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The Journal of Physiology, EarlyView.Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney +4 more
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The Journal of Physiology, EarlyView.Abstract figure legend Metabolic stimulation improves bioenergetics, redox state, hydration and hematologic indices of circulating erythrocytes from sickle cell mice. Retained mitochondria in circulating RBCs from sickle mice are a source of RBC ATP as mitochondria function (ETC, electron transport chain) inhibitors [rotenone, a mitochondrial complex I
Luis E. F. Almeida +4 more
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Intramuscular pathways of maladaptation in overtraining syndrome
The Journal of Physiology, EarlyView.Abstract figure legend The transition from adaptive overreaching to maladaptive overtraining and mechanisms through which excessive training load can lead to performance decline. Four interconnected pathophysiological domains are highlighted: neural fatigue, involving both central and peripheral components such as altered sensory feedback and reflex ...
Emily Shorter +4 more
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Mechanism of action of spinal manipulative therapy
Joint Bone Spine, 2003Spinal manipulative therapy (SMT) acts on the various components of the vertebral motion segment. SMT distracts the facet joints, with faster separation when a cracking sound is heard. Intradiscal pressure may decrease briefly. Forceful stretching of the paraspinal muscles occurs, which induces relaxation via mechanisms that remain to be fully ...
Jean-Yves Maigne
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Forces Exerted During Spinal Manipulative Therapy
Spine, 1993Spinal manipulative therapy has been widely recognized in the medical fields as a conservative treatment modality for spinal dysfunction and pain. Spinal manipulative therapy consists of an application of a thrusting force on a specific part of the spine in a well-defined direction.
W, Herzog +4 more
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Thoracic Epidural Hematoma After Spinal Manipulation Therapy
Journal of Spinal Disorders, 1999Posttraumatic spinal epidural hematoma is an unusual pathology. The authors report the case of a 64-year-old woman who experienced thoracic epidural hematoma during a session of spinal manipulation therapy (SMT). In the literature, such an event has been reported previously only twice.
A. Ruelle, R. Datti, PISANI, ROBERTO
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SPINAL DISPLACEMENT DURING THORACIC SPINAL MANIPULATIVE THERAPY
Journal of Musculoskeletal Research, 2019Background: Vertebrae are linked together with facet and intervertebral joints. The application of a force to a spinal segment therefore impact adjacent areas of the spine. Objective: This study aimed to investigate the posteroanterior (PA) displacement of the thoracocervical spine during the application of thoracic PA mobilization. Methods: Forty-one
Adit Chiradejnant, Sirilak Jungrungsakul
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Spinal manipulative therapy for low-back pain
Cochrane Database of Systematic Reviews, 2004Low-back pain is a costly illness for which spinal manipulative therapy is commonly recommended. Previous systematic reviews and practice guidelines have reached discordant results on the effectiveness of this therapy for low-back pain.To resolve the discrepancies related to the use of spinal manipulative therapy and to update previous estimates of ...
W J J, Assendelft +4 more
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Spinal Manipulative Therapy for Low Back Pain
Journal of the American Academy of Orthopaedic Surgeons, 2003Growing interest in complementary and alternative medicine in the United States has been paralleled by increased use of spinal manipulative therapy in an attempt to manage symptoms of low back pain, spinal stenosis, and spondylolisthesis. Chiropractors have been the main practitioners of spinal manipulative therapy, with osteopaths and physical ...
Rand, Swenson, Scott, Haldeman
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