Results 101 to 110 of about 1,574,797 (410)

Engineering Cortical Networks: An Open Platform for Controlled Human Circuit Formation and Synaptic Analysis In Vitro

Advanced Healthcare Materials, EarlyView.
An advanced on‐chip cortical network platform merges human stem cell‐derived neurons with microfabricated devices, enabling precise large‐format circuit design, optogenetic control, and molecular dissection of synaptic formation. This innovative system offers a powerful new tool to explore and model brain connectivity, disease mechanisms, can serve as ...
Pacharaporn Suklai, Taylor Minckley, Cathleen Hagemann, Karolina Faber, Rosalind Norkett, Ludovica Guetta, Kelly O'Toole, Bethany Geary, Michael J. Devine, Andrea Serio   +9 more
wiley   +1 more source

Targeted Delivery of Abaloparatide to Spinal Fusion Site Accelerates Fusion Process in Rats

Biomedicines
Spinal fusions are performed to treat congenital skeletal malformations, spondylosis, degenerative disk diseases, and other pathologies of the vertebrae that can be resolved by reducing motion between neighboring vertebrae.
Jeffery J. Nielsen, Stewart A. Low, Christopher Chen, Xinlan Li, Ephraim Mbachu, Lina Trigg, Siyuan Sun, Madeline Tremby, Rahul Hadap, Philip S. Low   +9 more
doaj   +1 more source

Behavioral recovery and spinal motoneuron remodeling after polyethylene glycol fusion repair of singly cut and ablated sciatic nerves.

PLoS ONE, 2019
Polyethylene glycol repair (PEG-fusion) of severed sciatic axons restores their axoplasmic and membrane continuity, prevents Wallerian degeneration, maintains muscle fiber innervation, and greatly improves recovery of voluntary behaviors.
Cameron L Ghergherehchi, Emily A Hibbard, Michelle Mikesh, George D Bittner, Dale R Sengelaub   +4 more
doaj   +1 more source

Effects of teriparatide and bisphosphonate on spinal fusion procedure: A systematic review and network meta-analysis.

PLoS ONE, 2020
BackgroundGiving patients anti-osteoporotic agents peri-operatively is a well-accepted strategy to increase fusion rate and prevent complications. The purpose of this study was to investigate effectiveness of teriparatide and bisphosphonate on fusion ...
Shih-Hao Cheng, Yi-Jie Kuo, Chiehfeng Chen, Yi-No Kang   +3 more
doaj   +1 more source

The efficacy of allograft bone using titanium mesh in the posterior-only surgical treatment of thoracic and thoracolumbar spinal tuberculosis

BMC Surgery, 2020
Background The bony fusion of allograft bone using titanium mesh in the posterior-only surgical treatment of thoracic and thoracolumbar spinal tuberculosis has not been explained in detail.
Bingjin Wang, Wenbin Hua, Wencan Ke, Yukun Zhang, Xianlin Zeng, Cao Yang   +5 more
doaj   +1 more source

Short-term Osteoclastic Activity Induced by Locally High Concentrations of Recombinant Human Bone Morphogenetic Protein–2 in a Cancellous Bone Environment [PDF]

, 2009
Study Design. An experimental study investigating osteoclastic activity induced by rhBMP-2 in sheep. Objective. To examine the effects of increasing local rhBMP-2 concentration on osteoclastic response and peri-implant bone resorption.
Badura, Jeffrey, Boden, Scott D., Burkus, J. Kenneth, McKay, William, Peckham, Steve M., Toth, Jeffrey M.   +5 more
core   +1 more source

Granular Hydrogels as Modular Biomaterials: From Structural Design to Biological Responses

Advanced Healthcare Materials, EarlyView.
Granular hydrogels are now emerging as promising biomaterials due to their inherent microporousity, injectability, and modularity. They have shown improvements in cell viability and migration, cellular/tissue infiltration, host tissue integration, mitigated foreign body response, and tissue regeneration.
Asmasadat Vaziri, Renata Maia, Pei Zhang, Liliana Agresti, Jelmer Sjollema, Mohammad‐Ali Shahbazi, Hélder A. Santos   +6 more
wiley   +1 more source

Bio‐Inspired Artificial Muscle‐Tendon Complex of Liquid Crystal Elastomer for Bidirectional Afferent‐Efferent Signaling

Advanced Materials, EarlyView.
The Muscle–tendon complex (MTC)‐inspired Liquid crystal elastomer (LCE) artificial muscle integrates actuation (efferent) and proprioceptive sensing (afferent) by combining contractile nematic and elastic isotropic LCEs within a single soft structure. Embedded liquid metal channels enable simultaneous Joule heating and real‐time sensing of length and ...
Jiyeon Cho, Minhee Lee, Taejun Park, Yang Wang, Howon Lee, Shengqiang Cai, Yong‐Lae Park   +6 more
wiley   +1 more source

The Use of Bone Morphogenetic Protein in the Intervertebral Disk Space in Minimally Invasive Transforaminal Lumbar Interbody Fusion [PDF]

, 2019
Study Design: Retrospective Cohort. Objective: The objective of this study was to characterize one surgeon’s experience over a 10-year period using rhBMP-2 in the disk space for minimally invasive transforaminal lumbar interbody fusion (MIS TLIF ...
Anderson, Annis, Cahill, Carragee, Chen, Crandall, Djurasovic, Fan, Foley, Fu, Funao, Gianaris, Gu, Haid, Hoffmann, Hu, Kelly, Khan, Khan, Kim, McGirt, Phan, Phan, Rihn, Rihn, Sawchuk, Singh, Spitz, Wang   +28 more
core   +1 more source

Bioprinted Constructs in the Regulatory Landscape: Current State and Future Perspectives

Advanced Materials, EarlyView.
Bioprinting has rapidly emerged as a transformative technology in biomedical research, offering unprecedented potential to replicate complex tissues. Despite its promise, clinical translation remains limited due to regulatory hurdles. This review explores global regulatory frameworks, comparing approaches in the EU, U.S., China, and Australia, and ...
Francesca Perin, Liliang Ouyang, Khoon S. Lim, Antonella Motta, Devid Maniglio, Lorenzo Moroni, Carlos Mota   +6 more
wiley   +1 more source