Results 211 to 220 of about 1,356,051 (302)

PHGDH‐Mediated Serine Metabolism in Nucleus Pulposus Cells Is a Potential Therapeutic Target for Intervertebral Disc Degeneration

Advanced Science, EarlyView.
When nucleus pulposus cells senesce, PHGDH decreases, reducing serine synthesis and glutathione, impairing antioxidant capacity. The intermediate α‐KG also drops, lowering JMJD3 demethylase activity, increasing H3K27me3 at the Rap1b promoter, and reducing Rap1b expression, whose down‐regulation in turn activates mTORC1 and suppresses autophagy ...
Hao‐Wei Xu, Sheng‐Jie Chang, Xiao‐Wei Liu, Shu‐Bao Zhang, Ying‐Jie Wang, Shan‐Jin Wang   +5 more
wiley   +1 more source

SynAtlas: A Safe and Versatile Platform for Rapid Organ‐Scale Tissue Clearing and 3D Atlas Mapping

Advanced Science, EarlyView.
An orthogonal synergy design principle integrates lipid solubilization, protein hydration modulation, and refractive‐index matching within a unified aqueous clearing system. This modular strategy enables rapid, low‐hazard, and broadly compatible tissue clearing while preserving molecular signals, supporting multiscale three‐dimensional imaging across ...
Mei‐Xue Yuan, Xin‐Ya Qin, Ling‐Jie Li, Kai‐Lang Xiao, Meng‐Meng Zhang, Kun‐Qi Chen, Peng Chen, Yu Wang, Chen‐Wei Wang, Nan Zhou, Qing‐Hong Shan   +10 more
wiley   +1 more source

Bone Growth Stimulators to Enhance Spinal Fusion Outcomes. [PDF]

Spine Surg Relat Res
Melvin TP, Elbooz A, Foster D, Brutti J, Lee A, Voros A.   +5 more
europepmc   +1 more source

Composition‐Aware Cross‐Sectional Integration for Spatial Transcriptomics

Advanced Intelligent Discovery, EarlyView.
Multi‐section spatial transcriptomics demands coherent cell‐type deconvolution, domain detection, and batch correction, yet existing pipelines treat these tasks separately. FUSION unifies them within a composition‐aware latent framework, modeling reads as cell‐type–specific topics and clustering in embedding space.
Qishi Dong, Zijian Huang, Xuanwu Wang, Zhenghui Feng, Wei Liu, Bingding Huang   +5 more
wiley   +1 more source

Intraoperative traction in posterior spinal fusion for adolescent idiopathic scoliosis: an updated systematic review and meta-analysis of correction, perioperative, and safety outcomes. [PDF]

Front Pediatr
Tang Q, Xu R, Zhang L, Liu H, Wang W.
europepmc   +1 more source

Sports Activity Recognition Using Textile‐Based Sensor Fusion and Complex‐Valued Residual Convolutional Neural Networks

Advanced Intelligent Systems, EarlyView.
Motion artifacts in electrocardiographic signals, conventionally dismissed as noise, are shown to encode discriminative activity information. A smart t‐shirt fusing textile strain sensors with textile ECG electrodes, processed through a complex‐valued residual network, recognizes 12 sport activities.
Nada Al‐azzawi, Munire Sibel Cetin, Asli Tuncay Atalay, Ozgur Atalay, Gökhan Ince   +4 more
wiley   +1 more source

Surgical outcomes following spinal fusion for cervical versus noncervical fractures in ankylosing spondylitis and DISH. [PDF]

N Am Spine Soc J
Yoon K, Sabha M, Quan T, Bui V, Lee L, Bellaire CP, Ehioghae M, Japa JP, Mesfin A.   +8 more
europepmc   +1 more source

Miniaturized Multifunctional Valves for Intelligent Pneumatic Systems in Soft Robotics

Advanced Intelligent Systems, EarlyView.
Miniaturized multifunctional pneumatic valves in normally closed (NC) and normally open (NO) configurations enable reconfigurable and programmable fluidic logic—including AND, OR, NAND, and NOR gates—with/without physical replumbing. These valves integrate sensing, logic, and actuation within a unified architecture, demonstrated through an electronics ...
J. Xu, X. Z. Niu, J. Andersson, D./G. Broo, K. Hjort   +4 more
wiley   +1 more source

Rates of Subsequent Lumbar Surgery Following Spinal Fusion in Patients With Parkinson Disease: A Propensity-Score Matched Nationwide Cohort Analysis. [PDF]

Neurospine
Ham CH, Kim JH, Kim JH, Byun J, Moon HJ, Kwon WK.   +5 more
europepmc   +1 more source