Results 281 to 290 of about 1,760,803 (361)

The Dynamics of Neurofilament Light Chain in Spinal Muscular Atrophy

Annals of Neurology, EarlyView.
Objective Newborn screening (NBS) for spinal muscular atrophy (SMA) facilitates early diagnosis and treatment for affected individuals. However, fluid biomarkers that provide early insights into disease activity and outcomes in a neonatal cohort and those unable to access (due to reimbursement criteria) or deferring immediate treatment are lacking ...
Arlene D'Silva, Karen Herbert, Lakshmi Balaji, Jia Mei He, Tejaswi Kandula, Hugo A. Sampaio, Hooi‐Ling Teoh, Esther Tantsis, Jihee Sohn, Nancy Briggs, Nickson Ning, Matthew C. Kiernan, Didu S. Kariyawasam, Michelle A. Farrar   +13 more
wiley   +1 more source

A Novel Acetylcholine Nanosensor for Single Vesicle Storage and Sub‐Quantal Exocytosis in Living Neurons and Organoids

Angewandte Chemie, EarlyView.
Schematic representation of M@E@CF nanosensors for detecting vesicular storage and release in cholinergic neurons and brain organoids. (A) Nano‐tip microelectrodes modification via molds fabricated through 3D printing. (B) the reaction mechanism for acetylcholine detection at the electrode interface.
Wanying Zhu, Yufan Zhang, Hanwen Yu, Da Wang, Xinyue Zhang, Xiaowen Du, Shanshan Wu, Bingzhi Li, Yizhou Zhang, Hongliang Xin, Xing Guo, Yan Liu   +11 more
wiley   +1 more source

Targeted transcriptional upregulation of SENP1 by CRISPR activation enhances deSUMOylation pathways to elicit antinociception in the spinal nerve ligation model of neuropathic pain. [PDF]

Pain
Gomez K, Allen HN, Duran P, Loya-Lopez S, Calderon-Rivera A, Moutal A, Tang C, Nelson TS, Perez-Miller S, Khanna R.   +9 more
europepmc   +1 more source

Accurate diagnosis and treatment of sacral meningeal cysts without spinal nerve root fibres: identifying leakage orificium using high-resolution spherical arbitrary-dimensional reconstructing magnetic resonance imaging. [PDF]

Front Neurol
Yang C, Lou X, Huang L, Ma Q, Yin X, Zhao Q, Wu C, Wu H, Sun J.   +8 more
europepmc   +1 more source

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Spinal Nerve Root Stimulation

Progress in neurological surgery, 2011
Spinal nerve root stimulation (SNRS) is a neuromodulation technique that is used to treat chronic pain. This modality places stimulator electrode array(s) along the spinal nerve roots, creating stimulation paresthesias within the distribution of the target nerve root(s), thereby treating pain in that same distribution. There are several different forms
Christopher P, Kellner, Michael A, Kellner, Christopher J, Winfree   +2 more
openaire   +3 more sources

P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury

Nature, 2003
M. Tsuda, Yukari Shigemoto-Mogami, S. Koizumi, Akito Mizokoshi, S. Kohsaka, M. Salter, Kazuhide Inoue   +6 more
semanticscholar   +3 more sources

A Review of the History, Anatomy, and Development of the C1 Spinal Nerve.

World Neurosurgery, 2019
The C1 spinal nerve is a fascinating anatomical structure owing to its wide range of variations. Throughout history, understanding of the cranial and spinal nerves has probably influenced the current view among anatomists about this particular nerve ...
Santiago Gutierrez, T. Huynh, J. Iwanaga, A. Dumont, C. Bui, R. Tubbs   +5 more
semanticscholar   +1 more source

A spinal microglia population involved in remitting and relapsing neuropathic pain

Science, 2022
Neuropathic pain is often caused by injury and diseases that affect the somatosensory system. Although pain development has been well studied, pain recovery mechanisms remain largely unknown.
Keita Kohno, Ryoji Shirasaka, Kohei Yoshihara, Satsuki Mikuriya, Kaori Tanaka, K. Takanami, Kazuhide Inoue, H. Sakamoto, Y. Ohkawa, Takahiro Masuda, M. Tsuda   +10 more
semanticscholar   +1 more source

Spinal Accessory Nerve Injury

Clinical Orthopaedics and Related Research, 1999
Injury to the spinal accessory nerve can lead to dysfunction of the trapezius. The trapezius is a major scapular stabilizer and is composed of three functional components. It contributes to scapulothoracic rhythm by elevating, rotating, and retracting the scapula.
J M, Wiater, L U, Bigliani
openaire   +2 more sources

Spinal Nerve Root Compression

Spine, 1995
The pathophysiology of sciatica is not completely understood, although our understanding of its causes is increasing. Mechanical alterations combined with inflammatory changes lead to pain. Compression alters nerve root conduction and compromises the nutritional support of spinal nerve roots (through intrinsic and extrinsic vascularity and cerebral ...
S R, Garfin, B, Rydevik, B, Lind, J, Massie   +3 more
openaire   +2 more sources