Results 221 to 230 of about 925,666 (291)

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Filum terminale schwannoma with new onset of severe low back pain and radiculopathy: illustrative case. [PDF]

J Neurosurg Case Lessons
Passman JN, Stack EH, Kleyner RS, Servider J, Bellow E, Seidman R, Mushlin H.   +6 more
europepmc   +1 more source

Novel planning pipeline utilizing the Surgical Theater system for pediatric epilepsy surgery

Epilepsia Open, EarlyView.
Abstract Objective Advances in the analysis and collation of radiographic datasets have enhanced presurgical planning for various neurosurgical procedures, including clipping of cerebral aneurysms, surgical resection of tumors, and arteriovenous malformation management.
Lisa B. E. Shields, Hunain Abri, Cemal Karakas, Shannon D. Davis, Ian S. Mutchnick   +4 more
wiley   +1 more source

Thoracic Spinal Sclerosing Epithelioid Fibrosarcoma Mimicking Schwannoma: Case Report and Literature Review. [PDF]

Curr Oncol
Creatura D, El Choueiri J, Benato A, Anselmi L, Baram A, De Robertis M, Brembilla C, Pessina F, Fornari M, Capo G.   +9 more
europepmc   +1 more source

Multimodal approach to characterize surgically removed epileptogenic zone from patients with focal drug‐resistant epilepsy: From operating room to wet lab

Epilepsia Open, EarlyView.
Abstract Objective We have established a comprehensive sample handling protocol designed for the multiscale assessment of epileptogenic tissue. This protocol aims to identify novel therapeutic targets and enhance the diagnosis and stratification of patients with drug‐resistant epilepsy, thereby optimizing their treatment with anti‐seizure medications ...
Jenni Kyyriäinen, Adriana Della Pietra, Mastaneh Torkamani‐Azar, Mireia Gómez‐Budia, Polina Abushik, Nataliia Novosolova, Henri Eronen, Omar Narvaez, Ekaterina Paasonen, Vera Lezhneva, Anssi Pelkonen, Liudmila Saveleva, Antti Huotarinen, Ilya Belevich, Eija Jokitalo, Kuopio Epilepsy Center Epilepsy Surgery Group, Leena Jutila, Tuomas Rauramaa, Arto Immonen, Ville Leinonen, Jussi Tohka, Olli Gröhn, Reetta Kälviäinen, Tarja Malm, Alejandra Sierra   +24 more
wiley   +1 more source

Benign or aggressive? Understanding spinal melanocytomas in comparison to malignant melanoma. [PDF]

J Neurooncol
Ryba A, Mohme T, Kerschbaumer J, von Bronewski E, Hubertus V, Butenschoen VM, Kramer A, Stengel FC, Stienen MN, Battistelli M, Polli FM, Meyer HS, Dührsen L, Mende KC, Westphal M, Ringel F, Meyer B, Onken J, Thome C, Eicker SO, Mohme M.   +20 more
europepmc   +1 more source

Insect‐Derived Bioactives for Glycemic Control and Gut Health: A Review

Food Frontiers, EarlyView.
Insect‐derived bioactive compounds (e.g., peptides, polysaccharides) effectively regulate blood glucose through dual mechanisms: directly inhibiting carbohydrate‐digesting enzymes and glucose transporters, and indirectly modulating gut microbiota to enhance intestinal barrier integrity.
Chaoyi Lv, Yuanyuan Huang, Mokhtar Dabbour, Benjamin Kumah Mintah, Ronghai He, Haile Ma   +5 more
wiley   +1 more source

Diagnostic challenges of spinal gout: patient series. [PDF]

J Neurosurg Case Lessons
Zhou Y, Wu H, Huang Y, Man Y, He M.
europepmc   +1 more source

From Genomic Fossils to Functional Elements: The Evolving Story of Pseudogenes

Advanced Genetics, EarlyView.
This review begins with an introduction, summarizing the research background in pseudogene studies. It then contains three aspects: identification of pseudogenes, detailing their classification and features in metazoan genomes; functional pseudogenes, introducing their reactivation and regulation mechanisms; and pseudogenes’ contribution to species ...
Mengyao Sun, Yanni Ma, Jia Yu
wiley   +1 more source

Unmasking benign intradural-extramedullary spinal tumors: a systematic review on treatment outcomes and radiological features. [PDF]

Ann Med Surg (Lond)
Czyżewski W, Szymoniuk M, Litak J, Sobstyl J, Kus-Budzynska K, Buchalska B, Chaurasia B, Mandat T, Torres K, Staśkiewicz G.   +9 more
europepmc   +1 more source