Results 111 to 120 of about 54,218 (214)

Targeting CXCR2 in Nociceptive Sensory Neurons Offers Novel Therapeutic Potentials for Postoperative Pain

Advanced Science, EarlyView.
Tissue incision induces CXCL5 release, which activates neuronal CXCR2 on incision‐innervating sensory neurons. Neuronal CXCR2 couples with TRPA1 to drive mechanical pain and engages p38 MAPK signaling to upregulate TRPV1 and promote heat pain. Targeted Cxcr2 knockdown relieves incisional pain while preserving CXCR2‐dependent neutrophil responses ...
Yushuang Pan, Peiyi Li, Yufeng Chen, Zishan Dong, Yuanyuan Li, Boyu Liu, Yan Tai, Chuan Wang, Jianqiao Fang, Chengyu Yin, Boyi Liu   +10 more
wiley   +1 more source

A Small‐Molecule DEPTAC Rescues Cognitive Deficits by Targeted Dephosphorylation of Pathological Tau

Advanced Science, EarlyView.
TP2 is a fully synthetic small‐molecule dephosphorylation‐targeting chimera that recruits endogenous PP2A‐Bα to Tau, enabling targeted removal of pathological phosphate modifications. In two tauopathy mouse models, systemic TP2 reduces Tau pathology, preserves neuronal and synaptic integrity, improves neuroimmune homeostasis, and rescues cognition ...
Fei Sun, Yang Liu, Qiuzhi Zhou, Qingyuan Hu, Weixia Wang, Yue Xiao, Jingfen Su, Guanting Liu, Miaomiao Sun, Lixia Chen, Hua Li, Ying Yang, Jian‐Zhi Wang   +12 more
wiley   +1 more source

Adverse events among older adults receiving chiropractic spinal manipulation and related treatments: an updated systematic review. [PDF]

Chiropr Man Therap
Daniels CJ, Farabaugh RJ, Salsbury SA, Anderson KR, Kleppe MJ, Whalen WM, Walters SA, Killinger LZ, Schielke AL.   +8 more
europepmc   +1 more source

Smart Flexible Tactile Sensors: Recent Progress in Device Designs, Intelligent Algorithms, and Multidisciplinary Applications

Advanced Intelligent Discovery, EarlyView.
Flexible tactile sensors have considerable potential for broad application in healthcare monitoring, human–machine interfaces, and bioinspired robotics. This review explores recent progress in device design, performance optimization, and intelligent applications. It highlights how AI algorithms enhance environmental adaptability and perception accuracy
Siyuan Wang, Ming Dong, Rongrong Bao, Caofeng Pan   +3 more
wiley   +1 more source

Composition‐Aware Cross‐Sectional Integration for Spatial Transcriptomics

Advanced Intelligent Discovery, EarlyView.
Multi‐section spatial transcriptomics demands coherent cell‐type deconvolution, domain detection, and batch correction, yet existing pipelines treat these tasks separately. FUSION unifies them within a composition‐aware latent framework, modeling reads as cell‐type–specific topics and clustering in embedding space.
Qishi Dong, Zijian Huang, Xuanwu Wang, Zhenghui Feng, Wei Liu, Bingding Huang   +5 more
wiley   +1 more source

The impact of spinal manipulation on lumbar proprioception and its link to pain relief: a randomized controlled trial. [PDF]

Sci Rep
Nyirö L, Dörig M, Suter M, Connolly L, Vogel N, Stadler C, John-Cecere G, Schweinhardt P, Meier ML.   +8 more
europepmc   +1 more source

Are YouTube videos claiming to describe lumbar spinal manipulation techniques adequate? [PDF]

J Man Manip Ther, 2023
Arslan S, Dinç E, Arslan T.
europepmc   +1 more source

Digital Twins for the Design, Interactive Control, and Deployment of Modular, Fiber‐Reinforced Soft Continuum Arms

Advanced Intelligent Systems, EarlyView.
A digital twin framework is presented for modular soft continuum arms built from fiber‐reinforced pneumatic actuators. Cosserat rod models describe individual actuators, while virtual assemblies are formed through serial and parallel networks, preserving actuator‐level architecture and arm deformation.
Seung Hyun Kim, Jiamiao Guo, Arman Tekinalp, Heng‐Sheng Chang, Ugur Akcal, Tixian Wang, Darren Biskup, Benjamin Walt, Girish Chowdhary, Girish Krishnan, Prashant G. Mehta, Mattia Gazzola   +11 more
wiley   +1 more source

AI‐Assisted IoT‐Enabled ECG Monitoring: Integrating Foundational and Generative AI Tools for Sustainable Smart Healthcare—Recent Trends

AI &Innovation, EarlyView.
ABSTRACT The rapid evolution of the Internet of Things (IoT) has significantly advanced the field of electrocardiogram (ECG) monitoring, enabling real‐time, remote, and patient‐centric cardiac care. This paper presents a comprehensive survey of AI assisted IoT‐based ECG monitoring systems, focusing on the integration of emerging technologies such as ...
Amrita Choudhury, Kandarpa Kumar Sarma, Lachit Dutta   +2 more
wiley   +1 more source

Cost-effectiveness of spinal manipulation, exercise, and self-management for spinal pain. [PDF]

Chiropr Man Therap
Leininger BD, Kuntz KM, Hodges JS, Evans R, Enns E, Johnson PJ, Bronfort G.   +6 more
europepmc   +1 more source