Results 71 to 80 of about 99,877 (265)

Intraoperative antepulsion of a posterior lumbar interbody fusion cage: three case reports

The Pan African Medical Journal, 2015
Spinal fusion surgery techniques develop together with technologic advancements. New complications are seen as the result of new techniques and these may be very severe due to spinal cord and vascular structures in the lumbar region. The posterior lumbar
Davut Ceylan, Can Yaldiz, Kiyasettin Asil, Tibet Kaéira, Necati Tatarli, Aytaé Can   +5 more
doaj   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

Risk Factors for Sacroiliac Joint Fusion after Instrumented Spinal Fusion

Global Spine Journal
Study Design Retrospective Cohort Study. Objective To identify risk factors for sacroiliac (SI) joint fusion after instrumented spinal fusion. Methods Patients were identified from the PearlDiver BiscayneBay database. Patients who underwent 1 level (CPT:
Peter Z Du MD, Gurmit Singh MD, Spencer Smith BS, Travis Philipp MD, Jonathan Kark MD, Clifford Lin MD, Jung U Yoo MD   +6 more
doaj   +1 more source

Surgery for spinal deformity with osteoporosis: Achieving successful fusion

Osteoporosis and Sarcopenia
The objectives of fusion surgery for spinal deformities include decompressing neural elements and achieving balanced spinal alignment. Particularly, in cases where spinal deformities coexist with osteoporosis, successful surgery requires careful ...
Myung-Sup Ko, Hyung-Youl Park, Young-Il Ko, Sang-Il Kim, Young-Hoon Kim   +4 more
doaj   +1 more source

Behavioral recovery and spinal motoneuron remodeling after polyethylene glycol fusion repair of singly cut and ablated sciatic nerves.

PLoS ONE, 2019
Polyethylene glycol repair (PEG-fusion) of severed sciatic axons restores their axoplasmic and membrane continuity, prevents Wallerian degeneration, maintains muscle fiber innervation, and greatly improves recovery of voluntary behaviors.
Cameron L Ghergherehchi, Emily A Hibbard, Michelle Mikesh, George D Bittner, Dale R Sengelaub   +4 more
doaj   +1 more source

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

Protein Disulfide Isomerase Disassembles TDP‐43/G3BP1 Condensates and Antagonizes TDP‐43 Pathological Aggregates

Advanced Science, EarlyView.
Cytoplasmic aggregation of TDP‐43 is a common pathological feature in amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and Alzheimer's disease with TDP‐43 pathology. This study reports that wild‐type PDI slows down phase separation of TDP‐43 through direct interaction with TDP‐43.
Jia‐Qi Liu, Hao Liu, Yu‐Xuan Sun, Yuying Li, Xiangyi Liu, Li‐Qiang Wang, Zhaofei Yang, Qi Fu, Xiaojiao Xu, Jie Chen, Yingshuang Zhang, Jun Zhou, Weidong Le, Mengchao Cui, Yi Liang   +14 more
wiley   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Accuracy and reliability of radiological methods for assessing fusion rates in patients undergoing spinal arthrodesis and stabilization: a systematic review of the past 10 years

Frontiers in Surgery
BackgroundReliable assessment of spinal fusion remains a significant challenge due to the absence of universally accepted radiological criteria. Despite the widespread use of spinal arthrodesis and stabilization, substantial variability persists in how ...
Gabriele Bilancia, Deyanira Contartese, Federica Delbello, Giuseppe Tedesco, Francesca Salamanna, Cristiana Griffoni, Alessandro Gasbarrini, Alessandro Gasbarrini, Gianluca Giavaresi, Paolo Spinnato   +9 more
doaj   +1 more source

Minimally Invasive Spinal Fusion Using Percutaneous Pedicle Screw Instrumentation Can Provide a Better Health-Related QOL in Early Stage Than Conventional Methods in the Treatment of Single-Level Degenerative Lumbar Spinal Diseases

Clinical Interventions in Aging, 2023
Masumi Iwabuchi,1 Ryoji Tominaga,1 Jun Komatsu,1,2 Osamu Shirado1 1Department of Orthopaedic and Spinal Surgery, Aizu Medical Center at Fukushima Medical University, Aizuwakamatsu, Fukushima, Japan; 2Department of Medicine for Motor Organs, Juntendo ...
Iwabuchi M, Tominaga R, Komatsu J, Shirado O   +3 more
doaj