Results 71 to 80 of about 1,555,237 (407)
Opioids Delay Healing of Spinal Fusion: A Rabbit Posterolateral Lumbar Fusion Model [PDF]
, 2018 Background Context Opioid use is prevalent in the management of pre- and postoperative pain in patients undergoing spinal fusion. There is evidence that opioids downregulate osteoblasts in vitro, and a previous study found that morphine delays the ...
Briley, Karen C. +5 more
core +1 more source
Advanced Functional Materials, EarlyView.A potent anionic citric acid‐based 3D‐printed scaffold is developed for the sustained and controlled release of orthobiologics to enhance orthopedic therapeutic efficacy. Comprehensive in vivo studies demonstrated effective bone fusion and high safety at a low dose of BMP‐2 delivered by the system, establishing it as a promising platform for safe ...
Se‐Hwan Lee +12 more
wiley +1 more source
Journal of Orthopaedic Surgery and Research, 2020 Background Despite widespread use of femoral-sourced allografts in clinical spinal fusion procedures and the increasing interest in using femoral reamer–irrigator–aspirator (RIA) autograft in clinical bone grafting, few studies have examined the efficacy
Christina Holmes +7 more
doaj +1 more source
Relationship between thoracic kyphosis and neural axis abnormalities in patients with adolescent idiopathic scoliosis. [PDF]
, 2018 Purpose:Previous studies have suggested an association between increased thoracic kyphosis and neural axis abnormalities in patients with adolescent idiopathic scoliosis (AIS). However, the basis for this finding is unclear, and this association has been
Blanco, J +5 more
core +2 more sources
Functional Hydrogel for Modulating Lipid Droplets and Neuroinflammation in Head Injury
Advanced Functional Materials, EarlyView.After TBI, elevated cholesterol levels in activated microglia lead to the accumulation of cholesterol esters in lipid droplets, exacerbating neuroinflammation. A β‐cyclodextrin‐conjugated GelMA (βCD‐GelMA) hydrogel is developed to promotes cholesterol efflux and reduces LDL influx, thereby alleviating intracellular cholesterol and lipid droplet buildup.
Feixiang Chen +9 more
wiley +1 more source
PLoS ONE, 2020 BackgroundGiving patients anti-osteoporotic agents peri-operatively is a well-accepted strategy to increase fusion rate and prevent complications. The purpose of this study was to investigate effectiveness of teriparatide and bisphosphonate on fusion ...
Shih-Hao Cheng +3 more
doaj +1 more source
BMC Musculoskeletal Disorders, 2022 Background Previous studies have reported that vitamin D supplement could improve fracture healing, but evidence regarding the role of vitamin D supplements in spinal fusion was limited.
Ming-Hsien Hu +5 more
doaj +1 more source
Iatrogenic Spinal Cord Injury Resulting From Cervical Spine Surgery. [PDF]
, 2017 STUDY DESIGN: Retrospective cohort study of prospectively collected data. OBJECTIVE: To examine the incidence of iatrogenic spinal cord injury following elective cervical spine surgery.
Arnold, Paul M. +15 more
core +2 more sources
Advanced Functional Materials, EarlyView.Spinal cord injury (SCI) poses significant challenges for regeneration due to a series of secondary injury mechanisms. How to use biomaterial approach to target the failed regeneration after SCI remains a critical challenge. This review systematically evaluates current strategies to optimize biomaterial topographies for neurite outgrowth, axonal ...
Wei Xu +7 more
wiley +1 more source
Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes
Advanced Functional Materials, EarlyView.Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth +2 more
wiley +1 more source