Results 181 to 190 of about 1,373,989 (257)

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

Advanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu, Xue Han, Heng Zhang, Chang Ye, Tianjiao Xia, Xiaoping Gu   +5 more
wiley   +1 more source

American Spinal Injury Association (ASIA) Impairment Scale Motor Grade Outcomes Among Patients With Ballistic Neurologic Injuries Managed Expectantly: A 13-Year Single Institution Retrospective Review and Narrative Review of the Literature. [PDF]

Cureus
Giles TX, Hemphill TR, Derrico NP, Kimball R, Carroll B, Baker KE, Bowen EC, Wilkinson J, Vance GR, Smalley ZS, Washington CW, Marks JJ.   +11 more
europepmc   +1 more source

Effect of Smoking on Motor Recovery After Cervical American Spinal Injury Association Grade D Traumatic Spinal Cord Injury. [PDF]

Int J Spine Surg, 2023
Moon TJ, Furdock R, Blackburn C, Ahn N.
europepmc   +1 more source

Nrsn1–Smarcc1 Coupling Regulates Neural Stem Cell Differentiation and Chronic‐phase Recovery After Ischemic Stroke

Advanced Science, EarlyView.
In the post‐stroke brain, Foxa2 induces the transcriptional upregulation of Nrsn1 in NSCs. Nrsn1 functionally couples with Smarcc1, modulating its nuclear availability and protein abundance, thereby influencing Smarcc1‐associated regulatory programs linked to neuronal lineage commitment. Through this coupling, Nrsn1 promotes the differentiation of NSCs
Ruolin Zhang, Chang Liu, Yuneng Zhou, Kaichen Zhao, Muyang Li, Bingcheng Cai, Ying Wang, Zhiyuan Yuan, Zhaoxin Liu, Zilong Yuan, Yao Xiao, Peiyang Zhou, Ke Shui, Wendai Bao, Min Zhang, Jun Qin, Jun Chen, Xin Yang, Zhiqiang Dong   +18 more
wiley   +1 more source

Neurological Outcomes Following Surgical Resection of Intradural Extramedullary Spinal Tumors: A Retrospective Analysis Using the American Spinal Injury Association (ASIA) Impairment Scale. [PDF]

Cureus
Abboud RS, Sviri GE.
europepmc   +1 more source

Spinal level and cord involvement in the prediction of sepsis development after vertebral fracture repair for traumatic spinal injury. [PDF]

J Neurosurg Spine, 2022
Hoffman SE, Hauser BM, Zaki MM, Gupta S, Chua M, Bernstock JD, Khawaja AM, Smith TR, Zaidi HA.   +8 more
europepmc   +1 more source

Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS‐Initiated Neuroinflammation and BK Channel Suppression

Advanced Science, EarlyView.
Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen, Ying Ma, Lixuan Huang, Xin Chen, Fanliang Kong, Zhenzhou Qian, Mingyue Guan, Xinlin Wang, Yanyan Yang, Shasha Zhang, Peng Li, Renjie Chai   +11 more
wiley   +1 more source

Long term diaphragmatic electrical stimulation: a case report of three cases illustrating the positive aspects and pitfalls in high spinal injury. [PDF]

AME Case Rep
O'Rourke J, Crowe GG, Bluett R, Burke JP, Delaney L, Doherty JG, Hayes M, Mullins G, Robb WB.   +8 more
europepmc   +1 more source

Bone Marrow Macrophage STING Signaling is a Direct Nexus Linking Marrow Adipose Expansion to NAD+ Depletion and Osteogenic Decline in Skeletal Aging

Advanced Science, EarlyView.
This study reveals that during skeletal aging, bone marrow adipocyte‐derived sDPP4 primes STING signaling in macrophages. In combination with mitochondrial DNA, this signaling activates CD38 and depletes local NAD+/NMN, thereby impairing osteogenesis.
Zhichao Li, Kuanhui Gao, Mengjie Wang, Songlin Liang, Dandan Li, Guoqing Tan, Haipeng Xue, Yujie Liu, Peng Zhang, Zhanwang Xu, Wenxiang Cheng, Yongjun Wang, Nianhu Li   +12 more
wiley   +1 more source

What drives clinic follow-up after traumatic spinal injury? An observational cohort study from Tanzania. [PDF]

BMJ Open
Ikwuegbuenyi CA, Woodfield J, Sabas RR, Inzerillo S, Willett N, Cadieux M, Zuckerman SL, Waterkeyn F, Mangat HS, Shabani HK, Härtl R.   +10 more
europepmc   +1 more source