Results 41 to 50 of about 74,410 (312)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Diffusion tensor imaging reveals changes in microstructural integrity along compressed nerve roots that correlate with chronic pain symptoms and motor deficiencies in elderly stenosis patients

NeuroImage: Clinical, 2019
Age-related degenerative changes in the lumbar spine frequently result in nerve root compression causing severe pain and disability. Given the increasing incidence of lumbar spinal disorders in the aging population and the discrepancies between the use ...
S.W. Hughes, P.J. Hellyer, D.J. Sharp, R.D. Newbould, M.C. Patel, P.H. Strutton   +5 more
doaj   +1 more source

A rare intraoperative spinal cord injury caused by thoracic 8 nerve root interruption during posterior vertebral column resection surgery for severe congenital kyphoscoliosis: a case report

BMC Neurology, 2020
Background To our knowledge, the exposed nerve roots in thoracic spine are usually sacrificed to facilitate osteotomy during posterior vertebral column resection (PVCR) for severe spinal deformity.
Shujie Wang, Zhifu Ren, Zhen Yang, Jianguo Zhang   +3 more
doaj   +1 more source

An Anatomical Variation in the Formation of the Inferior Root of Ansa Cervicalis [PDF]

Journal of Clinical and Diagnostic Research, 2013
During regular dissections, we observed an unusual organization of the inferior root of Ansa Cervicalis (AC). The superior root of ansa arose normally from the hypoglossal nerve. The ventral ramus of the C2 spinal nerve divided into two branches. One of
Srinivasa Rao Sirasanagandla, Satheesha Nayak B, Naveen Kumar, Jyothsna Patil, Swamy Ravindra S   +4 more
doaj   +1 more source

MRI neurography and diffusion tensor imaging of a sciatic perineuroma in a child [PDF]

, 2018
Perineuroma, rare in children, presents as a painless mononeuropathy of a major nerve trunk. Resection of the lesion with end-to-end sural nerve grafting appears to be the treatment of choice. This technique is not recommended if the unhealthy segment of
De Coulon, Geraldo, Lobrinus, Johannes, Merlini, Laura, Vargas, Maria, Viallon, Magalie   +4 more
core  

Abnormal motoneuron migration, differentiation, and axon outgrowth in spinal muscular atrophy [PDF]

, 2008
The role of heterotopic (migratory) motoneurons (HMN) in the pathogenesis of spinal muscular atrophy (SMA) is still controversial. We examined the occurrence and amount of HMN in spinal cord tissue from eight children with SMA (six with SMA-I and two ...
Barišić, Nina, Hof, Patrick R., Islam, Atiqul, Jovanov Milošević, Nataša, Krušlin, Božo, Lucassen, Paul J., Mladinov, Mihovil, Pajtak, Alen, Sertić, Jadranka, Šešo Šimić, Đurđica, Šimić, Goran   +10 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Differentiation between Anterior and Posterior Roots Using Compound Muscle Action Potential in Intradural Extramedullary Spinal Tumor Surgery

Neurologia Medico-Chirurgica
This study aims to determine the cutoff values for the compound muscle action potential (CMAP) stimulus in anatomically identified anterior (motor nerve) and posterior roots (sensory nerve) during cervical intradural extramedullary tumor surgery.
Naoyuki HARADA, Yuki SAKAEYAMA, Yutaka FUCHINOUE, Mitsuyoshi ABE, Sayaka TERAZONO, Chie MATSUURA, Shuhei KUBOTA, Masataka MIKAI, Nobuo SUGO, Kunio SUGIYAMA, Kosuke KONDO, Masaaki NEMOTO   +11 more
doaj   +1 more source

Theory of Bowstring Disease: Diagnosis and Treatment Bowstring Disease

Orthopaedic Surgery, 2019
Bowstring disease (BSD) is a new classification of spine disease caused by axial stretched lesion on nerve roots and the spinal cord, which is differentiated from disc herniation and canal stenosis in that it is caused by nerve compression lesions.
Jian‐gang Shi, Xi‐ming Xu, Jing‐chuan Sun, Yuan Wang, Qing‐jie Kong, Guo‐dong Shi   +5 more
doaj   +1 more source