, human neurological injury has long been thought to be static. In order to improve quality of life for those suffering from stroke, spinal cord injury, or traumatic brain injury, researchers have been working to ...
Edgerton, V Reggie, Krucoff, Max O, Rahimpour, Shervin, Slutzky, Marc W, Turner, Dennis A   +4 more
core   +1 more source

Mechanical Environment Afforded by Engineered Hydrogel Critically Regulates Survival of Neural Stem Cells Transplanted in the Injured Spinal Cord via Piezo1‐Mediated Mechanotransduction

Advanced Science, EarlyView.
Neural stem cell transplantation shows promise for spinal cord repair, but poor graft survival limits therapeutic efficacy. This study demonstrates that increasing hydrogel stiffness from 10% to 16% concentration significantly enhances transplanted neural stem cell survival through Piezo1‐mediated mechanotransduction, revealing mechanical properties as
Hee Hwan Park, Yurim Kim, Byeong Seong Jang, Simay Genişcan, Dong Hoon Hwang, Yeojin Seo, Seung‐Ah Jee, Hyo Gyeong Seo, Hyung Soon Kim, Ariandokht Einisadr, Ho‐Jeong Kim, Seolhee Lee, Sangwoo Kwon, Kyung Sook Kim, Kang In Lee, Jae Young Lee, Joo Min Park, Young‐Min Kim, Soo‐Chang Song, Byung Gon Kim   +19 more
wiley   +1 more source

Spinal Cord Stimulation for Control of Pain [PDF]

, 2008
Spinal cord stimulation (SCS) is an adjustable, non-destructive procedure which delivers therapeutic doses of electrical current to the spinal cord for the management of neuropathic pain. The most common indications include post-laminectomy (“failed back
Falowski MD, Stephen
core   +1 more source

NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease

Advanced Science, EarlyView.
NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang, Yongwoo Na, Hyeonjoo Im, Garam Yang, Seungseon Yang, Hyun Soo Shim, Chunggoo Kim, GyeungYun Kim, Hyeok Ju Park, Hee Young Kim, Seung Eun Lee, Wonwoong Lee, Yoon Ha, Sungho Park, Jieun Kim, Won‐Young Cho, Woong Sun, Jong‐Seo Kim, Junsang Yoo   +18 more
wiley   +1 more source

Unintentionally intentional: unintended effects of spinal stimulation as a platform for multi-modal neurorehabilitation after spinal cord injury

Bioelectronic Medicine
Electrical stimulation of spinal neurons has emerged as a valuable tool to enhance rehabilitation after spinal cord injury. In separate parameterizations, it has shown promise for improving voluntary movement, reducing symptoms of autonomic dysreflexia ...
Gerson N. Moreno Romero, Avery R. Twyman, Maria F. Bandres, Jacob Graves McPherson   +3 more
doaj   +1 more source