Results 151 to 160 of about 605,611 (288)

Glymphatic Dysfunction in Children With Type 2 and 3 Spinal Muscular Atrophy. [PDF]

CNS Neurosci Ther
Lan S, Xiang P, Yan C, Nie H, Wang H, Xu B, Yang Z, Tang W, Li Y, Liang Y, Chen Y.   +10 more
europepmc   +1 more source

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

Abnormal auditory neural activity in individuals with spinal muscular atrophy. [PDF]

Brain Commun
Rance G, Yiu EM.
europepmc   +1 more source

Dexmedetomidine infusions improve cardiovascular and renal function in anaesthetised, experimentally endotoxaemic horses

Equine Veterinary Journal, EarlyView.
Abstract Background Dexmedetomidine infusions are beneficial in anaesthetised endotoxaemic horses when administered concurrent to endotoxin, but post‐conditioning effects are unknown. Objectives To evaluate whether a dexmedetomidine infusion is beneficial in horses administered Escherichia coli O55:B5 lipopolysaccharides (LPS) endotoxin prior to ...
Sera Lee, Rachel C. Hector, Lynn Pezzanite, Eric Gilleland, Marlis L. Rezende   +4 more
wiley   +1 more source

Access to care for adults living with spinal muscular atrophy in the UK. [PDF]

BMJ Neurol Open
Muni-Lofra R, Borland H, Nevin K, Rutherford A, Dungavel A, Michell-Sodhi J, Chatfield S, Pape K, Rose A, Fenty P, Martin G, Narayan S, Bartram E, Emery N, Marco MD, Manchester E, White N, Tomos H, Davies E, Morris F, Carver A, Karkkainen E, Page J, Norwood F, Davis H, Walters RJ, Dougan CF, Shanmugarajah PD, Farrugia ME, Willis TA, Brady S, Kiss-Csenki A, Merrison A, Sedehizadeh S, Brierley C, Davies NP, Galtrey CM, Parton M, Lilleker JB, Hewamadduma C, Bettolo CM.   +40 more
europepmc   +1 more source

Similar locomotor patterns across Quarter Horse disciplines inform lameness assessment

Equine Veterinary Journal, EarlyView.
Abstract Background Lineage‐based selection is central to the Quarter Horse industry and is often justified by the assumption that morphology determines locomotor function. However, objective evidence linking static conformation to discipline‐specific locomotor behaviour under standardised conditions remains limited.
Renata Farinelli de Siqueira, Lavínia Andressa Brito, Isabela Marques de Figueiredo, Ana Clara Rocha dos Santos, Larissa Santos dos Anjos   +4 more
wiley   +1 more source

Cognitive and neurodevelopmental outcomes in spinal muscular atrophy: a scoping review. [PDF]

Front Cell Neurosci
Gnazzo M, Pisanò G, Baldini V, Giordani S, Caiazza L, Piccolo B, Turco E, Esposito S, Pera MC.   +8 more
europepmc   +1 more source

Engineering mRNA‐LNP Medicines for the Ageing Brain: Opportunities and Challenges for Neurodegenerative Diseases

Exploration, EarlyView.
This review highlights recent advances in engineering messenger RNA (mRNA)‐lipid nanoparticles (LNPs) to cross the ageing blood–brain barrier and target neurodegenerative diseases. It outlines design principles, delivery routes, and translational challenges, charting a roadmap towards clinical application of mRNA‐LNP therapeutics for neurodegenerative ...
Abdel Ali Belaidi, Denzil L. Furtado, Francesca Alves, Rebecca M. Nisbet, Scott Ayton, Ashley I. Bush   +5 more
wiley   +1 more source

Spinal muscular atrophy in the disease-modifying therapy era: successes, limitations and future directions. [PDF]

Front Mol Med
Sexton MM, Crow EW, Peng CA.
europepmc   +1 more source

Wearable Robot Boosts Muscle Recovery in Adolescents With Spinal Muscular Atrophy

FlexTech, EarlyView.
Isokinetic training robot with a variable stiffness mechanism for juveniles with SMA type II. Credit: Yuebing Li et al./Nature. ABSTRACT Yuebing Li and colleagues developed a lightweight wearable device integrating a variable‐stiffness mechanism with a back‐drivable damping motor to deliver isokinetic resistance training for adolescents with spinal ...
Yin Huang
wiley   +1 more source