Results 271 to 280 of about 120,291 (395)

Modeling the phenotype of spinal muscular atrophy by the direct conversion of human fibroblasts to motor neurons

, 2017
Qi‐Jie Zhang, Jin-Jing Li, Xiang Lin, Ying‐Qian Lu, Xinxin Guo, En‐Lin Dong, Miao Zhao, J. He, Ning Wang, Wan‐Jin Chen   +9 more
openalex   +2 more sources

Physiologically‐Based Pharmacokinetic Modeling to Support Pediatric Clinical Development: An IQ Working Group Perspective on the Current Status and Challenges

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Pediatric extrapolation strategies issued by health authorities have streamlined pediatric drug development and reduced the unnecessary burden of conducting pediatric clinical studies. In line with these strategies, physiologically based pharmacokinetic (PBPK) models have been utilized extensively for initial dosing regimen and sampling ...
James W. T. Yates, Michael Zientek, Kunal S. Taskar, Wen Lin, Tycho Heimbach, Stefan Willmann, Jessica Rehmel, Neil Parrott, Michael Hanley, Justine Badee, Yuan Chen, Susan Cole, Loeckie De Zwart, Sebastian Haertter, Rongrong Jiang, Masakatsu Kotsuma, Guiqing Liang, Yu‐Wei Lin, Jing Liu, Ying Ou, Juliane Rascher, Naveed A. Shaik, Jan Wahlstrom, Xiaofeng Wang, Guangqing Xiao, Ka Lai Yee, S. Y. Amy Cheung   +26 more
wiley   +1 more source

The lumbar multifidus : from anatomy to rehabilitation [PDF]

, 2010
Cagnie, Barbara, Danneels, Lieven, Dickx, Nele   +2 more
core   +1 more source

Micropatterned Surfaces with Unidirectional Wetting Properties for Liquid Transport

Small Structures, EarlyView.
Micropatterned surfaces that guide droplets in a single direction are gaining attention for their role in liquid transport. This review explores how surface designs enable such behavior, from gravity‐driven flow to stimulus‐responsive movement. It also discusses fabrication techniques, design challenges, and emerging strategies to advance directional ...
Elham Lori Zoudani, Prabuddha De Saram, Stefanie Feih, Hoang Huy Vu, Nam‐Trung Nguyen, Navid Kashaninejad   +5 more
wiley   +1 more source

Effects of physical therapy on motor ability in patients with spinal muscular atrophy III: a study protocol for a randomised controlled trial. [PDF]

BMJ Open
Zhang J, Wang B, He J, Zhu L, Dong X.
europepmc   +1 more source

Clinical Characteristics of Cases with Spinal Muscular Atrophy

, 2016
Mehmet Canpolat, Ayşe Kaçar Bayram, Oğuzhan Bahadir, Hüseyin Per, Hakan Gümüş, Munis Dündar, Sefer Kumandaş   +6 more
openalex   +1 more source

Screening for spinal muscular atrophy

Medical Journal of Australia, 2018
Sampaio, H, Wilcken, B, Farrar, M
openaire   +3 more sources

Review of published research on primary dysautonomia of domestic animals

Veterinary Record, EarlyView.
Abstract An article published in 1992 by Marion M. Pollin and I.R. Griffiths reviewed the topic of primary dysautonomias of the autonomic nervous system of unidentified origin in multiple domestic species, specifically cats, dogs and horses. Thirty‐one years later, we appear no closer to identifying the causal agents of these strikingly similar ...
Tanith Harte, David Smith, Jo Moore, Beth Wells   +3 more
wiley   +1 more source

Drug Candidate BIO101 for Spinal Muscular Atrophy as Monotherapy or Combined With the Antisense Oligonucleotide ASO-10-27. [PDF]

J Cachexia Sarcopenia Muscle
Bézier C, Cottin S, Hashemi PN, El Khoury M, Clerc Z, Balducci C, Sapaly D, Weill L, Lafont R, Veillet S, Dilda PJ, Charbonnier F, Latil M, Biondi O.   +13 more
europepmc   +1 more source

AAV-based approaches to model and treat spinal muscular atrophy

, 2012
Adam K. Bevan
openalex   +1 more source