Pathogenic Role of FGFR3 Autoantibodies in Small Fiber Neuropathy
Advanced Science, EarlyView.Autoantibodies against fibroblast growth factor receptor 3 (FGFR3) are identified as pathogenic drivers of pain in small fiber neuropathy. By binding to sensory neurons in dorsal root ganglia, FGFR3 autoantibodies activate MAPK signaling and induce hyperexcitability and mechanical hypersensitivity, establishing FGFR3 autoantibodies as a therapeutic ...
Lyuba Y. Salih +12 more
wiley +1 more source
Editorial: Integrated clinical management and neurorehabilitation for lumbosacral spinal diseases. [PDF]
Front NeurolRegmi M, Yang C.
europepmc +1 more source
Advanced Science, EarlyView.Genetic and pharmacological inhibition of SLC11A1 functioning as an H+/Fe2+ antiporter–mediated lysosomal iron accumulation in microglia promotes lysosomal lumen acidification, increases CTSD expression, enhances lysosomal myelin debris uptake and degradation, and promotes repair following white matter stroke. ABSTRACT White matter stroke (WMS) results
Lingling Qiu +11 more
wiley +1 more source
Application of functional magnetic resonance imaging in identifying responsible brain regions associated with spinal diseases related pain. [PDF]
Front Med (Lausanne)Zhang J +5 more
europepmc +1 more source
Reoperations after fusion surgeries for degenerative spinal diseases depending on cervical and lumbar regions: a national database study. [PDF]
BMC Musculoskelet Disord, 2021 Park MS +7 more
europepmc +1 more source
Versatile CRISPR‐Cas Tools for Gene Regulation in Zebrafish via an Enhanced Q Binary System
Advanced Science, EarlyView.This study introduces CRISPR‐Q, a transgenic CRISPR‐Cas system leveraging the QFvpr/QUAS binary expression platform in zebrafish. CRISPR‐Q overcomes previous challenges in achieving stable and efficient gene regulation. By enabling precise spatiotemporal control of transcript knockdown (CRISPR‐QKD) and gene activation (CRISPR‐Qa), it provides a ...
Miaoyuan Shi +13 more
wiley +1 more source
Incidence Rates and Diagnostic Trends of Perioperative Acute Transverse Myelitis in Patients Who Underwent Surgery for Degenerative Spinal Diseases: A Nationwide Epidemiologic Study of 201,769 Patients. [PDF]
Diagnostics (Basel)Kim J, Kim TH.
europepmc +1 more source
Impact of Preoperative Total Knee Arthroplasty on Radiological and Clinical Outcomes of Spinal Fusion for Concurrent Knee Osteoarthritis and Degenerative Lumbar Spinal Diseases. [PDF]
J Clin Med, 2021 Kim HJ +7 more
europepmc +1 more source
Advanced Science, EarlyView.This study employs longitudinal fluorescence imaging in transgenic mice to map post‐craniotomy cortical recovery. We identify distinct neuroimmune recovery phases: microglial structural inflammation peaks at ∼10 days, neuronal structural intensity peaks at ∼14 days and correlates with microglial activity, and functional network modularity is most ...
Guihua Xiao +13 more
wiley +1 more source
Posterior treatment of ankylosing spinal diseases with thoracolumbar fractures: a network meta-analysis. [PDF]
BMC Musculoskelet DisordShi J +5 more
europepmc +1 more source