Results 181 to 190 of about 1,263,722 (262)
Advanced Science, EarlyView.In this work, MSN‐BO@LUT penetrates the blood‐spinal cord barrier for luteolin delivery in spinal cord injury. The nanodrug suppresses neuroinflammation and promotes functional recovery of the spinal cord. Mechanistically, luteolin targets protein arginine N‐methyltransferase (PRMT2) to decrease toll‐like receptor 4 (TLR4) methylation, thereby ...
Yixuan Wang +11 more
wiley +1 more source
Preoperative Neurological and Neurophysiological Assessment of Patients with Idiopathic Scoliosis Treated or Not Treated with Physiotherapy: A Retrospective Comparative Study. [PDF]
Brain SciWitkowska M, Huber J, Kotwicki T.
europepmc +1 more source
A Physical Adaptive Material Motor Unit Neural Network: A Hygromorph Composite Material Machine
Advanced Science, EarlyView.This study introduces a new class of material‐based intelligent machines. It presents a Physical Adaptive Material Motor Unit Neural Network, an assembly of smart 4D printed actuators and a controlling system that adapt through environmental interaction its shading behavior.
Charles de Kergariou +2 more
wiley +1 more source
Lumbopelvic Complex Alignment Defects in Adolescents: Relationships with Temperament and Implications for Individualised Prevention and Rehabilitation Strategies. [PDF]
J Clin MedWilczyński J +6 more
europepmc +1 more source
Advanced Science, EarlyView.Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu +5 more
wiley +1 more source
Postural alignment in static and dynamic conditions in adults with and without forward head posture. [PDF]
Turk J Phys Med RehabilShin HJ, Son HH.
europepmc +1 more source
Advanced Science, EarlyView.This work designed an injectable metal‐drug supramolecular condensate formed from hafnium ions and alendronate (Hf‐ALN) and loaded with the COX‐2 inhibitor celecoxib (CXB) for synergistic radioimmunotherapy of postoperative osteosarcoma. Mechanistically, upon X‐ray irradiation, Hf enhances radiation energy deposition, ROS generation, and DNA damage ...
Tianhua Xiao +12 more
wiley +1 more source
Advanced Science, EarlyView.Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen +11 more
wiley +1 more source
The Impact of Modern Lifestyles on Spinal Health in the Pediatric Population: A Narrative Review. [PDF]
Children (Basel)Zaborowska-Sapeta K +4 more
europepmc +1 more source
Advanced Science, EarlyView.A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung +15 more
wiley +1 more source