Results 151 to 160 of about 1,555,237 (407)

Human iPSCs Derived MSCs‐Secreted Exosomes Modulate Senescent Nucleus Pulposus Cells Induced Macrophage Polarization via Metabolic Reprogramming to Mitigate Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Senescent nucleus pulposus cells drive inflammatory M1 macrophage polarization, exacerbating intervertebral disc degeneration (IDD). Conversely, M1 macrophages accelerate NP cell senescence, creating a vicious cycle. iPSCs‐derived mesenchymal stem cell (iMSCs) exosomes break this loop by delivering miR‐100‐5p to suppress mTORC1/glycolysis in ...
Qian Xiang, Jiawen Zhan, Shuo Tian, Yongzhao Zhao, Zhenquan Wu, Jialiang Lin, Longting Chen, Longjie Wang, Shuai Jiang, Zhuoran Sun, Weishi Li   +10 more
wiley   +1 more source

Spinal fusion surgery use among adults with low back pain enrolled in a digital musculoskeletal program: an observational study

BMC Musculoskeletal Disorders
Objectives To compare 12-month spinal fusion surgery rates in the setting of low back pain among digital musculoskeletal (MSK) program participants versus a comparison cohort who only received usual care.
Sandhya Yadav, Laura S. Gold, Qasim Hassan Zaidi, Raymond Hwang, Louie Lu, Grace Wang   +5 more
doaj   +1 more source

Mesenchymal Stromal Cells Play an Analgesic Role Through a Npy2r Sensory Neuron‐Mediated Lung‐to‐Brain Axis

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSC) are considered a promising alternative for neuropathic pain (NP) treatment, but underlying mechanisms remain elusive. Huang et al. illustrate that a Npy2r sensory neuron‐related lung–brain axis contributes to MSC analgesia.
Jing Huang, Taihe Zhou, Yueming Sun, Yuanchen Ma, Yiwen Deng, Keyu Chen, Ruijie Li, Yuan Qiu, Tao Wang, Xiaoyong Chen, Li Huang, Lu Zhu, Xueyi Tu, Ying Wang, Zheming Liu, Rouchen Lin, Yunli Tong, Yuantao Li, Heshe Li, Lin Nie, Rui Fang, Jianqi Feng, Xuhong Wei, Xia Feng, Andy Peng Xiang, Xiaoran Zhang   +25 more
wiley   +1 more source

Aerobic and Anaerobic Microbiology of Surgical-Site Infection Following Spinal Fusion [PDF]

, 1999
Itzhak Brook, Edith H. Frazier
openalex   +1 more source

Targeting Hyperglycemic Bone Pre‐Metastatic Niche for Breast Cancer Bone Metastasis Therapy

Advanced Science, EarlyView.
This study reveals that breast cancer creates a hyperglycemic pre‐metastatic niche in bone prior to colonization and amplifies glucose metabolism post‐metastasis. To target this mechanism, a biomimetic enzyme‐engineered nanoplatform that disrupts tumor glycolytic pathways, proposing a therapeutic strategy to inhibit breast cancer bone metastasis by ...
Jianxin Ye, Peng Hu, Rui Zhang, Lei Zhou, Zonghua Luo, Yanan Chen, Shengzhe Ruan, Mengyi Zhu, Huaze Ding, Yike Qian, Yan Xing, Tong Meng, Changping Wang, Dianwen Song   +13 more
wiley   +1 more source

Clinical and surgical management of holocervical spinal cord ependymomas. [PDF]

, 2019
Background:Spinal ependymomas are rare tumors of the central nervous system, and those spanning the entire cervical spine are atypical. Here, we present two unusual cases of holocervical (C1-C7) spinal ependymomas.
Attiah, Mark, Batzdorf, Ulrich, Churchman, Pedro, Gaonkar, Bilwaj, Macyszyn, Luke, Mckay, Kevin, Moreland, Natalie, Nagasawa, Daniel, Niu, Tianyi, Patel, Kunal, Tucker, Alexander, Van de Wiele, Barbara   +11 more
core  

Activities and functional assessment 1 year after spinal fusion for paralytic scoliosis [PDF]

, 1999
E Larsson, S. Aaro, Birgitta Öberg
openalex   +1 more source

Dislocation of a primary total hip arthroplasty is more common in patients with a lumbar spinal fusion

The Bone & Joint Journal, 2017
A. Buckland, A. Buckland, V. Puvanesarajah, V. Puvanesarajah, J. Vigdorchik, Ran Schwarzkopf, Amit Jain, E. Klineberg, R. Hart, J. Callaghan, J. Callaghan, H. Hassanzadeh, H. Hassanzadeh   +12 more
semanticscholar   +1 more source

Decoding Handwriting Trajectories from Intracortical Brain Signals for Brain‐to‐Text Communication

Advanced Science, EarlyView.
By developing a novel framework that optimizes both shape and temporal loss during decoder training, the authors successfully reconstruct human‐recognizable handwriting trajectories from intracortical neural signals for both Chinese characters and English letters, effectively resolving the temporal misalignment problem in clinical BCIs, thereby ...
Guangxiang Xu, Zebin Wang, Kedi Xu, Junming Zhu, Jianmin Zhang, Yueming Wang, Yaoyao Hao   +6 more
wiley   +1 more source

Posterior Fusion in a Case of Lenke Type 2 Adolescent Idiopathic Scoliosis with Severe Factor VII Deficiency: A Case Report

Journal of Orthopedic and Spine Trauma
Background: Congenital factor VII (FVII) deficiency is a rare autosomal recessive coagulation disorder that poses significant challenges during major surgeries, particularly high-risk procedures like instrumented spinal fusion for adolescent idiopathic ...
Maziar Malekzadeh, Babak Mrzashahi, Siamak Shabani   +2 more
doaj   +1 more source