Results 281 to 290 of about 193,493 (357)

The evolving therapeutic landscape of spinal muscular atrophy – A scoping review of investigational agents, emerging delivery technologies and strategic innovations

British Journal of Clinical Pharmacology, EarlyView.
Spinal muscular atrophy (SMA) is a severe neuromuscular disease with emerging therapeutic complexity. This review aims to systematically map the global pipeline of investigational treatments for SMA. Using ClinicalTrials.gov and complementary international registries, we identified 21 planned or ongoing interventional trials from 2020 to 2025 targeting
Andrej Belančić, Patrick Eustaquio, Elvira Meni Maria Gkrinia, Ivana Stević, Eugen Javor, Yun Wah Lam, Slobodan Janković, Dinko Vitezić   +7 more
wiley   +1 more source

Navigating the Curve: The Rising Use of Intraoperative Navigation in Posterior Spinal Fusion for Early-onset Scoliosis in the United States. [PDF]

J Pediatr Soc North Am
Koschmeder KT, Haglin JM, Zeller AM, Karlen JW, Bennett DM.   +4 more
europepmc   +1 more source

Low back pain and radicular pain : assessment and management [PDF]

, 2017
Ailiet, Luc, Berquin, Anne, Depreitere, Bart, Desomer, Anja, Dewachter, Johan, Dolphens, Mieke, Dumoulin, Christophe, Forget, Patrice, Fraselle, Virginie, Hans, Guy, Hoste, Davy, Jonckheer, Pascale, Mahieu, Geneviève, Michielsen, Jef, Nielens, Henrie, Orban, Thomas, Parlevliet, Thierry, Simons, Emmanuel, Tobbackx, Yannick, Van Wambeke, Peter, Van Zundert, Jan, Vanderstraeten, Jacques, Vanschaeybroeck, Patrick, Vlaeyen, Johan   +23 more
core   +1 more source

Adaptive Machine Learning Framework for Optimizing the Affinity Purification of Adeno‐Associated Viral Vectors

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Adeno‐associated viral (AAV) vectors for gene therapy are becoming integral to modern medicine, providing therapeutic options for diseases once deemed incurable. Currently, viral vector purification is a critical bottleneck in the gene therapy industry, impacting product efficacy and safety as well as accessibility and cost to patients ...
Kelvin P. Idanwekhai, Shriarjun Shastry, Morgan R. Hurst, Arianna Minzoni, Eduardo Barbieri, Luke Remmler, Eugene N. Muratov, Michael A. Daniele, Stefano Menegatti, Alexander Tropsha   +9 more
wiley   +1 more source

BIOABSORBABLE CAGES IN SPINAL FUSION IN AN ANIMAL MODEL: A SYSTEMATIC REVIEW AND META-ANALYSIS. [PDF]

Acta Ortop Bras
Mistro S, Risso MI, Grana RM, Lima MC, Rosa AF, Cliquet A.   +5 more
europepmc   +1 more source

Exosome as bioactive nanovesicle for diagnostic and therapeutic applications in periodontitis

BMEMat, EarlyView.
This review introduces the mechanism that exosomes participate in the pathogenesis of periodontitis and their potential as biomarkers for early diagnosis and summarizes the application of cell‐ or plant‐derived exosomes or engineered exosomes in periodontitis or periodontal regeneration while proposing the perspective of translational application of ...
Yu Wang, Yuchen Li, Yunfan Zhang, Chenshuang Li, Yifan Lin, Si Chen, Bing Han   +6 more
wiley   +1 more source

A retrospective review of continuous epidural analgesia following posterior spinal instrumented fusion for adolescent idiopathic scoliosis

Maisha Jamali, Gregory Moloney, Maree Izatt, Simon Gatehouse, Adam Parr, Robert Labrom, Geoffrey Askin, Dimitrios Vagenas, J.Paige Little   +8 more
openalex   +2 more sources

Staged Halo-Pelvic Traction Combined With Posterior Spinal Fusion versus One-Stage Surgery for Severe Rigid Spine Deformity Requiring Three-Column Osteotomy: A Comparative Study. [PDF]

Global Spine J
Yang H, Huang J, Yang Y, Geng H, Zhang Y, Wang Y, Zhang Y, Zhou L, Hai Y.   +8 more
europepmc   +1 more source

Biomaterial design strategies for enhancing mitochondrial transplantation therapy

BMEMat, EarlyView.
Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang, Yushan Zhang, Hang Li, Sirui Peng, Donghao Lyu, Chunxiao Zhou, Sheng Ding, Zujian Feng, Pingsheng Huang, Chuangnian Zhang, Hongjun Wang, Deling Kong, Weiwei Wang   +12 more
wiley   +1 more source

Thoracic Fracture Adjacent to Spinal Fusion Following Cardiopulmonary Resuscitation: A Case Report. [PDF]

Cureus
Liebeskind M, Clarke JE, Huang JC.
europepmc   +1 more source