Results 121 to 130 of about 1,373,989 (257)

Understanding inter-individual variability of experimental pain habituation and conditioned pain modulation in healthy individuals

Scientific Reports
Although reduced experimental pain habituation is proposed as a proxy of diminished endogenous pain modulatory capacity in chronic pain, prior studies show contradictory findings.
Iara De Schoenmacker, Paulina S. Scheuren, Laura Sirucek, Robin Lütolf, Lindsay M. Gorrell, Jan Rosner, Armin Curt, Petra Schweinhardt, Michèle Hubli   +8 more
doaj   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

Rehabilitation of the lower extremities, standing and walking function in people with spinal cord injury or disease: Guideline of the German-Speaking Medical Society for Spinal Cord Injury

GMS German Medical Science
Introduction: According of the level and severity of the spinal cord injury or disease (SCI/D), and the impairment of motor, sensory, and autonomic functions, individuals with SCI/D recover some standing and walking capabilities.
Irrgang, Sophie, Himmelhaus, Sandra, Allek, Kirstin, Bartholet, Claudio, Bersch-Porada, Ines, Curt, Armin, Huber, Burkhart, Kuhn, Daniel, Kynast, Karen, Weidner, Norbert, Scheel-Sailer, Anke   +10 more
doaj   +1 more source

Co‐Delivery of Sustained Release Chondroitinase ABC‐37 With Human iPSC‐Derived Neural Progenitors Promotes Transplant Survival and Functional Recovery in a Rodent Model of Stroke

Advanced Science, EarlyView.
A regenerative strategy for stroke combines human stem cell–derived neural progenitor cells with sustained release of a matrix‐modifying, thermostable chondroitinase ABC‐37 enzyme. In a rat model of stroke, co‐delivery enhanced transplanted cell survival and neuronal differentiation, degraded inhibitory extracellular matrix components, and improved ...
Nitzan Letko Khait, David Xinzheyang Li, Keyi Guo, Hong Cui, Quinton Sirianni, Dhana Abdo, Cindi M. Morshead, Molly S. Shoichet   +7 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Temporal summation in human peripheral axons when stimulated transcutaneously with a 10‐kHz waveform

Experimental Physiology
Transcutaneous spinal cord stimulation, as used for rehabilitation of impaired motor function after spinal cord injury, often involves a 10‐kHz waveform modulated to produce repetitive bursts of stimulation.
Billy L. Luu, Harrison T. Finn, Terry Trinh, Simon C. Gandevia, Martin E. Héroux, Jane E. Butler   +5 more
doaj   +1 more source

The Mind From Within: Visceral Roots of Human Cognition

Advanced Science, EarlyView.
The physiological activity of visceral organs, such as the heart, the lungs, and the gut, is surprisingly linked to many sophisticated mental operations, such as remembering the past, being aware of ourselves, making choices, and forging social bonds.
Alessandro Monti, Salvatore Maria Aglioti   +1 more
wiley   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Prediction Model for the Presence of Complications at Admission to Rehabilitation After Traumatic Spinal Cord Injury

, 2018
Background: Complications frequently occur in patients with spinal cord injury (SCI) during acute care or rehabilitation and have an impact on rehabilitation outcomes.
Maria Rosaria Porto, Torre M., Giorgio Scivoletto, Marco Iosa, Porto M. R., Iosa M., Monica Torre, Marco Molinari, Scivoletto G., Molinari M.   +9 more
core   +1 more source

Traumatic spinal injury-related hospitalizations in the United States, 2016-2019: a retrospective study. [PDF]

Int J Surg, 2023
Sun J, Yuan W, Zheng R, Zhang C, Guan B, Ding J, Chen Z, Sun Q, Fu R, Chen L, Zhou H, Feng S.   +11 more
europepmc   +1 more source