Towards contrast-agnostic soft segmentation of the spinal cord [PDF]
, 2023 Spinal cord segmentation is clinically relevant and is notably used to compute spinal cord cross-sectional area (CSA) for the diagnosis and monitoring of cord compression or neurodegenerative diseases such as multiple sclerosis. While several semi and automatic methods exist, one key limitation remains: the segmentation depends on the MRI contrast ...
arxiv +1 more source
Automatic Classification of Neuromuscular Diseases in Children Using Photoacoustic Imaging [PDF]
arXiv, 2022 Neuromuscular diseases (NMDs) cause a significant burden for both healthcare systems and society. They can lead to severe progressive muscle weakness, muscle degeneration, contracture, deformity and progressive disability. The NMDs evaluated in this study often manifest in early childhood. As subtypes of disease, e.g.
arxiv
THE BENIGN PROXIMAL SPINAL PROGRESSIVE MUSCULAR ATROPHIES 1
Acta Neurologica Scandinavica, 1968 Investigations by W o h l f a r t , F e z & Eliasson (1955), and by Kugelberg & Welander ( 1956) established proximal spinal progressive muscular atrophy as a distinct entity. The group of proximal spinal muscular atrophies (henceforth referred to as the
H. Peters +3 more
semanticscholar +1 more source
Families' Perceptions of Powered Mobility for Participation in Children With Spinal Muscular Atrophy Type 1: A Photovoice Study. [PDF]
Health ExpectABSTRACT Background and Purpose Spinal muscular atrophy type 1 (SMA1) is a neuromuscular disorder that severely limits movement and autonomy in young children. Early powered mobility has proved to be a valuable intervention to promote participation, social engagement and emotional well‐being.
Coello-Villalón M +7 more
europepmc +2 more sources
Shape Analysis for Pediatric Upper Body Motor Function Assessment [PDF]
arXiv, 2022 Neuromuscular disorders, such as Spinal Muscular Atrophy (SMA) and Duchenne Muscular Dystrophy (DMD), cause progressive muscular degeneration and loss of motor function for 1 in 6,000 children. Traditional upper limb motor function assessments do not quantitatively measure patient-performed motions, which makes it difficult to track progress for ...
arxiv
Clinico-epidemiologic characteristics of spinal muscular atrophy among Egyptians [PDF]
, 2011 Spinal muscular atrophy (SMA) is characterized by progressive hypotonia and muscular weakness because of progressive degeneration of alpha motor neuron from anterior horn cells in the spinal cord. It is inherited by an autosomal recessive pattern.
El-Sayed, NS, Shawky, RM
core +2 more sources
Анализ социально-экономического бремени спинальной мышечной атрофии в Российской Федерации [PDF]
, 2021 Introduction. Spinal muscular atrophies (SMA) are clinically and genetically heterogeneous congenital orphan diseases that lead to progressive spinal motoneurons degeneration and loss of their function. There are 4 types of SMA with type I being the most
A. A. Kurylev +15 more
core +2 more sources
A Causal Inference Framework for Leveraging External Controls in Hybrid Trials [PDF]
arXiv, 2023 We consider the challenges associated with causal inference in settings where data from a randomized trial is augmented with control data from an external source to improve efficiency in estimating the average treatment effect (ATE). Through the development of a formal causal inference framework, we outline sufficient causal assumptions about the ...
arxiv
Investigating a domain adaptation approach for integrating different measurement instruments in a longitudinal clinical registry [PDF]
arXiv, 2023 In a longitudinal clinical registry, different measurement instruments might have been used for assessing individuals at different time points. To combine them, we investigate deep learning techniques for obtaining a joint latent representation, to which the items of different measurement instruments are mapped.
arxiv
Noninvasive optical estimation of CSF thickness for brain-atrophy monitoring [PDF]
Biomedical Optics Express 9 (2018) 4094-4112, 2018 Dementia disorders are increasingly becoming sources of a broad range of problems, strongly interfering with normal daily tasks of a growing number of individuals. Such neurodegenerative diseases are often accompanied with progressive brain atrophy that, at late stages, leads to drastically reduced brain dimensions.
arxiv +1 more source