Results 151 to 160 of about 1,373,989 (257)

A Multidimensional Engineering Strategy Reprograms Microglia via Targeted and Sustained‐Release Extracellular Vesicles for Spinal Cord Injury Repair

Advanced Science, EarlyView.
A multifunctional EV‐based nanoplatform (Ang‐TEVs@Gel) was engineered via preconditioning, surface targeting, and ROS‐responsive hydrogel encapsulation to reprogram microglia. This system restored autophagy via miR‐664a‐3p/PIK3CA axis, cleared myelin debris, resolved neuroinflammation, and promoted axon remyelination, ultimately achieving robust motor ...
Wu Xiong, Minhao Liu, Mingming Zheng, Jizhou Jia, Ziyan Zhu, Guang Kong, Jie Liu, Juan Wang, Wenbo Li, Qingyuan Wang, Qian Zhu, Peiran Chan, Tao Qin, Jiayang Wu, Yongjie Zhang, Chunming Tang, Cong Li, Jin Fan   +17 more
wiley   +1 more source

Cervical spinal injury associated with patient positioning during percutaneous nephrolithotomy. [PDF]

Urol Case Rep
Kumar R, Olmstead T, Monga M.
europepmc   +1 more source

Association between injury severity scores and clinical outcomes in patients with traumatic spinal injury in an aging Japanese society. [PDF]

Medicine (Baltimore), 2023
Tsukuda M, Kumagai G, Wada K, Asari T, Nitobe Y, Tsuda E, Ishibashi Y.   +6 more
europepmc   +1 more source

Self‐Amplified Activatable Fluorescent Probe for Early Diagnosis of Acute Kidney Injury and High‐Throughput Screening of Natural Protectants

Advanced Science, EarlyView.
The PS‐QRC nanoprobe employs L‐serine as a targeting ligand for kidney injury molecule‐1 (KIM‐1) to achieve accumulation in injured renal tissues. Upon activation by reactive oxygen species (ROS), it undergoes a self‐amplifying cascade to release fluorophores for near‐infrared fluorescence (NIRF) imaging, enabling ultra‐early diagnosis of acute kidney ...
Yahui Chen, Meihong Liu, Mengchao Ding, Ye Liu, Chuanxu Zhu, Mingye Gong, Zhixuan Huang, Yi Zhang, Wei Xue, Youyong Yuan, Kewei Wang   +10 more
wiley   +1 more source

Predicting neurological recovery after thoracolumbar spine trauma: The role of injury morphology and admission American Spinal Injury Association Impairment Scale grade. [PDF]

J Craniovertebr Junction Spine
Khursheed A, Ayoub I, Fayaz M, Reza A, Chhiber SS.   +4 more
europepmc   +1 more source

Retracted: Application of Multimodal Fusion Technology in Image Analysis of Pretreatment Examination of Patients with Spinal Injury. [PDF]

J Healthc Eng, 2023
Healthcare Engineering JO.
europepmc   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Clinical and Injury-Related Factors Associated with In-Hospital Complications After Traumatic Spinal Injury: A 7-Year Retrospective Cohort Study. [PDF]

J Clin Med
Algarni N, Alrasheed K, Alabdullah O, Almanea A, Alageel M, Alaseem A, Marwan Y, Addar A.   +7 more
europepmc   +1 more source

Spinal injury with spinal ankylosing disorders as a primary cause of death: report of two cases. [PDF]

Int J Emerg Med, 2023
Miyake T, Okada H, Kanda N, Mizuno Y, Suzuki K, Doi T, Yoshida T, Yoshida S, Ogura S.   +8 more
europepmc   +1 more source

Photobiomodulation‑Engineered Extracellular Vesicles Enhance Neural Differentiation via UFL1‑Mediated UFMylation in Spinal Cord Injury

Advanced Science, EarlyView.
Photobiomodulated microglia release engineered extracellular vesicles that deliver UFL1 to the injured spinal cord. UFL1 competitively binds p53 with MDM2, inhibiting p53 ubiquitination and stabilizing p53 signaling. This dual mechanism simultaneously promotes anti‐inflammatory microglial polarization and directs neural stem cell differentiation toward
Yunxiao Fang, Zuomeng Wu, Ruocheng Guo, Cancan Wang, Yue Qin, Yixiang Dong, Aoyun Li, Ao Liu, Chongyu Jia, Tianyu Han, Peiwen Song, Lei Chen, Cailiang Shen   +12 more
wiley   +1 more source