Results 141 to 150 of about 230,819 (312)

A Wireless Cortical Surface Implant for Diagnosing and Alleviating Parkinson's Disease Symptoms in Freely Moving Animals

open access: yesAdvanced Healthcare Materials, EarlyView.
A wireless cortical surface implant employing graphene electrode arrays diagnoses and alleviates Parkinson's disease symptoms in freely moving animals. The device continuously monitors cortical activity and delivers targeted stimulation, restoring beta–gamma and delta oscillations.
Hongseong Shin   +15 more
wiley   +1 more source

The Effects of Acute Lipopolysaccharide Induced Inflammation on Spinal Cord Excitability [PDF]

open access: yes, 2018
Peripheral inflammation alters the excitability of dorsal horn interneurons and increases flexor reflex strength (Dubner & Ruda, 1992); however, its effect on the spinal stretch reflex is not well understood. The stretch reflex is a muscle contraction in
Sanghera, Puneet
core   +1 more source

Simvastatin-hydroxyapatite coatings prevent biofilm formation and improve bone formation in implant-associated infections

open access: yesBioactive Materials, 2023
Implant-associated infections (IAIs) caused by biofilm formation are the most devastating complications of orthopedic surgery. Statins have been commonly and safely used drugs for hypercholesterolemia for many years.
Tiantong Sun   +8 more
doaj  

Engineered Chitosan‐Derived Nanocarrier for Efficient siRNA Delivery to Peripheral and Central Neurons

open access: yesAdvanced Healthcare Materials, EarlyView.
This study introduces a novel chitosan‐based nanocarrier functionalized with a neurotropic protein for efficient siRNA delivery to neurons. The polyplexes demonstrate enhanced neuronal binding, retrograde transport, and PTEN silencing, promoting axonal outgrowth.
Ana P. Spencer   +10 more
wiley   +1 more source

Ultrasound of the hand is sufficient to detect subclinical inflammation in rheumatoid arthritis remission: a post hoc longitudinal study

open access: yesArthritis Research & Therapy, 2017
Background Ultrasound (US) is a sensitive method for detecting joint/tendon inflammation in patients with rheumatoid arthritis (RA). Subclinical inflammation is often found in patients with RA in composite score remission.
Hilde Berner Hammer   +2 more
doaj   +1 more source

SpineMamba: Enhancing 3D Spinal Segmentation in Clinical Imaging through Residual Visual Mamba Layers and Shape Priors [PDF]

open access: yesarXiv
Accurate segmentation of 3D clinical medical images is critical in the diagnosis and treatment of spinal diseases. However, the inherent complexity of spinal anatomy and uncertainty inherent in current imaging technologies, poses significant challenges for semantic segmentation of spinal images.
arxiv  

Immunosuppressive Formulations for Immunological Defense against Traumatic Brain Injury

open access: yesAdvanced Healthcare Materials, EarlyView.
A novel subcutaneous formulation combining alpha‐ketoglutarate, glycolysis inhibitor PFK15, and a myelin peptide reduces inflammation in a mouse TBI model. This formulation promotes regulatory immune cells, enhances autophagy, and improves motor function, suggesting its potential as a prophylactic immunosuppressive therapy to mitigate TBI‐induced ...
Kelly Lintecum   +28 more
wiley   +1 more source

High‐Resolution Patterned Delivery of Chemical Signals From 3D‐Printed Picoliter Droplet Networks

open access: yesAdvanced Materials, EarlyView.
3D‐printed picoliter droplet networks have been fabricated that control gene expression in bacterial populations by releasing chemical signals with precise spatial definition and high temporal resolution. This system of effector release is widely applicable, offering diverse applications in biology and medicine.
Jorin Riexinger   +7 more
wiley   +1 more source

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